mTORC1 and PKB/Akt control the muscle response to denervation by regulating autophagy and HDAC4
Denervation leads to muscle atrophy and neuromuscular endplate remodeling. Here, the authors show that a balanced activation of mTORC1 contributes to the dynamic regulation of autophagic flux in denervated muscle and that activation of PKB/Akt promotes the nuclear import of HDAC4, which is essential...
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Nature Portfolio
2019
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oai:doaj.org-article:ad2327d58d6a49b7a54e496210a1a5f22021-12-02T17:01:28ZmTORC1 and PKB/Akt control the muscle response to denervation by regulating autophagy and HDAC410.1038/s41467-019-11227-42041-1723https://doaj.org/article/ad2327d58d6a49b7a54e496210a1a5f22019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11227-4https://doaj.org/toc/2041-1723Denervation leads to muscle atrophy and neuromuscular endplate remodeling. Here, the authors show that a balanced activation of mTORC1 contributes to the dynamic regulation of autophagic flux in denervated muscle and that activation of PKB/Akt promotes the nuclear import of HDAC4, which is essential for endplate maintenance upon nerve injuryPerrine CastetsNathalie RionMarine ThéodoreDenis FalcettaShuo LinMarkus ReischlFranziska WildLaurent GuérardChristopher EickhorstMarielle BrockhoffMaitea GuridiChikwendu IbebunjoJoseph CruzMichael SinnreichRüdiger RudolfDavid J. GlassMarkus A. RüeggNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019) |
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DOAJ |
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| language |
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| topic |
Science Q |
| spellingShingle |
Science Q Perrine Castets Nathalie Rion Marine Théodore Denis Falcetta Shuo Lin Markus Reischl Franziska Wild Laurent Guérard Christopher Eickhorst Marielle Brockhoff Maitea Guridi Chikwendu Ibebunjo Joseph Cruz Michael Sinnreich Rüdiger Rudolf David J. Glass Markus A. Rüegg mTORC1 and PKB/Akt control the muscle response to denervation by regulating autophagy and HDAC4 |
| description |
Denervation leads to muscle atrophy and neuromuscular endplate remodeling. Here, the authors show that a balanced activation of mTORC1 contributes to the dynamic regulation of autophagic flux in denervated muscle and that activation of PKB/Akt promotes the nuclear import of HDAC4, which is essential for endplate maintenance upon nerve injury |
| format |
article |
| author |
Perrine Castets Nathalie Rion Marine Théodore Denis Falcetta Shuo Lin Markus Reischl Franziska Wild Laurent Guérard Christopher Eickhorst Marielle Brockhoff Maitea Guridi Chikwendu Ibebunjo Joseph Cruz Michael Sinnreich Rüdiger Rudolf David J. Glass Markus A. Rüegg |
| author_facet |
Perrine Castets Nathalie Rion Marine Théodore Denis Falcetta Shuo Lin Markus Reischl Franziska Wild Laurent Guérard Christopher Eickhorst Marielle Brockhoff Maitea Guridi Chikwendu Ibebunjo Joseph Cruz Michael Sinnreich Rüdiger Rudolf David J. Glass Markus A. Rüegg |
| author_sort |
Perrine Castets |
| title |
mTORC1 and PKB/Akt control the muscle response to denervation by regulating autophagy and HDAC4 |
| title_short |
mTORC1 and PKB/Akt control the muscle response to denervation by regulating autophagy and HDAC4 |
| title_full |
mTORC1 and PKB/Akt control the muscle response to denervation by regulating autophagy and HDAC4 |
| title_fullStr |
mTORC1 and PKB/Akt control the muscle response to denervation by regulating autophagy and HDAC4 |
| title_full_unstemmed |
mTORC1 and PKB/Akt control the muscle response to denervation by regulating autophagy and HDAC4 |
| title_sort |
mtorc1 and pkb/akt control the muscle response to denervation by regulating autophagy and hdac4 |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/ad2327d58d6a49b7a54e496210a1a5f2 |
| work_keys_str_mv |
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| _version_ |
1718382168393121792 |