Clinical and imaging features of surgically treated low lumbar osteoporotic vertebral collapse in patients with Parkinson’s disease

Abstract Osteoporosis and Parkinson’s disease (PD) are age-related diseases, and surgery for osteoporotic vertebral collapse (OVC) in PD patients become more common. OVC commonly affects the thoracolumbar spine, but low lumbar OVC is frequent in patients with lower bone mineral density (BMD). The ai...

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Autores principales:	Hideaki Nakajima, Arisa Kubota, Shuji Watanabe, Kazuya Honjoh, Akihiko Matsumine
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ad0c1876298c454d8cfb91744e225a41
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spelling	oai:doaj.org-article:ad0c1876298c454d8cfb91744e225a412021-12-02T15:23:07ZClinical and imaging features of surgically treated low lumbar osteoporotic vertebral collapse in patients with Parkinson’s disease10.1038/s41598-021-93798-12045-2322https://doaj.org/article/ad0c1876298c454d8cfb91744e225a412021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93798-1https://doaj.org/toc/2045-2322Abstract Osteoporosis and Parkinson’s disease (PD) are age-related diseases, and surgery for osteoporotic vertebral collapse (OVC) in PD patients become more common. OVC commonly affects the thoracolumbar spine, but low lumbar OVC is frequent in patients with lower bone mineral density (BMD). The aim of this study was to identify differences in clinical and imaging features of low lumbar OVC with or without PD and to discuss the appropriate treatment. The subjects were 43 patients with low lumbar OVC below L3 who were treated surgically, including 11 patients with PD. The main clinical symptoms were radicular pain in non-PD cases and a cauda equina sign in PD cases. Rapid progression and destructive changes of OVC were seen in patients with PD. The morphological features of OVC were flat-type in non-PD cases with old compression fracture, and destruction-type in PD cases without old compression fracture. Progression of PD was associated with decreased lumbar lordosis, lower lumbar BMD, and severe sarcopenia. High postoperative complication rates were associated with vertebral fragility and longer fusion surgery. Progression of postural instability as a natural course of PD may lead to mechanical stress and instrumentation failure. Invasive long-fusion surgery should be avoided for single low lumbar OVC.Hideaki NakajimaArisa KubotaShuji WatanabeKazuya HonjohAkihiko MatsumineNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hideaki Nakajima Arisa Kubota Shuji Watanabe Kazuya Honjoh Akihiko Matsumine Clinical and imaging features of surgically treated low lumbar osteoporotic vertebral collapse in patients with Parkinson’s disease
description	Abstract Osteoporosis and Parkinson’s disease (PD) are age-related diseases, and surgery for osteoporotic vertebral collapse (OVC) in PD patients become more common. OVC commonly affects the thoracolumbar spine, but low lumbar OVC is frequent in patients with lower bone mineral density (BMD). The aim of this study was to identify differences in clinical and imaging features of low lumbar OVC with or without PD and to discuss the appropriate treatment. The subjects were 43 patients with low lumbar OVC below L3 who were treated surgically, including 11 patients with PD. The main clinical symptoms were radicular pain in non-PD cases and a cauda equina sign in PD cases. Rapid progression and destructive changes of OVC were seen in patients with PD. The morphological features of OVC were flat-type in non-PD cases with old compression fracture, and destruction-type in PD cases without old compression fracture. Progression of PD was associated with decreased lumbar lordosis, lower lumbar BMD, and severe sarcopenia. High postoperative complication rates were associated with vertebral fragility and longer fusion surgery. Progression of postural instability as a natural course of PD may lead to mechanical stress and instrumentation failure. Invasive long-fusion surgery should be avoided for single low lumbar OVC.
format	article
author	Hideaki Nakajima Arisa Kubota Shuji Watanabe Kazuya Honjoh Akihiko Matsumine
author_facet	Hideaki Nakajima Arisa Kubota Shuji Watanabe Kazuya Honjoh Akihiko Matsumine
author_sort	Hideaki Nakajima
title	Clinical and imaging features of surgically treated low lumbar osteoporotic vertebral collapse in patients with Parkinson’s disease
title_short	Clinical and imaging features of surgically treated low lumbar osteoporotic vertebral collapse in patients with Parkinson’s disease
title_full	Clinical and imaging features of surgically treated low lumbar osteoporotic vertebral collapse in patients with Parkinson’s disease
title_fullStr	Clinical and imaging features of surgically treated low lumbar osteoporotic vertebral collapse in patients with Parkinson’s disease
title_full_unstemmed	Clinical and imaging features of surgically treated low lumbar osteoporotic vertebral collapse in patients with Parkinson’s disease
title_sort	clinical and imaging features of surgically treated low lumbar osteoporotic vertebral collapse in patients with parkinson’s disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ad0c1876298c454d8cfb91744e225a41
work_keys_str_mv	AT hideakinakajima clinicalandimagingfeaturesofsurgicallytreatedlowlumbarosteoporoticvertebralcollapseinpatientswithparkinsonsdisease AT arisakubota clinicalandimagingfeaturesofsurgicallytreatedlowlumbarosteoporoticvertebralcollapseinpatientswithparkinsonsdisease AT shujiwatanabe clinicalandimagingfeaturesofsurgicallytreatedlowlumbarosteoporoticvertebralcollapseinpatientswithparkinsonsdisease AT kazuyahonjoh clinicalandimagingfeaturesofsurgicallytreatedlowlumbarosteoporoticvertebralcollapseinpatientswithparkinsonsdisease AT akihikomatsumine clinicalandimagingfeaturesofsurgicallytreatedlowlumbarosteoporoticvertebralcollapseinpatientswithparkinsonsdisease
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Clinical and imaging features of surgically treated low lumbar osteoporotic vertebral collapse in patients with Parkinson’s disease

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