A standardized gnotobiotic mouse model harboring a minimal 15-member mouse gut microbiota recapitulates SOPF/SPF phenotypes

A standardized gnotobiotic mouse model harboring a minimal 15-member mouse gut microbiota recapitulates SOPF/SPF phenotypes

Here, the authors develop and characterize a mouse microbiota composed of 15 strains representative of the intestinal microbiota found in C57BL/6J specific opportunistic- and pathogen-free (C57Bl/6J SOPF) mice and derive a new standardized gnotobiotic mouse model, called GM15, which recapitulates th...

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Autores principales: Marion Darnaud, Filipe De Vadder, Pascaline Bogeat, Lilia Boucinha, Anne-Laure Bulteau, Andrei Bunescu, Céline Couturier, Ana Delgado, Hélène Dugua, Céline Elie, Alban Mathieu, Tereza Novotná, Djomangan Adama Ouattara, Séverine Planel, Adrien Saliou, Dagmar Šrůtková, Jennifer Yansouni, Bärbel Stecher, Martin Schwarzer, François Leulier, Andrea Tamellini
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/ad2f54703d4e4a40b40755a7d77374ec
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spelling oai:doaj.org-article:ad2f54703d4e4a40b40755a7d77374ec2021-11-21T12:34:12ZA standardized gnotobiotic mouse model harboring a minimal 15-member mouse gut microbiota recapitulates SOPF/SPF phenotypes10.1038/s41467-021-26963-92041-1723https://doaj.org/article/ad2f54703d4e4a40b40755a7d77374ec2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26963-9https://doaj.org/toc/2041-1723Here, the authors develop and characterize a mouse microbiota composed of 15 strains representative of the intestinal microbiota found in C57BL/6J specific opportunistic- and pathogen-free (C57Bl/6J SOPF) mice and derive a new standardized gnotobiotic mouse model, called GM15, which recapitulates the phenotypes of SOPF or SPF animals in different animal facilities with improved reproducibility.Marion DarnaudFilipe De VadderPascaline BogeatLilia BoucinhaAnne-Laure BulteauAndrei BunescuCéline CouturierAna DelgadoHélène DuguaCéline ElieAlban MathieuTereza NovotnáDjomangan Adama OuattaraSéverine PlanelAdrien SaliouDagmar ŠrůtkováJennifer YansouniBärbel StecherMartin SchwarzerFrançois LeulierAndrea TamelliniNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Marion Darnaud
Filipe De Vadder
Pascaline Bogeat
Lilia Boucinha
Anne-Laure Bulteau
Andrei Bunescu
Céline Couturier
Ana Delgado
Hélène Dugua
Céline Elie
Alban Mathieu
Tereza Novotná
Djomangan Adama Ouattara
Séverine Planel
Adrien Saliou
Dagmar Šrůtková
Jennifer Yansouni
Bärbel Stecher
Martin Schwarzer
François Leulier
Andrea Tamellini
A standardized gnotobiotic mouse model harboring a minimal 15-member mouse gut microbiota recapitulates SOPF/SPF phenotypes
description Here, the authors develop and characterize a mouse microbiota composed of 15 strains representative of the intestinal microbiota found in C57BL/6J specific opportunistic- and pathogen-free (C57Bl/6J SOPF) mice and derive a new standardized gnotobiotic mouse model, called GM15, which recapitulates the phenotypes of SOPF or SPF animals in different animal facilities with improved reproducibility.
format article
author Marion Darnaud
Filipe De Vadder
Pascaline Bogeat
Lilia Boucinha
Anne-Laure Bulteau
Andrei Bunescu
Céline Couturier
Ana Delgado
Hélène Dugua
Céline Elie
Alban Mathieu
Tereza Novotná
Djomangan Adama Ouattara
Séverine Planel
Adrien Saliou
Dagmar Šrůtková
Jennifer Yansouni
Bärbel Stecher
Martin Schwarzer
François Leulier
Andrea Tamellini
author_facet Marion Darnaud
Filipe De Vadder
Pascaline Bogeat
Lilia Boucinha
Anne-Laure Bulteau
Andrei Bunescu
Céline Couturier
Ana Delgado
Hélène Dugua
Céline Elie
Alban Mathieu
Tereza Novotná
Djomangan Adama Ouattara
Séverine Planel
Adrien Saliou
Dagmar Šrůtková
Jennifer Yansouni
Bärbel Stecher
Martin Schwarzer
François Leulier
Andrea Tamellini
author_sort Marion Darnaud
title A standardized gnotobiotic mouse model harboring a minimal 15-member mouse gut microbiota recapitulates SOPF/SPF phenotypes
title_short A standardized gnotobiotic mouse model harboring a minimal 15-member mouse gut microbiota recapitulates SOPF/SPF phenotypes
title_full A standardized gnotobiotic mouse model harboring a minimal 15-member mouse gut microbiota recapitulates SOPF/SPF phenotypes
title_fullStr A standardized gnotobiotic mouse model harboring a minimal 15-member mouse gut microbiota recapitulates SOPF/SPF phenotypes
title_full_unstemmed A standardized gnotobiotic mouse model harboring a minimal 15-member mouse gut microbiota recapitulates SOPF/SPF phenotypes
title_sort standardized gnotobiotic mouse model harboring a minimal 15-member mouse gut microbiota recapitulates sopf/spf phenotypes
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/ad2f54703d4e4a40b40755a7d77374ec
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