IN VITRO EFFECT OF TERPENOIDS - RICH EXTRACT OF Momordica charantia ON ALPHA GLUCOSIDASE ACTIVITY

ABSTRACT Background: Momordica charantia is a vine, native to tropics and subtropics that has found use in herbal medicine. In Nigeria, the plant is locally used in the treatment of diabetes. Objective: To investigate the inhibitory effect of terpenoid-rich extract from Momordica charantia on α-g...

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Autores principales:	A. B. SALLAU, R. N. YAKUBU, S. M. ABDULLAHI, A. SALIHU, B. Y. BONIFACE
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia
Materias:	α-glucosidase terpenoids inhibitor inhibition hyperglycemia extract Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/ad0b890c8b2642dd9000234e45461f73
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spelling	oai:doaj.org-article:ad0b890c8b2642dd9000234e45461f732021-12-02T09:57:43ZIN VITRO EFFECT OF TERPENOIDS - RICH EXTRACT OF Momordica charantia ON ALPHA GLUCOSIDASE ACTIVITY0121-400410.17533/udea.vitae.v25n3a05https://doaj.org/article/ad0b890c8b2642dd9000234e45461f73http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0121-40042018000300148&lng=en&tlng=enhttps://doaj.org/toc/0121-4004ABSTRACT Background: Momordica charantia is a vine, native to tropics and subtropics that has found use in herbal medicine. In Nigeria, the plant is locally used in the treatment of diabetes. Objective: To investigate the inhibitory effect of terpenoid-rich extract from Momordica charantia on α-glucosidase activity. Method: The inhibitory effect of the terpenoid-rich extract from Momordica charantia on the activity of alpha-glucosidase from Saccharomyces cerevisiae as well as the determination of the mode of inhibition were investigated using in vitro assay methods. Results: The results revealed that the terpenoid-rich extract had a high IC50 of 1.60 mg/mL. The Lineweaver-Burk plot revealed that the extract exhibited partially mixed-type inhibition of α-glucosidase. Conclusions: It can be inferred from this study that although terpenoid-rich extract inhibited α-glucosidase, further purification will be necessary on the extract so as to increase its potency as an inhibitor of α-glucosidase. The action of the extract on α-glucosidase provided an insight into the probable mechanism of action of Momordica charantia in reducing hyperglycemia.A. B. SALLAUR. N. YAKUBUS. M. ABDULLAHIA. SALIHUB. Y. BONIFACEUniversidad de Antioquiaarticleα-glucosidaseterpenoidsinhibitorinhibitionhyperglycemiaextractFood processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 25, Iss 3, Pp 148-153
institution	DOAJ
collection	DOAJ
language	EN
topic	α-glucosidase terpenoids inhibitor inhibition hyperglycemia extract Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
spellingShingle	α-glucosidase terpenoids inhibitor inhibition hyperglycemia extract Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 A. B. SALLAU R. N. YAKUBU S. M. ABDULLAHI A. SALIHU B. Y. BONIFACE IN VITRO EFFECT OF TERPENOIDS - RICH EXTRACT OF Momordica charantia ON ALPHA GLUCOSIDASE ACTIVITY
description	ABSTRACT Background: Momordica charantia is a vine, native to tropics and subtropics that has found use in herbal medicine. In Nigeria, the plant is locally used in the treatment of diabetes. Objective: To investigate the inhibitory effect of terpenoid-rich extract from Momordica charantia on α-glucosidase activity. Method: The inhibitory effect of the terpenoid-rich extract from Momordica charantia on the activity of alpha-glucosidase from Saccharomyces cerevisiae as well as the determination of the mode of inhibition were investigated using in vitro assay methods. Results: The results revealed that the terpenoid-rich extract had a high IC50 of 1.60 mg/mL. The Lineweaver-Burk plot revealed that the extract exhibited partially mixed-type inhibition of α-glucosidase. Conclusions: It can be inferred from this study that although terpenoid-rich extract inhibited α-glucosidase, further purification will be necessary on the extract so as to increase its potency as an inhibitor of α-glucosidase. The action of the extract on α-glucosidase provided an insight into the probable mechanism of action of Momordica charantia in reducing hyperglycemia.
format	article
author	A. B. SALLAU R. N. YAKUBU S. M. ABDULLAHI A. SALIHU B. Y. BONIFACE
author_facet	A. B. SALLAU R. N. YAKUBU S. M. ABDULLAHI A. SALIHU B. Y. BONIFACE
author_sort	A. B. SALLAU
title	IN VITRO EFFECT OF TERPENOIDS - RICH EXTRACT OF Momordica charantia ON ALPHA GLUCOSIDASE ACTIVITY
title_short	IN VITRO EFFECT OF TERPENOIDS - RICH EXTRACT OF Momordica charantia ON ALPHA GLUCOSIDASE ACTIVITY
title_full	IN VITRO EFFECT OF TERPENOIDS - RICH EXTRACT OF Momordica charantia ON ALPHA GLUCOSIDASE ACTIVITY
title_fullStr	IN VITRO EFFECT OF TERPENOIDS - RICH EXTRACT OF Momordica charantia ON ALPHA GLUCOSIDASE ACTIVITY
title_full_unstemmed	IN VITRO EFFECT OF TERPENOIDS - RICH EXTRACT OF Momordica charantia ON ALPHA GLUCOSIDASE ACTIVITY
title_sort	in vitro effect of terpenoids - rich extract of momordica charantia on alpha glucosidase activity
publisher	Universidad de Antioquia
url	https://doaj.org/article/ad0b890c8b2642dd9000234e45461f73
work_keys_str_mv	AT absallau invitroeffectofterpenoidsrichextractofmomordicacharantiaonalphaglucosidaseactivity AT rnyakubu invitroeffectofterpenoidsrichextractofmomordicacharantiaonalphaglucosidaseactivity AT smabdullahi invitroeffectofterpenoidsrichextractofmomordicacharantiaonalphaglucosidaseactivity AT asalihu invitroeffectofterpenoidsrichextractofmomordicacharantiaonalphaglucosidaseactivity AT byboniface invitroeffectofterpenoidsrichextractofmomordicacharantiaonalphaglucosidaseactivity
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IN VITRO EFFECT OF TERPENOIDS - RICH EXTRACT OF Momordica charantia ON ALPHA GLUCOSIDASE ACTIVITY

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