Actin nucleation at the centrosome controls lymphocyte polarity

Cell polarity is marked by re-orientation of the centrosome, but the mechanisms governing centrosome polarization are poorly understood. Here Obino et al. show that in lymphocytes centrosome-associated Arp2/3 nucleates actin that tethers the centrosome to the nucleus; activation depletes Arp2/3 from...

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Autores principales:	Dorian Obino, Francesca Farina, Odile Malbec, Pablo J. Sáez, Mathieu Maurin, Jérémie Gaillard, Florent Dingli, Damarys Loew, Alexis Gautreau, Maria-Isabel Yuseff, Laurent Blanchoin, Manuel Théry, Ana-Maria Lennon-Duménil
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ad0cead5d3e646b58ced0f3632298203
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spelling	oai:doaj.org-article:ad0cead5d3e646b58ced0f36322982032021-12-02T15:35:00ZActin nucleation at the centrosome controls lymphocyte polarity10.1038/ncomms109692041-1723https://doaj.org/article/ad0cead5d3e646b58ced0f36322982032016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10969https://doaj.org/toc/2041-1723Cell polarity is marked by re-orientation of the centrosome, but the mechanisms governing centrosome polarization are poorly understood. Here Obino et al. show that in lymphocytes centrosome-associated Arp2/3 nucleates actin that tethers the centrosome to the nucleus; activation depletes Arp2/3 from the centrosome and frees it from the nucleus.Dorian ObinoFrancesca FarinaOdile MalbecPablo J. SáezMathieu MaurinJérémie GaillardFlorent DingliDamarys LoewAlexis GautreauMaria-Isabel YuseffLaurent BlanchoinManuel ThéryAna-Maria Lennon-DuménilNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dorian Obino Francesca Farina Odile Malbec Pablo J. Sáez Mathieu Maurin Jérémie Gaillard Florent Dingli Damarys Loew Alexis Gautreau Maria-Isabel Yuseff Laurent Blanchoin Manuel Théry Ana-Maria Lennon-Duménil Actin nucleation at the centrosome controls lymphocyte polarity
description	Cell polarity is marked by re-orientation of the centrosome, but the mechanisms governing centrosome polarization are poorly understood. Here Obino et al. show that in lymphocytes centrosome-associated Arp2/3 nucleates actin that tethers the centrosome to the nucleus; activation depletes Arp2/3 from the centrosome and frees it from the nucleus.
format	article
author	Dorian Obino Francesca Farina Odile Malbec Pablo J. Sáez Mathieu Maurin Jérémie Gaillard Florent Dingli Damarys Loew Alexis Gautreau Maria-Isabel Yuseff Laurent Blanchoin Manuel Théry Ana-Maria Lennon-Duménil
author_facet	Dorian Obino Francesca Farina Odile Malbec Pablo J. Sáez Mathieu Maurin Jérémie Gaillard Florent Dingli Damarys Loew Alexis Gautreau Maria-Isabel Yuseff Laurent Blanchoin Manuel Théry Ana-Maria Lennon-Duménil
author_sort	Dorian Obino
title	Actin nucleation at the centrosome controls lymphocyte polarity
title_short	Actin nucleation at the centrosome controls lymphocyte polarity
title_full	Actin nucleation at the centrosome controls lymphocyte polarity
title_fullStr	Actin nucleation at the centrosome controls lymphocyte polarity
title_full_unstemmed	Actin nucleation at the centrosome controls lymphocyte polarity
title_sort	actin nucleation at the centrosome controls lymphocyte polarity
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/ad0cead5d3e646b58ced0f3632298203
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Actin nucleation at the centrosome controls lymphocyte polarity

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