Previous COVID-19 Infection and Antibody Levels After Vaccination

Background: The emergence of new COVID-19 variants of concern coupled with a global inequity in vaccine access and distribution has prompted many public health authorities to circumvent the vaccine shortages by altering vaccination protocols and prioritizing persons at high risk. Individuals with pr...

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Autores principales:	Hamad Ali, Barrak Alahmad, Abdullah A. Al-Shammari, Abdulmohsen Alterki, Maha Hammad, Preethi Cherian, Irina Alkhairi, Sardar Sindhu, Thangavel Alphonse Thanaraj, Anwar Mohammad, Ghazi Alghanim, Sriraman Deverajan, Rasheed Ahmad, Sherief El-Shazly, Ali A. Dashti, Mohammad Shehab, Salman Al-Sabah, Abdullah Alkandari, Jehad Abubaker, Mohamed Abu-Farha, Fahd Al-Mulla
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	COVID-19 SARS-CoV-2 BNT162b2 antibodies humoral response ChAdOx1 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/ad22999c720942c599e5cf90241157d5
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spelling	oai:doaj.org-article:ad22999c720942c599e5cf90241157d52021-12-01T21:34:02ZPrevious COVID-19 Infection and Antibody Levels After Vaccination2296-256510.3389/fpubh.2021.778243https://doaj.org/article/ad22999c720942c599e5cf90241157d52021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fpubh.2021.778243/fullhttps://doaj.org/toc/2296-2565Background: The emergence of new COVID-19 variants of concern coupled with a global inequity in vaccine access and distribution has prompted many public health authorities to circumvent the vaccine shortages by altering vaccination protocols and prioritizing persons at high risk. Individuals with previous COVID-19 infection may not have been prioritized due to existing humoral immunity.Objective: We aimed to study the association between previous COVID-19 infection and antibody levels after COVID-19 vaccination.Methods: A serological analysis to measure SARS-CoV-2 immunoglobulin (Ig)G, IgA, and neutralizing antibodies was performed on individuals who received one or two doses of either BNT162b2 or ChAdOx1 vaccines in Kuwait. A Student t-test was performed and followed by generalized linear regression models adjusted for individual characteristics and comorbidities were fitted to compare the average levels of IgG and neutralizing antibodies between vaccinated individuals with and without previous COVID-19 infection.Results: A total of 1,025 individuals were recruited. The mean levels of IgG, IgA, and neutralizing antibodies were higher in vaccinated subjects with previous COVID-19 infections than in those without previous infection. Regression analysis showed a steeper slope of decline for IgG and neutralizing antibodies in vaccinated individuals without previous COVID-19 infection compared to those with previous COVID-19 infection.Conclusion: Previous COVID-19 infection appeared to elicit robust and sustained levels of SARS-CoV-2 antibodies in vaccinated individuals. Given the inconsistent supply of COVID-19 vaccines in many countries due to inequities in global distribution, our results suggest that even greater efforts should be made to vaccinate more people, especially individuals without previous COVID-19 infection.Hamad AliHamad AliBarrak AlahmadAbdullah A. Al-ShammariAbdullah A. Al-ShammariAbdulmohsen AlterkiAbdulmohsen AlterkiMaha HammadPreethi CherianIrina AlkhairiSardar SindhuThangavel Alphonse ThanarajAnwar MohammadGhazi AlghanimSriraman DeverajanRasheed AhmadSherief El-ShazlyAli A. DashtiMohammad ShehabSalman Al-SabahAbdullah AlkandariJehad AbubakerMohamed Abu-FarhaFahd Al-MullaFrontiers Media S.A.articleCOVID-19SARS-CoV-2BNT162b2antibodieshumoral responseChAdOx1Public aspects of medicineRA1-1270ENFrontiers in Public Health, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 SARS-CoV-2 BNT162b2 antibodies humoral response ChAdOx1 Public aspects of medicine RA1-1270
spellingShingle	COVID-19 SARS-CoV-2 BNT162b2 antibodies humoral response ChAdOx1 Public aspects of medicine RA1-1270 Hamad Ali Hamad Ali Barrak Alahmad Abdullah A. Al-Shammari Abdullah A. Al-Shammari Abdulmohsen Alterki Abdulmohsen Alterki Maha Hammad Preethi Cherian Irina Alkhairi Sardar Sindhu Thangavel Alphonse Thanaraj Anwar Mohammad Ghazi Alghanim Sriraman Deverajan Rasheed Ahmad Sherief El-Shazly Ali A. Dashti Mohammad Shehab Salman Al-Sabah Abdullah Alkandari Jehad Abubaker Mohamed Abu-Farha Fahd Al-Mulla Previous COVID-19 Infection and Antibody Levels After Vaccination
description	Background: The emergence of new COVID-19 variants of concern coupled with a global inequity in vaccine access and distribution has prompted many public health authorities to circumvent the vaccine shortages by altering vaccination protocols and prioritizing persons at high risk. Individuals with previous COVID-19 infection may not have been prioritized due to existing humoral immunity.Objective: We aimed to study the association between previous COVID-19 infection and antibody levels after COVID-19 vaccination.Methods: A serological analysis to measure SARS-CoV-2 immunoglobulin (Ig)G, IgA, and neutralizing antibodies was performed on individuals who received one or two doses of either BNT162b2 or ChAdOx1 vaccines in Kuwait. A Student t-test was performed and followed by generalized linear regression models adjusted for individual characteristics and comorbidities were fitted to compare the average levels of IgG and neutralizing antibodies between vaccinated individuals with and without previous COVID-19 infection.Results: A total of 1,025 individuals were recruited. The mean levels of IgG, IgA, and neutralizing antibodies were higher in vaccinated subjects with previous COVID-19 infections than in those without previous infection. Regression analysis showed a steeper slope of decline for IgG and neutralizing antibodies in vaccinated individuals without previous COVID-19 infection compared to those with previous COVID-19 infection.Conclusion: Previous COVID-19 infection appeared to elicit robust and sustained levels of SARS-CoV-2 antibodies in vaccinated individuals. Given the inconsistent supply of COVID-19 vaccines in many countries due to inequities in global distribution, our results suggest that even greater efforts should be made to vaccinate more people, especially individuals without previous COVID-19 infection.
format	article
author	Hamad Ali Hamad Ali Barrak Alahmad Abdullah A. Al-Shammari Abdullah A. Al-Shammari Abdulmohsen Alterki Abdulmohsen Alterki Maha Hammad Preethi Cherian Irina Alkhairi Sardar Sindhu Thangavel Alphonse Thanaraj Anwar Mohammad Ghazi Alghanim Sriraman Deverajan Rasheed Ahmad Sherief El-Shazly Ali A. Dashti Mohammad Shehab Salman Al-Sabah Abdullah Alkandari Jehad Abubaker Mohamed Abu-Farha Fahd Al-Mulla
author_facet	Hamad Ali Hamad Ali Barrak Alahmad Abdullah A. Al-Shammari Abdullah A. Al-Shammari Abdulmohsen Alterki Abdulmohsen Alterki Maha Hammad Preethi Cherian Irina Alkhairi Sardar Sindhu Thangavel Alphonse Thanaraj Anwar Mohammad Ghazi Alghanim Sriraman Deverajan Rasheed Ahmad Sherief El-Shazly Ali A. Dashti Mohammad Shehab Salman Al-Sabah Abdullah Alkandari Jehad Abubaker Mohamed Abu-Farha Fahd Al-Mulla
author_sort	Hamad Ali
title	Previous COVID-19 Infection and Antibody Levels After Vaccination
title_short	Previous COVID-19 Infection and Antibody Levels After Vaccination
title_full	Previous COVID-19 Infection and Antibody Levels After Vaccination
title_fullStr	Previous COVID-19 Infection and Antibody Levels After Vaccination
title_full_unstemmed	Previous COVID-19 Infection and Antibody Levels After Vaccination
title_sort	previous covid-19 infection and antibody levels after vaccination
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/ad22999c720942c599e5cf90241157d5
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Previous COVID-19 Infection and Antibody Levels After Vaccination

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