Quercetin nanoparticle complex attenuated diabetic nephropathy via regulating the expression level of ICAM-1 on endothelium

Fei Tong,1,2 Suhuan Liu,1 Bing Yan,1 Xuejun Li,1 Shiwei Ruan,3 Shuyu Yang1 1Department of Endocrinology and Diabetes, The First Affiliated Hospital, Xiamen University, Xiamen, 2Department of Pathology and Pathophysiology, Provincial Key Discipline of Pharmacology, Jiaxing University Medical College...

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Autores principales:	Tong F, Liu S, Yan B, Li X, Ruan S, Yang S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	nanoparticle complex quercetin DN ICAM-1 CD11b+ Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/ad29b133b5814f70ade240dd7d4b6f4c
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spelling	oai:doaj.org-article:ad29b133b5814f70ade240dd7d4b6f4c2021-12-02T02:10:26ZQuercetin nanoparticle complex attenuated diabetic nephropathy via regulating the expression level of ICAM-1 on endothelium1178-2013https://doaj.org/article/ad29b133b5814f70ade240dd7d4b6f4c2017-10-01T00:00:00Zhttps://www.dovepress.com/quercetin-nanoparticle-complex-attenuated-diabetic-nephropathy-via-reg-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Fei Tong,1,2 Suhuan Liu,1 Bing Yan,1 Xuejun Li,1 Shiwei Ruan,3 Shuyu Yang1 1Department of Endocrinology and Diabetes, The First Affiliated Hospital, Xiamen University, Xiamen, 2Department of Pathology and Pathophysiology, Provincial Key Discipline of Pharmacology, Jiaxing University Medical College, Jiaxing, Zhejiang, 3Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, People’s Republic of China Abstract: The purpose of the study was to reveal the therapeutic effect of quercetin (QUE) nanoparticle complex on diabetic nephropathy (DN) by regulating the expression of intercellular adhesion molecular-1 (ICAM-1) on endothelium as compared to free QUE. QUE 10 mg/kg as a single abdominal subcutaneous injection daily for 8 weeks continuously in diabetic rats and 10 mg/kg QUE nanoparticle complex as a single abdominal subcutaneous injection every 5 days, continuously administered for 8 weeks to diabetic rats. Blood and left kidneys were collected; pathological change of kidney, renal function, oxidative stress level, blood glucose level, serum lipid, urine protein, and albumin/creatinine ratio were measured; and neutrophil adhesion, ICAM-1 expression, and CD11b+ cells infiltration were observed. Both QUE and QUE nanoparticle complex preconditioning ameliorated the pathological damage of kidney and improved renal function, alleviated renal oxidative stress injury, restricted inflammatory cells infiltration, and downregulated the ICAM-1 expression as compared to DN group, while QUE nanoparticle complex significantly alleviated this effect. Keywords: nanoparticle complex, quercetin, DN, ICAM-1, CD11b+, endotheliumTong FLiu SYan BLi XRuan SYang SDove Medical Pressarticlenanoparticle complexquercetinDNICAM-1CD11b+Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 7799-7813 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	nanoparticle complex quercetin DN ICAM-1 CD11b+ Medicine (General) R5-920
spellingShingle	nanoparticle complex quercetin DN ICAM-1 CD11b+ Medicine (General) R5-920 Tong F Liu S Yan B Li X Ruan S Yang S Quercetin nanoparticle complex attenuated diabetic nephropathy via regulating the expression level of ICAM-1 on endothelium
description	Fei Tong,1,2 Suhuan Liu,1 Bing Yan,1 Xuejun Li,1 Shiwei Ruan,3 Shuyu Yang1 1Department of Endocrinology and Diabetes, The First Affiliated Hospital, Xiamen University, Xiamen, 2Department of Pathology and Pathophysiology, Provincial Key Discipline of Pharmacology, Jiaxing University Medical College, Jiaxing, Zhejiang, 3Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, People’s Republic of China Abstract: The purpose of the study was to reveal the therapeutic effect of quercetin (QUE) nanoparticle complex on diabetic nephropathy (DN) by regulating the expression of intercellular adhesion molecular-1 (ICAM-1) on endothelium as compared to free QUE. QUE 10 mg/kg as a single abdominal subcutaneous injection daily for 8 weeks continuously in diabetic rats and 10 mg/kg QUE nanoparticle complex as a single abdominal subcutaneous injection every 5 days, continuously administered for 8 weeks to diabetic rats. Blood and left kidneys were collected; pathological change of kidney, renal function, oxidative stress level, blood glucose level, serum lipid, urine protein, and albumin/creatinine ratio were measured; and neutrophil adhesion, ICAM-1 expression, and CD11b+ cells infiltration were observed. Both QUE and QUE nanoparticle complex preconditioning ameliorated the pathological damage of kidney and improved renal function, alleviated renal oxidative stress injury, restricted inflammatory cells infiltration, and downregulated the ICAM-1 expression as compared to DN group, while QUE nanoparticle complex significantly alleviated this effect. Keywords: nanoparticle complex, quercetin, DN, ICAM-1, CD11b+, endothelium
format	article
author	Tong F Liu S Yan B Li X Ruan S Yang S
author_facet	Tong F Liu S Yan B Li X Ruan S Yang S
author_sort	Tong F
title	Quercetin nanoparticle complex attenuated diabetic nephropathy via regulating the expression level of ICAM-1 on endothelium
title_short	Quercetin nanoparticle complex attenuated diabetic nephropathy via regulating the expression level of ICAM-1 on endothelium
title_full	Quercetin nanoparticle complex attenuated diabetic nephropathy via regulating the expression level of ICAM-1 on endothelium
title_fullStr	Quercetin nanoparticle complex attenuated diabetic nephropathy via regulating the expression level of ICAM-1 on endothelium
title_full_unstemmed	Quercetin nanoparticle complex attenuated diabetic nephropathy via regulating the expression level of ICAM-1 on endothelium
title_sort	quercetin nanoparticle complex attenuated diabetic nephropathy via regulating the expression level of icam-1 on endothelium
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/ad29b133b5814f70ade240dd7d4b6f4c
work_keys_str_mv	AT tongf quercetinnanoparticlecomplexattenuateddiabeticnephropathyviaregulatingtheexpressionleveloficam1onendothelium AT lius quercetinnanoparticlecomplexattenuateddiabeticnephropathyviaregulatingtheexpressionleveloficam1onendothelium AT yanb quercetinnanoparticlecomplexattenuateddiabeticnephropathyviaregulatingtheexpressionleveloficam1onendothelium AT lix quercetinnanoparticlecomplexattenuateddiabeticnephropathyviaregulatingtheexpressionleveloficam1onendothelium AT ruans quercetinnanoparticlecomplexattenuateddiabeticnephropathyviaregulatingtheexpressionleveloficam1onendothelium AT yangs quercetinnanoparticlecomplexattenuateddiabeticnephropathyviaregulatingtheexpressionleveloficam1onendothelium
_version_	1718402669195821056

Quercetin nanoparticle complex attenuated diabetic nephropathy via regulating the expression level of ICAM-1 on endothelium

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