High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program
Prostate cancer progression may be enhanced by a high-fat diet. Here the authors show that a diet high in saturated fats enhance the MYC-driven transcriptional program, a feature that independently predicts prostate cancer progression and death.
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Nature Portfolio
2019
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oai:doaj.org-article:ad31beb7d54c47838760eb7ff3f13cf92021-12-02T14:35:43ZHigh-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program10.1038/s41467-019-12298-z2041-1723https://doaj.org/article/ad31beb7d54c47838760eb7ff3f13cf92019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12298-zhttps://doaj.org/toc/2041-1723Prostate cancer progression may be enhanced by a high-fat diet. Here the authors show that a diet high in saturated fats enhance the MYC-driven transcriptional program, a feature that independently predicts prostate cancer progression and death.David P. LabbéGiorgia ZadraMeng YangJaime M. ReyesCharles Y. LinStefano CacciatoreEricka M. EbotAmanda L. CreechFrancesca GiunchiMichelangelo FiorentinoHabiba ElfandySudeepa SyamalaEdward D. KarolyMohammed AlshalalfaNicholas ErhoAshley RossEdward M. SchaefferEwan A. GibbMandeep TakharRobert B. DenJonathan LehrerR. Jeffrey KarnesStephen J. FreedlandElai DavicioniDaniel E. SprattLeigh EllisJacob D. JaffeAnthony V. DʼAmicoPhilip W. KantoffJames E. BradnerLorelei A. MucciJorge E. ChavarroMassimo LodaMyles BrownNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q David P. Labbé Giorgia Zadra Meng Yang Jaime M. Reyes Charles Y. Lin Stefano Cacciatore Ericka M. Ebot Amanda L. Creech Francesca Giunchi Michelangelo Fiorentino Habiba Elfandy Sudeepa Syamala Edward D. Karoly Mohammed Alshalalfa Nicholas Erho Ashley Ross Edward M. Schaeffer Ewan A. Gibb Mandeep Takhar Robert B. Den Jonathan Lehrer R. Jeffrey Karnes Stephen J. Freedland Elai Davicioni Daniel E. Spratt Leigh Ellis Jacob D. Jaffe Anthony V. DʼAmico Philip W. Kantoff James E. Bradner Lorelei A. Mucci Jorge E. Chavarro Massimo Loda Myles Brown High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program |
| description |
Prostate cancer progression may be enhanced by a high-fat diet. Here the authors show that a diet high in saturated fats enhance the MYC-driven transcriptional program, a feature that independently predicts prostate cancer progression and death. |
| format |
article |
| author |
David P. Labbé Giorgia Zadra Meng Yang Jaime M. Reyes Charles Y. Lin Stefano Cacciatore Ericka M. Ebot Amanda L. Creech Francesca Giunchi Michelangelo Fiorentino Habiba Elfandy Sudeepa Syamala Edward D. Karoly Mohammed Alshalalfa Nicholas Erho Ashley Ross Edward M. Schaeffer Ewan A. Gibb Mandeep Takhar Robert B. Den Jonathan Lehrer R. Jeffrey Karnes Stephen J. Freedland Elai Davicioni Daniel E. Spratt Leigh Ellis Jacob D. Jaffe Anthony V. DʼAmico Philip W. Kantoff James E. Bradner Lorelei A. Mucci Jorge E. Chavarro Massimo Loda Myles Brown |
| author_facet |
David P. Labbé Giorgia Zadra Meng Yang Jaime M. Reyes Charles Y. Lin Stefano Cacciatore Ericka M. Ebot Amanda L. Creech Francesca Giunchi Michelangelo Fiorentino Habiba Elfandy Sudeepa Syamala Edward D. Karoly Mohammed Alshalalfa Nicholas Erho Ashley Ross Edward M. Schaeffer Ewan A. Gibb Mandeep Takhar Robert B. Den Jonathan Lehrer R. Jeffrey Karnes Stephen J. Freedland Elai Davicioni Daniel E. Spratt Leigh Ellis Jacob D. Jaffe Anthony V. DʼAmico Philip W. Kantoff James E. Bradner Lorelei A. Mucci Jorge E. Chavarro Massimo Loda Myles Brown |
| author_sort |
David P. Labbé |
| title |
High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program |
| title_short |
High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program |
| title_full |
High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program |
| title_fullStr |
High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program |
| title_full_unstemmed |
High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program |
| title_sort |
high-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the myc program |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/ad31beb7d54c47838760eb7ff3f13cf9 |
| work_keys_str_mv |
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