Changes in abdominal subcutaneous adipose tissue phenotype following menopause is associated with increased visceral fat mass

Abstract Menopause is associated with a redistribution of adipose tissue towards central adiposity, known to cause insulin resistance. In this cross-sectional study of 33 women between 45 and 60 years, we assessed adipose tissue inflammation and morphology in subcutaneous adipose tissue (SAT) and vi...

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Autores principales:	Julie Abildgaard, Thorkil Ploug, Elaf Al-Saoudi, Thomas Wagner, Carsten Thomsen, Caroline Ewertsen, Michael Bzorek, Bente Klarlund Pedersen, Anette Tønnes Pedersen, Birgitte Lindegaard
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ad2ad04d0aa74a39bb472bf351628b8f
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spelling	oai:doaj.org-article:ad2ad04d0aa74a39bb472bf351628b8f2021-12-02T17:55:04ZChanges in abdominal subcutaneous adipose tissue phenotype following menopause is associated with increased visceral fat mass10.1038/s41598-021-94189-22045-2322https://doaj.org/article/ad2ad04d0aa74a39bb472bf351628b8f2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94189-2https://doaj.org/toc/2045-2322Abstract Menopause is associated with a redistribution of adipose tissue towards central adiposity, known to cause insulin resistance. In this cross-sectional study of 33 women between 45 and 60 years, we assessed adipose tissue inflammation and morphology in subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) across menopause and related this to menopausal differences in adipose tissue distribution and insulin resistance. We collected paired SAT and VAT biopsies from all women and combined this with anthropometric measurements and estimated whole-body insulin sensitivity. We found that menopause was associated with changes in adipose tissue phenotype related to metabolic dysfunction. In SAT, postmenopausal women showed adipocyte hypertrophy, increased inflammation, hypoxia and fibrosis. The postmenopausal changes in SAT was associated with increased visceral fat accumulation. In VAT, menopause was associated with adipocyte hypertrophy, immune cell infiltration and fibrosis. The postmenopausal changes in VAT phenotype was associated with decreased insulin sensitivity. Based on these findings we suggest, that menopause is associated with changes in adipose tissue phenotype related to metabolic dysfunction in both SAT and VAT. Whereas increased SAT inflammation in the context of menopause is associated with VAT accumulation, VAT morphology is related to insulin resistance.Julie AbildgaardThorkil PlougElaf Al-SaoudiThomas WagnerCarsten ThomsenCaroline EwertsenMichael BzorekBente Klarlund PedersenAnette Tønnes PedersenBirgitte LindegaardNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Julie Abildgaard Thorkil Ploug Elaf Al-Saoudi Thomas Wagner Carsten Thomsen Caroline Ewertsen Michael Bzorek Bente Klarlund Pedersen Anette Tønnes Pedersen Birgitte Lindegaard Changes in abdominal subcutaneous adipose tissue phenotype following menopause is associated with increased visceral fat mass
description	Abstract Menopause is associated with a redistribution of adipose tissue towards central adiposity, known to cause insulin resistance. In this cross-sectional study of 33 women between 45 and 60 years, we assessed adipose tissue inflammation and morphology in subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) across menopause and related this to menopausal differences in adipose tissue distribution and insulin resistance. We collected paired SAT and VAT biopsies from all women and combined this with anthropometric measurements and estimated whole-body insulin sensitivity. We found that menopause was associated with changes in adipose tissue phenotype related to metabolic dysfunction. In SAT, postmenopausal women showed adipocyte hypertrophy, increased inflammation, hypoxia and fibrosis. The postmenopausal changes in SAT was associated with increased visceral fat accumulation. In VAT, menopause was associated with adipocyte hypertrophy, immune cell infiltration and fibrosis. The postmenopausal changes in VAT phenotype was associated with decreased insulin sensitivity. Based on these findings we suggest, that menopause is associated with changes in adipose tissue phenotype related to metabolic dysfunction in both SAT and VAT. Whereas increased SAT inflammation in the context of menopause is associated with VAT accumulation, VAT morphology is related to insulin resistance.
format	article
author	Julie Abildgaard Thorkil Ploug Elaf Al-Saoudi Thomas Wagner Carsten Thomsen Caroline Ewertsen Michael Bzorek Bente Klarlund Pedersen Anette Tønnes Pedersen Birgitte Lindegaard
author_facet	Julie Abildgaard Thorkil Ploug Elaf Al-Saoudi Thomas Wagner Carsten Thomsen Caroline Ewertsen Michael Bzorek Bente Klarlund Pedersen Anette Tønnes Pedersen Birgitte Lindegaard
author_sort	Julie Abildgaard
title	Changes in abdominal subcutaneous adipose tissue phenotype following menopause is associated with increased visceral fat mass
title_short	Changes in abdominal subcutaneous adipose tissue phenotype following menopause is associated with increased visceral fat mass
title_full	Changes in abdominal subcutaneous adipose tissue phenotype following menopause is associated with increased visceral fat mass
title_fullStr	Changes in abdominal subcutaneous adipose tissue phenotype following menopause is associated with increased visceral fat mass
title_full_unstemmed	Changes in abdominal subcutaneous adipose tissue phenotype following menopause is associated with increased visceral fat mass
title_sort	changes in abdominal subcutaneous adipose tissue phenotype following menopause is associated with increased visceral fat mass
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ad2ad04d0aa74a39bb472bf351628b8f
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Changes in abdominal subcutaneous adipose tissue phenotype following menopause is associated with increased visceral fat mass

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