Zika Virus Infection and Microcephaly: A Case-Control Study in Brazil

Background: Brazil presented an alarming number of newborns with microcephaly in the years 2015 and 2016. The investigation of the cases raised the suspicion of the association of these cases with maternal infections by the zika virus. Also, in 2015, there was an epidemic of zika virus infection in...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sabrina Gabriele Maia Oliveira Rocha, Luciano Lima Correia, Antônio José Lêdo Alves da Cunha, Hermano Alexandre Lima Rocha, Álvaro Jorge Madeiro Leite, Jocileide Sales Campos, Tereza de Jesus Pinheiro Gomes Bandeira, Lucas Silveira do Nascimento, Anamaria Cavalcante e Silva
Formato:	article
Lenguaje:	EN
Publicado:	Ubiquity Press 2019
Materias:	Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/ad24cc44d5ed4c21915c862cd1bff728
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ad24cc44d5ed4c21915c862cd1bff728
record_format	dspace
spelling	oai:doaj.org-article:ad24cc44d5ed4c21915c862cd1bff7282021-12-02T05:21:26ZZika Virus Infection and Microcephaly: A Case-Control Study in Brazil2214-999610.5334/aogh.2394https://doaj.org/article/ad24cc44d5ed4c21915c862cd1bff7282019-08-01T00:00:00Zhttps://annalsofglobalhealth.org/articles/2394https://doaj.org/toc/2214-9996Background: Brazil presented an alarming number of newborns with microcephaly in the years 2015 and 2016. The investigation of the cases raised the suspicion of the association of these cases with maternal infections by the zika virus. Also, in 2015, there was an epidemic of zika virus infection in Brazil, reinforcing this hypothesis. Objective: The objective of this study was to identify factors associated with the diagnosis of microcephaly in newborns, including zika virus infection. Methods: We conducted a case-control study. The cases were defined as children who received clinical and imaging diagnosis of microcephaly, born after October 2015 in Ceará, Brazil, which recorded the highest number of microcephaly cases in Brazil during the outbreak. The cases were identified in medical records of public and private maternity hospitals and in child development stimulation clinics tracked until June 2017. Epidemiological, clinical, and socioeconomic variables were collected, visiting their homes and confirming data from their medical records. Controls were children without microcephaly identified in the vicinity of the residence of each case. Logistic regression models were used to control confounding. Findings: We evaluated 58 cases and 116 controls. The odds of having a baby with microcephaly was 14 times higher among mothers who had zika virus infection (p < 0.001), after multivariate analysis. Arboviruses infections symptoms, as fever (p = 0.220), skin change (p < 0.001), and joint pain (p = 0.002) also demonstrated an association with microcephaly. Conclusions: Maternal infection zika virus was associated with a diagnosis of microcephaly. Our study contributes to the investigation of the epidemiological factors associated with the diagnosis of microcephaly.Sabrina Gabriele Maia Oliveira RochaLuciano Lima CorreiaAntônio José Lêdo Alves da CunhaHermano Alexandre Lima RochaÁlvaro Jorge Madeiro LeiteJocileide Sales CamposTereza de Jesus Pinheiro Gomes BandeiraLucas Silveira do NascimentoAnamaria Cavalcante e SilvaUbiquity PressarticleInfectious and parasitic diseasesRC109-216Public aspects of medicineRA1-1270ENAnnals of Global Health, Vol 85, Iss 1 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270
spellingShingle	Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270 Sabrina Gabriele Maia Oliveira Rocha Luciano Lima Correia Antônio José Lêdo Alves da Cunha Hermano Alexandre Lima Rocha Álvaro Jorge Madeiro Leite Jocileide Sales Campos Tereza de Jesus Pinheiro Gomes Bandeira Lucas Silveira do Nascimento Anamaria Cavalcante e Silva Zika Virus Infection and Microcephaly: A Case-Control Study in Brazil
description	Background: Brazil presented an alarming number of newborns with microcephaly in the years 2015 and 2016. The investigation of the cases raised the suspicion of the association of these cases with maternal infections by the zika virus. Also, in 2015, there was an epidemic of zika virus infection in Brazil, reinforcing this hypothesis. Objective: The objective of this study was to identify factors associated with the diagnosis of microcephaly in newborns, including zika virus infection. Methods: We conducted a case-control study. The cases were defined as children who received clinical and imaging diagnosis of microcephaly, born after October 2015 in Ceará, Brazil, which recorded the highest number of microcephaly cases in Brazil during the outbreak. The cases were identified in medical records of public and private maternity hospitals and in child development stimulation clinics tracked until June 2017. Epidemiological, clinical, and socioeconomic variables were collected, visiting their homes and confirming data from their medical records. Controls were children without microcephaly identified in the vicinity of the residence of each case. Logistic regression models were used to control confounding. Findings: We evaluated 58 cases and 116 controls. The odds of having a baby with microcephaly was 14 times higher among mothers who had zika virus infection (p < 0.001), after multivariate analysis. Arboviruses infections symptoms, as fever (p = 0.220), skin change (p < 0.001), and joint pain (p = 0.002) also demonstrated an association with microcephaly. Conclusions: Maternal infection zika virus was associated with a diagnosis of microcephaly. Our study contributes to the investigation of the epidemiological factors associated with the diagnosis of microcephaly.
format	article
author	Sabrina Gabriele Maia Oliveira Rocha Luciano Lima Correia Antônio José Lêdo Alves da Cunha Hermano Alexandre Lima Rocha Álvaro Jorge Madeiro Leite Jocileide Sales Campos Tereza de Jesus Pinheiro Gomes Bandeira Lucas Silveira do Nascimento Anamaria Cavalcante e Silva
author_facet	Sabrina Gabriele Maia Oliveira Rocha Luciano Lima Correia Antônio José Lêdo Alves da Cunha Hermano Alexandre Lima Rocha Álvaro Jorge Madeiro Leite Jocileide Sales Campos Tereza de Jesus Pinheiro Gomes Bandeira Lucas Silveira do Nascimento Anamaria Cavalcante e Silva
author_sort	Sabrina Gabriele Maia Oliveira Rocha
title	Zika Virus Infection and Microcephaly: A Case-Control Study in Brazil
title_short	Zika Virus Infection and Microcephaly: A Case-Control Study in Brazil
title_full	Zika Virus Infection and Microcephaly: A Case-Control Study in Brazil
title_fullStr	Zika Virus Infection and Microcephaly: A Case-Control Study in Brazil
title_full_unstemmed	Zika Virus Infection and Microcephaly: A Case-Control Study in Brazil
title_sort	zika virus infection and microcephaly: a case-control study in brazil
publisher	Ubiquity Press
publishDate	2019
url	https://doaj.org/article/ad24cc44d5ed4c21915c862cd1bff728
work_keys_str_mv	AT sabrinagabrielemaiaoliveirarocha zikavirusinfectionandmicrocephalyacasecontrolstudyinbrazil AT lucianolimacorreia zikavirusinfectionandmicrocephalyacasecontrolstudyinbrazil AT antoniojoseledoalvesdacunha zikavirusinfectionandmicrocephalyacasecontrolstudyinbrazil AT hermanoalexandrelimarocha zikavirusinfectionandmicrocephalyacasecontrolstudyinbrazil AT alvarojorgemadeiroleite zikavirusinfectionandmicrocephalyacasecontrolstudyinbrazil AT jocileidesalescampos zikavirusinfectionandmicrocephalyacasecontrolstudyinbrazil AT terezadejesuspinheirogomesbandeira zikavirusinfectionandmicrocephalyacasecontrolstudyinbrazil AT lucassilveiradonascimento zikavirusinfectionandmicrocephalyacasecontrolstudyinbrazil AT anamariacavalcanteesilva zikavirusinfectionandmicrocephalyacasecontrolstudyinbrazil
_version_	1718400434631081984

Zika Virus Infection and Microcephaly: A Case-Control Study in Brazil

Ejemplares similares