The Brainstem-Informed Autism Framework: Early Life Neurobehavioral Markers

Autism spectrum disorders (ASD) have long-term implications on functioning at multiple levels. In this perspective, we offer a brainstem-informed autism framework (BIAF) that traces the protracted neurobehavioral manifestations of ASD to early life brainstem dysfunctions. Early life brainstem-mediat...

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Autores principales:	Or Burstein, Ronny Geva
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	autism spectrum disorders (ASD) brainstem auditory brainstem evoked response (ABR) respiratory sinus arrhythmia (RSA) sleep sensory processing Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/ad2c8ecacf7f4569a4d715eadf393584
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spelling	oai:doaj.org-article:ad2c8ecacf7f4569a4d715eadf3935842021-11-10T06:36:26ZThe Brainstem-Informed Autism Framework: Early Life Neurobehavioral Markers1662-514510.3389/fnint.2021.759614https://doaj.org/article/ad2c8ecacf7f4569a4d715eadf3935842021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnint.2021.759614/fullhttps://doaj.org/toc/1662-5145Autism spectrum disorders (ASD) have long-term implications on functioning at multiple levels. In this perspective, we offer a brainstem-informed autism framework (BIAF) that traces the protracted neurobehavioral manifestations of ASD to early life brainstem dysfunctions. Early life brainstem-mediated markers involving functions of autonomic/arousal regulation, sleep-wake homeostasis, and sensorimotor integration are delineated. Their possible contributions to the early identification of susceptible infants are discussed. We suggest that the BIAF expands our multidimensional understanding of ASD by focusing on the early involvement of brainstem systems. Importantly, we propose an integrated BIAF screener that brings about the prospect of a sensitive and reliable early life diagnostic scheme for weighing the risk for ASD. The BIAF screener could provide clinicians substantial gains in the future and may carve customized interventions long before the current DSM ASD phenotype is manifested using dyadic co-regulation of brainstem-informed autism markers.Or BursteinRonny GevaRonny GevaFrontiers Media S.A.articleautism spectrum disorders (ASD)brainstemauditory brainstem evoked response (ABR)respiratory sinus arrhythmia (RSA)sleepsensory processingNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENFrontiers in Integrative Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	autism spectrum disorders (ASD) brainstem auditory brainstem evoked response (ABR) respiratory sinus arrhythmia (RSA) sleep sensory processing Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	autism spectrum disorders (ASD) brainstem auditory brainstem evoked response (ABR) respiratory sinus arrhythmia (RSA) sleep sensory processing Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Or Burstein Ronny Geva Ronny Geva The Brainstem-Informed Autism Framework: Early Life Neurobehavioral Markers
description	Autism spectrum disorders (ASD) have long-term implications on functioning at multiple levels. In this perspective, we offer a brainstem-informed autism framework (BIAF) that traces the protracted neurobehavioral manifestations of ASD to early life brainstem dysfunctions. Early life brainstem-mediated markers involving functions of autonomic/arousal regulation, sleep-wake homeostasis, and sensorimotor integration are delineated. Their possible contributions to the early identification of susceptible infants are discussed. We suggest that the BIAF expands our multidimensional understanding of ASD by focusing on the early involvement of brainstem systems. Importantly, we propose an integrated BIAF screener that brings about the prospect of a sensitive and reliable early life diagnostic scheme for weighing the risk for ASD. The BIAF screener could provide clinicians substantial gains in the future and may carve customized interventions long before the current DSM ASD phenotype is manifested using dyadic co-regulation of brainstem-informed autism markers.
format	article
author	Or Burstein Ronny Geva Ronny Geva
author_facet	Or Burstein Ronny Geva Ronny Geva
author_sort	Or Burstein
title	The Brainstem-Informed Autism Framework: Early Life Neurobehavioral Markers
title_short	The Brainstem-Informed Autism Framework: Early Life Neurobehavioral Markers
title_full	The Brainstem-Informed Autism Framework: Early Life Neurobehavioral Markers
title_fullStr	The Brainstem-Informed Autism Framework: Early Life Neurobehavioral Markers
title_full_unstemmed	The Brainstem-Informed Autism Framework: Early Life Neurobehavioral Markers
title_sort	brainstem-informed autism framework: early life neurobehavioral markers
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/ad2c8ecacf7f4569a4d715eadf393584
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The Brainstem-Informed Autism Framework: Early Life Neurobehavioral Markers

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