Region-Specific Biomarkers and Their Mechanisms in the Treatment of Lung Adenocarcinoma: A Study of Panax quinquefolius from Wendeng, China

Panax quinquefolius, a popular medicinal herb, has been cultivated in China for many years. In this work, the region-specific profiles of metabolites in P. quinquefolius from Wendeng was investigated using liquid-chromatography–quadrupole–time-of-flight-(LC–Q–TO...

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Autores principales:	Xuanming Zhang, Liwen Han, Peihai Li, Shanshan Zhang, Mengqi Zhang, Xiaobin Li, Jie Chu, Lizhen Wang, Pengfei Tu, Yun Zhang, Kechun Liu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Panax quinquefolius</i> biomarkers network pharmacology molecular docking protein phosphorylation Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/ad2ff22ac56342d89a0d759f849c1179
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spelling	oai:doaj.org-article:ad2ff22ac56342d89a0d759f849c11792021-11-25T18:27:34ZRegion-Specific Biomarkers and Their Mechanisms in the Treatment of Lung Adenocarcinoma: A Study of <i>Panax quinquefolius</i> from Wendeng, China10.3390/molecules262268291420-3049https://doaj.org/article/ad2ff22ac56342d89a0d759f849c11792021-11-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/22/6829https://doaj.org/toc/1420-3049<i>Panax quinquefolius</i>, a popular medicinal herb, has been cultivated in China for many years. In this work, the region-specific profiles of metabolites in <i>P. quinquefolius</i> from Wendeng was investigated using liquid-chromatography–quadrupole–time-of-flight-(LC–Q–TOF)-based metabolomics analysis. The three most abundant biomarkers, identified as ginsenoside Rb<sub>3</sub>, notoginsenoside R<sub>1</sub>, and ginsenoside Rc, were the representative chemical components employed in the network pharmacology analysis. In addition, molecular docking and western blotting analyses revealed that the three compounds were effective binding ligands with Hsp90α, resulting in the inactivation of SRC and PI3K kinase, which eventually led to the inactivation of the Akt and ERK pathways and lung cancer suppression. The outcomes obtained herein demonstrated the intriguing chemical characteristics and potential functional activities of <i>P. quinquefolius</i> from Wendeng.Xuanming ZhangLiwen HanPeihai LiShanshan ZhangMengqi ZhangXiaobin LiJie ChuLizhen WangPengfei TuYun ZhangKechun LiuMDPI AGarticle<i>Panax quinquefolius</i>biomarkersnetwork pharmacologymolecular dockingprotein phosphorylationOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6829, p 6829 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Panax quinquefolius</i> biomarkers network pharmacology molecular docking protein phosphorylation Organic chemistry QD241-441
spellingShingle	<i>Panax quinquefolius</i> biomarkers network pharmacology molecular docking protein phosphorylation Organic chemistry QD241-441 Xuanming Zhang Liwen Han Peihai Li Shanshan Zhang Mengqi Zhang Xiaobin Li Jie Chu Lizhen Wang Pengfei Tu Yun Zhang Kechun Liu Region-Specific Biomarkers and Their Mechanisms in the Treatment of Lung Adenocarcinoma: A Study of <i>Panax quinquefolius</i> from Wendeng, China
description	<i>Panax quinquefolius</i>, a popular medicinal herb, has been cultivated in China for many years. In this work, the region-specific profiles of metabolites in <i>P. quinquefolius</i> from Wendeng was investigated using liquid-chromatography–quadrupole–time-of-flight-(LC–Q–TOF)-based metabolomics analysis. The three most abundant biomarkers, identified as ginsenoside Rb<sub>3</sub>, notoginsenoside R<sub>1</sub>, and ginsenoside Rc, were the representative chemical components employed in the network pharmacology analysis. In addition, molecular docking and western blotting analyses revealed that the three compounds were effective binding ligands with Hsp90α, resulting in the inactivation of SRC and PI3K kinase, which eventually led to the inactivation of the Akt and ERK pathways and lung cancer suppression. The outcomes obtained herein demonstrated the intriguing chemical characteristics and potential functional activities of <i>P. quinquefolius</i> from Wendeng.
format	article
author	Xuanming Zhang Liwen Han Peihai Li Shanshan Zhang Mengqi Zhang Xiaobin Li Jie Chu Lizhen Wang Pengfei Tu Yun Zhang Kechun Liu
author_facet	Xuanming Zhang Liwen Han Peihai Li Shanshan Zhang Mengqi Zhang Xiaobin Li Jie Chu Lizhen Wang Pengfei Tu Yun Zhang Kechun Liu
author_sort	Xuanming Zhang
title	Region-Specific Biomarkers and Their Mechanisms in the Treatment of Lung Adenocarcinoma: A Study of <i>Panax quinquefolius</i> from Wendeng, China
title_short	Region-Specific Biomarkers and Their Mechanisms in the Treatment of Lung Adenocarcinoma: A Study of <i>Panax quinquefolius</i> from Wendeng, China
title_full	Region-Specific Biomarkers and Their Mechanisms in the Treatment of Lung Adenocarcinoma: A Study of <i>Panax quinquefolius</i> from Wendeng, China
title_fullStr	Region-Specific Biomarkers and Their Mechanisms in the Treatment of Lung Adenocarcinoma: A Study of <i>Panax quinquefolius</i> from Wendeng, China
title_full_unstemmed	Region-Specific Biomarkers and Their Mechanisms in the Treatment of Lung Adenocarcinoma: A Study of <i>Panax quinquefolius</i> from Wendeng, China
title_sort	region-specific biomarkers and their mechanisms in the treatment of lung adenocarcinoma: a study of <i>panax quinquefolius</i> from wendeng, china
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ad2ff22ac56342d89a0d759f849c1179
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Region-Specific Biomarkers and Their Mechanisms in the Treatment of Lung Adenocarcinoma: A Study of <i>Panax quinquefolius</i> from Wendeng, China

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