Effect of orthokeratology on anisometropia control: A meta-analysis

Background: The effectiveness of orthokeratology in retarding anisometropic progression has been investigated in several small-sample studies. This quantitative analysis aimed to elucidate the efficacy of orthokeratology for anisometropia control. Methods: We searched PubMed, Embase, and Cochrane da...

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Autores principales:	Hou-Ren Tsai, Jen-Hung Wang, Cheng-Jen Chiu
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Anisometropia Anisomyopia Axial length Orthokeratology Ortho-K lens Unilateral myopia Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/ad1af8cfbd584aeb9c0bbe9eedc2d8df
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spelling	oai:doaj.org-article:ad1af8cfbd584aeb9c0bbe9eedc2d8df2021-12-02T04:59:11ZEffect of orthokeratology on anisometropia control: A meta-analysis0929-664610.1016/j.jfma.2021.05.024https://doaj.org/article/ad1af8cfbd584aeb9c0bbe9eedc2d8df2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0929664621002394https://doaj.org/toc/0929-6646Background: The effectiveness of orthokeratology in retarding anisometropic progression has been investigated in several small-sample studies. This quantitative analysis aimed to elucidate the efficacy of orthokeratology for anisometropia control. Methods: We searched PubMed, Embase, and Cochrane databases for relevant studies through September 2020. Axial length (AL) data at baseline and final follow-up were extracted, and AL elongation and difference were calculated. Methodological quality was evaluated using the risk of bias in non-randomized studies of interventions (ROBINS-I) tool. Meta-analyses were performed using a fixed-effect model based on the heterogeneity. Results: A total of 10 cohort studies (nine retrospective studies; one prospective study) were included. The pooled results for the unilateral myopia group showed that the mean AL elongation difference between myopic and emmetropic eyes was −0.27 mm (95% CI, −0.31 to −0.22; p < 0.01) at the one-year follow-up (four studies) and −0.17 mm (95% CI, −0.33 to −0.02; p = 0.03) at the two-year follow-up (two studies). In the bilateral anisomyopic group, mean AL elongation difference between high and low myopic eyes was −0.06 mm (95% CI, −0.09 to −0.04; p < 0.01) at the one-year follow-up (seven studies) and −0.13 mm (95% CI, −0.21 to −0.06; p < 0.01) at the two-year followup (three studies). Conclusion: This study demonstrated that orthokeratology can effectively retard myopic progression and reduce anisomyopic values. However, additional wellstructured randomized controlled trials or prospective studies with longer follow-up periods are warranted to address this topic in more detail.Hou-Ren TsaiJen-Hung WangCheng-Jen ChiuElsevierarticleAnisometropiaAnisomyopiaAxial lengthOrthokeratologyOrtho-K lensUnilateral myopiaMedicine (General)R5-920ENJournal of the Formosan Medical Association, Vol 120, Iss 12, Pp 2120-2127 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Anisometropia Anisomyopia Axial length Orthokeratology Ortho-K lens Unilateral myopia Medicine (General) R5-920
spellingShingle	Anisometropia Anisomyopia Axial length Orthokeratology Ortho-K lens Unilateral myopia Medicine (General) R5-920 Hou-Ren Tsai Jen-Hung Wang Cheng-Jen Chiu Effect of orthokeratology on anisometropia control: A meta-analysis
description	Background: The effectiveness of orthokeratology in retarding anisometropic progression has been investigated in several small-sample studies. This quantitative analysis aimed to elucidate the efficacy of orthokeratology for anisometropia control. Methods: We searched PubMed, Embase, and Cochrane databases for relevant studies through September 2020. Axial length (AL) data at baseline and final follow-up were extracted, and AL elongation and difference were calculated. Methodological quality was evaluated using the risk of bias in non-randomized studies of interventions (ROBINS-I) tool. Meta-analyses were performed using a fixed-effect model based on the heterogeneity. Results: A total of 10 cohort studies (nine retrospective studies; one prospective study) were included. The pooled results for the unilateral myopia group showed that the mean AL elongation difference between myopic and emmetropic eyes was −0.27 mm (95% CI, −0.31 to −0.22; p < 0.01) at the one-year follow-up (four studies) and −0.17 mm (95% CI, −0.33 to −0.02; p = 0.03) at the two-year follow-up (two studies). In the bilateral anisomyopic group, mean AL elongation difference between high and low myopic eyes was −0.06 mm (95% CI, −0.09 to −0.04; p < 0.01) at the one-year follow-up (seven studies) and −0.13 mm (95% CI, −0.21 to −0.06; p < 0.01) at the two-year followup (three studies). Conclusion: This study demonstrated that orthokeratology can effectively retard myopic progression and reduce anisomyopic values. However, additional wellstructured randomized controlled trials or prospective studies with longer follow-up periods are warranted to address this topic in more detail.
format	article
author	Hou-Ren Tsai Jen-Hung Wang Cheng-Jen Chiu
author_facet	Hou-Ren Tsai Jen-Hung Wang Cheng-Jen Chiu
author_sort	Hou-Ren Tsai
title	Effect of orthokeratology on anisometropia control: A meta-analysis
title_short	Effect of orthokeratology on anisometropia control: A meta-analysis
title_full	Effect of orthokeratology on anisometropia control: A meta-analysis
title_fullStr	Effect of orthokeratology on anisometropia control: A meta-analysis
title_full_unstemmed	Effect of orthokeratology on anisometropia control: A meta-analysis
title_sort	effect of orthokeratology on anisometropia control: a meta-analysis
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/ad1af8cfbd584aeb9c0bbe9eedc2d8df
work_keys_str_mv	AT hourentsai effectoforthokeratologyonanisometropiacontrolametaanalysis AT jenhungwang effectoforthokeratologyonanisometropiacontrolametaanalysis AT chengjenchiu effectoforthokeratologyonanisometropiacontrolametaanalysis
_version_	1718400909217628160

Effect of orthokeratology on anisometropia control: A meta-analysis

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