COMPARISON OF OVULATION INDUCTION LETROZOLE AND CLOMIPHENE CITRATE IN SUBFERTILE WOMEN WITH POLYCYSTIC OVARIAN SYNDROME

Objective: To compare the ovulation induction of letrozole and clomiphene citrate in sub-fertile women with polycystic ovarian syndrome. Study Design: Quasi experimental study. Place and Duration of Study: Combined Military Hospital Rawalpindi, from Jun 2018 to Aug 2019. Methodology: A tota...

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Autores principales:	Amna Shafiq, Rabiya Akbar, Uzma Urooj, Sadaf Zohra, Shazia Afzal, Madiha Tanveer
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2021
Materias:	clomiphene citrate letrozole polycystic ovarian syndrome Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/ad0a9e59ac614a33baed4d317d25f6cd
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spelling	oai:doaj.org-article:ad0a9e59ac614a33baed4d317d25f6cd2021-11-24T04:23:08ZCOMPARISON OF OVULATION INDUCTION LETROZOLE AND CLOMIPHENE CITRATE IN SUBFERTILE WOMEN WITH POLYCYSTIC OVARIAN SYNDROME0030-96482411-8842https://doaj.org/article/ad0a9e59ac614a33baed4d317d25f6cd2021-10-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/6554/3634https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To compare the ovulation induction of letrozole and clomiphene citrate in sub-fertile women with polycystic ovarian syndrome. Study Design: Quasi experimental study. Place and Duration of Study: Combined Military Hospital Rawalpindi, from Jun 2018 to Aug 2019. Methodology: A total of 116 married sub-fertile women with polycystic ovarian syndrome, 16-40 years of age were included. Patients with previous surgery related to genital tract, hypothyroidism and chronic renal failure were excluded. Letrozole 5.0mg daily from Day 5-9 of menstruation was prescribed to group A women and clomiphene citrate 100 mg daily from Day 5-9 of menses was given to group B women. Results: In group A and in group B, mean age was 29.78 ± 4.71 years and 29.95 ± 4.22 years respectively. Most of the patients 59 (50.86%) were between 18-30 years of age. Mean duration since marriage was 4.23 ± 1.42 years. Mean body mass index was 29.71 ± 2.65 kg/m2. Frequency of ovulation of clomiphene citrate and letrozole in sub-fertile women with polycystic ovaries was 28 (42.28%) versus 42 (72.41%) respectively (p-value=0.008). Conclusion: This study concluded that ovulation induction of letrozole is better than clomiphene citrate in sub-fertile women with polycystic ovarian syndrome.Amna ShafiqRabiya AkbarUzma UroojSadaf ZohraShazia AfzalMadiha TanveerArmy Medical College Rawalpindiarticleclomiphene citrateletrozolepolycystic ovarian syndromeMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 71, Iss 5, Pp 1844-1847 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	clomiphene citrate letrozole polycystic ovarian syndrome Medicine R Medicine (General) R5-920
spellingShingle	clomiphene citrate letrozole polycystic ovarian syndrome Medicine R Medicine (General) R5-920 Amna Shafiq Rabiya Akbar Uzma Urooj Sadaf Zohra Shazia Afzal Madiha Tanveer COMPARISON OF OVULATION INDUCTION LETROZOLE AND CLOMIPHENE CITRATE IN SUBFERTILE WOMEN WITH POLYCYSTIC OVARIAN SYNDROME
description	Objective: To compare the ovulation induction of letrozole and clomiphene citrate in sub-fertile women with polycystic ovarian syndrome. Study Design: Quasi experimental study. Place and Duration of Study: Combined Military Hospital Rawalpindi, from Jun 2018 to Aug 2019. Methodology: A total of 116 married sub-fertile women with polycystic ovarian syndrome, 16-40 years of age were included. Patients with previous surgery related to genital tract, hypothyroidism and chronic renal failure were excluded. Letrozole 5.0mg daily from Day 5-9 of menstruation was prescribed to group A women and clomiphene citrate 100 mg daily from Day 5-9 of menses was given to group B women. Results: In group A and in group B, mean age was 29.78 ± 4.71 years and 29.95 ± 4.22 years respectively. Most of the patients 59 (50.86%) were between 18-30 years of age. Mean duration since marriage was 4.23 ± 1.42 years. Mean body mass index was 29.71 ± 2.65 kg/m2. Frequency of ovulation of clomiphene citrate and letrozole in sub-fertile women with polycystic ovaries was 28 (42.28%) versus 42 (72.41%) respectively (p-value=0.008). Conclusion: This study concluded that ovulation induction of letrozole is better than clomiphene citrate in sub-fertile women with polycystic ovarian syndrome.
format	article
author	Amna Shafiq Rabiya Akbar Uzma Urooj Sadaf Zohra Shazia Afzal Madiha Tanveer
author_facet	Amna Shafiq Rabiya Akbar Uzma Urooj Sadaf Zohra Shazia Afzal Madiha Tanveer
author_sort	Amna Shafiq
title	COMPARISON OF OVULATION INDUCTION LETROZOLE AND CLOMIPHENE CITRATE IN SUBFERTILE WOMEN WITH POLYCYSTIC OVARIAN SYNDROME
title_short	COMPARISON OF OVULATION INDUCTION LETROZOLE AND CLOMIPHENE CITRATE IN SUBFERTILE WOMEN WITH POLYCYSTIC OVARIAN SYNDROME
title_full	COMPARISON OF OVULATION INDUCTION LETROZOLE AND CLOMIPHENE CITRATE IN SUBFERTILE WOMEN WITH POLYCYSTIC OVARIAN SYNDROME
title_fullStr	COMPARISON OF OVULATION INDUCTION LETROZOLE AND CLOMIPHENE CITRATE IN SUBFERTILE WOMEN WITH POLYCYSTIC OVARIAN SYNDROME
title_full_unstemmed	COMPARISON OF OVULATION INDUCTION LETROZOLE AND CLOMIPHENE CITRATE IN SUBFERTILE WOMEN WITH POLYCYSTIC OVARIAN SYNDROME
title_sort	comparison of ovulation induction letrozole and clomiphene citrate in subfertile women with polycystic ovarian syndrome
publisher	Army Medical College Rawalpindi
publishDate	2021
url	https://doaj.org/article/ad0a9e59ac614a33baed4d317d25f6cd
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COMPARISON OF OVULATION INDUCTION LETROZOLE AND CLOMIPHENE CITRATE IN SUBFERTILE WOMEN WITH POLYCYSTIC OVARIAN SYNDROME

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