Mechanisms of Peripheral and Central Pain Sensitization: Focus on Ocular Pain

Persistent ocular pain caused by corneal inflammation and/or nerve injury is accompanied by significant alterations along the pain axis. Both primary sensory neurons in the trigeminal nerves and secondary neurons in the spinal trigeminal nucleus are subjected to profound morphological and functional...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Giulia Puja, Balazs Sonkodi, Rita Bardoni
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	cornea trigeminal ganglion peripheral and central sensitization synaptic transmission descending modulation ocular pain Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/ad1a900692fc44e1abfb5b06866e8432
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ad1a900692fc44e1abfb5b06866e8432
record_format	dspace
spelling	oai:doaj.org-article:ad1a900692fc44e1abfb5b06866e84322021-12-01T18:44:12ZMechanisms of Peripheral and Central Pain Sensitization: Focus on Ocular Pain1663-981210.3389/fphar.2021.764396https://doaj.org/article/ad1a900692fc44e1abfb5b06866e84322021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.764396/fullhttps://doaj.org/toc/1663-9812Persistent ocular pain caused by corneal inflammation and/or nerve injury is accompanied by significant alterations along the pain axis. Both primary sensory neurons in the trigeminal nerves and secondary neurons in the spinal trigeminal nucleus are subjected to profound morphological and functional changes, leading to peripheral and central pain sensitization. Several studies using animal models of inflammatory and neuropathic ocular pain have provided insight about the mechanisms involved in these maladaptive changes. Recently, the advent of new techniques such as optogenetics or genetic neuronal labelling has allowed the investigation of identified circuits involved in nociception, both at the spinal and trigeminal level. In this review, we will describe some of the mechanisms that contribute to the perception of ocular pain at the periphery and at the spinal trigeminal nucleus. Recent advances in the discovery of molecular and cellular mechanisms contributing to peripheral and central pain sensitization of the trigeminal pathways will be also presented.Giulia PujaBalazs SonkodiRita BardoniFrontiers Media S.A.articlecorneatrigeminal ganglionperipheral and central sensitizationsynaptic transmissiondescending modulationocular painTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cornea trigeminal ganglion peripheral and central sensitization synaptic transmission descending modulation ocular pain Therapeutics. Pharmacology RM1-950
spellingShingle	cornea trigeminal ganglion peripheral and central sensitization synaptic transmission descending modulation ocular pain Therapeutics. Pharmacology RM1-950 Giulia Puja Balazs Sonkodi Rita Bardoni Mechanisms of Peripheral and Central Pain Sensitization: Focus on Ocular Pain
description	Persistent ocular pain caused by corneal inflammation and/or nerve injury is accompanied by significant alterations along the pain axis. Both primary sensory neurons in the trigeminal nerves and secondary neurons in the spinal trigeminal nucleus are subjected to profound morphological and functional changes, leading to peripheral and central pain sensitization. Several studies using animal models of inflammatory and neuropathic ocular pain have provided insight about the mechanisms involved in these maladaptive changes. Recently, the advent of new techniques such as optogenetics or genetic neuronal labelling has allowed the investigation of identified circuits involved in nociception, both at the spinal and trigeminal level. In this review, we will describe some of the mechanisms that contribute to the perception of ocular pain at the periphery and at the spinal trigeminal nucleus. Recent advances in the discovery of molecular and cellular mechanisms contributing to peripheral and central pain sensitization of the trigeminal pathways will be also presented.
format	article
author	Giulia Puja Balazs Sonkodi Rita Bardoni
author_facet	Giulia Puja Balazs Sonkodi Rita Bardoni
author_sort	Giulia Puja
title	Mechanisms of Peripheral and Central Pain Sensitization: Focus on Ocular Pain
title_short	Mechanisms of Peripheral and Central Pain Sensitization: Focus on Ocular Pain
title_full	Mechanisms of Peripheral and Central Pain Sensitization: Focus on Ocular Pain
title_fullStr	Mechanisms of Peripheral and Central Pain Sensitization: Focus on Ocular Pain
title_full_unstemmed	Mechanisms of Peripheral and Central Pain Sensitization: Focus on Ocular Pain
title_sort	mechanisms of peripheral and central pain sensitization: focus on ocular pain
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/ad1a900692fc44e1abfb5b06866e8432
work_keys_str_mv	AT giuliapuja mechanismsofperipheralandcentralpainsensitizationfocusonocularpain AT balazssonkodi mechanismsofperipheralandcentralpainsensitizationfocusonocularpain AT ritabardoni mechanismsofperipheralandcentralpainsensitizationfocusonocularpain
_version_	1718404713612836864

Mechanisms of Peripheral and Central Pain Sensitization: Focus on Ocular Pain

Ejemplares similares