Host mitochondrial transcriptome response to SARS-CoV-2 in multiple cell models and clinical samples

Abstract SARS-CoV-2 induces a muted innate immune response compared to other respiratory viruses. Mitochondrial dynamics might partially mediate this effect of SARS-CoV-2 on innate immunity. Polypeptides encoded by open reading frames of SARS-CoV and SARS-CoV-2 have been shown to localize to mitocho...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Brendan Miller, Ana Silverstein, Melanie Flores, Kevin Cao, Hiroshi Kumagai, Hemal H. Mehta, Kelvin Yen, Su- Jeong Kim, Pinchas Cohen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ad2cd95d5924471fa2c8522a8e192362
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ad2cd95d5924471fa2c8522a8e192362
record_format	dspace
spelling	oai:doaj.org-article:ad2cd95d5924471fa2c8522a8e1923622021-12-02T11:46:00ZHost mitochondrial transcriptome response to SARS-CoV-2 in multiple cell models and clinical samples10.1038/s41598-020-79552-z2045-2322https://doaj.org/article/ad2cd95d5924471fa2c8522a8e1923622021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79552-zhttps://doaj.org/toc/2045-2322Abstract SARS-CoV-2 induces a muted innate immune response compared to other respiratory viruses. Mitochondrial dynamics might partially mediate this effect of SARS-CoV-2 on innate immunity. Polypeptides encoded by open reading frames of SARS-CoV and SARS-CoV-2 have been shown to localize to mitochondria and disrupt Mitochondrial Antiviral Signaling (MAVS) protein signaling. Therefore, we hypothesized that SARS-CoV-2 would distinctly regulate the mitochondrial transcriptome. We analyzed multiple publicly available RNASeq data derived from primary cells, cell lines, and clinical samples (i.e., BALF and lung). We report that SARS-CoV-2 did not dramatically regulate (1) mtDNA-encoded gene expression or (2) MAVS expression, and (3) SARS-CoV-2 downregulated nuclear-encoded mitochondrial (NEM) genes related to cellular respiration and Complex I.Brendan MillerAna SilversteinMelanie FloresKevin CaoHiroshi KumagaiHemal H. MehtaKelvin YenSu- Jeong KimPinchas CohenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Brendan Miller Ana Silverstein Melanie Flores Kevin Cao Hiroshi Kumagai Hemal H. Mehta Kelvin Yen Su- Jeong Kim Pinchas Cohen Host mitochondrial transcriptome response to SARS-CoV-2 in multiple cell models and clinical samples
description	Abstract SARS-CoV-2 induces a muted innate immune response compared to other respiratory viruses. Mitochondrial dynamics might partially mediate this effect of SARS-CoV-2 on innate immunity. Polypeptides encoded by open reading frames of SARS-CoV and SARS-CoV-2 have been shown to localize to mitochondria and disrupt Mitochondrial Antiviral Signaling (MAVS) protein signaling. Therefore, we hypothesized that SARS-CoV-2 would distinctly regulate the mitochondrial transcriptome. We analyzed multiple publicly available RNASeq data derived from primary cells, cell lines, and clinical samples (i.e., BALF and lung). We report that SARS-CoV-2 did not dramatically regulate (1) mtDNA-encoded gene expression or (2) MAVS expression, and (3) SARS-CoV-2 downregulated nuclear-encoded mitochondrial (NEM) genes related to cellular respiration and Complex I.
format	article
author	Brendan Miller Ana Silverstein Melanie Flores Kevin Cao Hiroshi Kumagai Hemal H. Mehta Kelvin Yen Su- Jeong Kim Pinchas Cohen
author_facet	Brendan Miller Ana Silverstein Melanie Flores Kevin Cao Hiroshi Kumagai Hemal H. Mehta Kelvin Yen Su- Jeong Kim Pinchas Cohen
author_sort	Brendan Miller
title	Host mitochondrial transcriptome response to SARS-CoV-2 in multiple cell models and clinical samples
title_short	Host mitochondrial transcriptome response to SARS-CoV-2 in multiple cell models and clinical samples
title_full	Host mitochondrial transcriptome response to SARS-CoV-2 in multiple cell models and clinical samples
title_fullStr	Host mitochondrial transcriptome response to SARS-CoV-2 in multiple cell models and clinical samples
title_full_unstemmed	Host mitochondrial transcriptome response to SARS-CoV-2 in multiple cell models and clinical samples
title_sort	host mitochondrial transcriptome response to sars-cov-2 in multiple cell models and clinical samples
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ad2cd95d5924471fa2c8522a8e192362
work_keys_str_mv	AT brendanmiller hostmitochondrialtranscriptomeresponsetosarscov2inmultiplecellmodelsandclinicalsamples AT anasilverstein hostmitochondrialtranscriptomeresponsetosarscov2inmultiplecellmodelsandclinicalsamples AT melanieflores hostmitochondrialtranscriptomeresponsetosarscov2inmultiplecellmodelsandclinicalsamples AT kevincao hostmitochondrialtranscriptomeresponsetosarscov2inmultiplecellmodelsandclinicalsamples AT hiroshikumagai hostmitochondrialtranscriptomeresponsetosarscov2inmultiplecellmodelsandclinicalsamples AT hemalhmehta hostmitochondrialtranscriptomeresponsetosarscov2inmultiplecellmodelsandclinicalsamples AT kelvinyen hostmitochondrialtranscriptomeresponsetosarscov2inmultiplecellmodelsandclinicalsamples AT sujeongkim hostmitochondrialtranscriptomeresponsetosarscov2inmultiplecellmodelsandclinicalsamples AT pinchascohen hostmitochondrialtranscriptomeresponsetosarscov2inmultiplecellmodelsandclinicalsamples
_version_	1718395246046347264

Host mitochondrial transcriptome response to SARS-CoV-2 in multiple cell models and clinical samples

Ejemplares similares