Tendon Tissue Repair in Prospective of Drug Delivery, Regenerative Medicines, and Innovative Bioscaffolds

The natural healing capacity of the tendon tissue is limited due to the hypovascular and cellular nature of this tissue. So far, several conventional approaches have been tested for tendon repair to accelerate the healing process, but all these approaches have their own advantages and limitations. R...

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Autores principales: Muhammad Nadeem Hafeez, Nicola d’Avanzo, Valentina Russo, Luisa Di Marzio, Felisa Cilurzo, Donatella Paolino, Massimo Fresta, Barbara Barboni, Hélder A. Santos, Christian Celia
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Publicado: Hindawi Limited 2021
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Acceso en línea:https://doaj.org/article/ad1f9addbd84430c95d4eae1c9e9157a
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spelling oai:doaj.org-article:ad1f9addbd84430c95d4eae1c9e9157a2021-11-29T00:55:45ZTendon Tissue Repair in Prospective of Drug Delivery, Regenerative Medicines, and Innovative Bioscaffolds1687-967810.1155/2021/1488829https://doaj.org/article/ad1f9addbd84430c95d4eae1c9e9157a2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/1488829https://doaj.org/toc/1687-9678The natural healing capacity of the tendon tissue is limited due to the hypovascular and cellular nature of this tissue. So far, several conventional approaches have been tested for tendon repair to accelerate the healing process, but all these approaches have their own advantages and limitations. Regenerative medicine and tissue engineering are interdisciplinary fields that aspire to develop novel medical devices, innovative bioscaffold, and nanomedicine, by combining different cell sources, biodegradable materials, immune modulators, and nanoparticles for tendon tissue repair. Different studies supported the idea that bioscaffolds can provide an alternative for tendon augmentation with an enormous therapeutic potentiality. However, available data are lacking to allow definitive conclusion on the use of bioscaffolds for tendon regeneration and repairing. In this review, we provide an overview of the current basic understanding and material science in the field of bioscaffolds, nanomedicine, and tissue engineering for tendon repair.Muhammad Nadeem HafeezNicola d’AvanzoValentina RussoLuisa Di MarzioFelisa CilurzoDonatella PaolinoMassimo FrestaBarbara BarboniHélder A. SantosChristian CeliaHindawi LimitedarticleInternal medicineRC31-1245ENStem Cells International, Vol 2021 (2021)
institution DOAJ
collection DOAJ
language EN
topic Internal medicine
RC31-1245
spellingShingle Internal medicine
RC31-1245
Muhammad Nadeem Hafeez
Nicola d’Avanzo
Valentina Russo
Luisa Di Marzio
Felisa Cilurzo
Donatella Paolino
Massimo Fresta
Barbara Barboni
Hélder A. Santos
Christian Celia
Tendon Tissue Repair in Prospective of Drug Delivery, Regenerative Medicines, and Innovative Bioscaffolds
description The natural healing capacity of the tendon tissue is limited due to the hypovascular and cellular nature of this tissue. So far, several conventional approaches have been tested for tendon repair to accelerate the healing process, but all these approaches have their own advantages and limitations. Regenerative medicine and tissue engineering are interdisciplinary fields that aspire to develop novel medical devices, innovative bioscaffold, and nanomedicine, by combining different cell sources, biodegradable materials, immune modulators, and nanoparticles for tendon tissue repair. Different studies supported the idea that bioscaffolds can provide an alternative for tendon augmentation with an enormous therapeutic potentiality. However, available data are lacking to allow definitive conclusion on the use of bioscaffolds for tendon regeneration and repairing. In this review, we provide an overview of the current basic understanding and material science in the field of bioscaffolds, nanomedicine, and tissue engineering for tendon repair.
format article
author Muhammad Nadeem Hafeez
Nicola d’Avanzo
Valentina Russo
Luisa Di Marzio
Felisa Cilurzo
Donatella Paolino
Massimo Fresta
Barbara Barboni
Hélder A. Santos
Christian Celia
author_facet Muhammad Nadeem Hafeez
Nicola d’Avanzo
Valentina Russo
Luisa Di Marzio
Felisa Cilurzo
Donatella Paolino
Massimo Fresta
Barbara Barboni
Hélder A. Santos
Christian Celia
author_sort Muhammad Nadeem Hafeez
title Tendon Tissue Repair in Prospective of Drug Delivery, Regenerative Medicines, and Innovative Bioscaffolds
title_short Tendon Tissue Repair in Prospective of Drug Delivery, Regenerative Medicines, and Innovative Bioscaffolds
title_full Tendon Tissue Repair in Prospective of Drug Delivery, Regenerative Medicines, and Innovative Bioscaffolds
title_fullStr Tendon Tissue Repair in Prospective of Drug Delivery, Regenerative Medicines, and Innovative Bioscaffolds
title_full_unstemmed Tendon Tissue Repair in Prospective of Drug Delivery, Regenerative Medicines, and Innovative Bioscaffolds
title_sort tendon tissue repair in prospective of drug delivery, regenerative medicines, and innovative bioscaffolds
publisher Hindawi Limited
publishDate 2021
url https://doaj.org/article/ad1f9addbd84430c95d4eae1c9e9157a
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