Global kinome profiling reveals DYRK1A as critical activator of the human mitochondrial import machinery

Global kinome profiling reveals DYRK1A as critical activator of the human mitochondrial import machinery

Mitochondrial protein import is mediated by the translocase of the outer membrane (TOM), through which nearly all precursors traverse. Here, the authors perform global in vitro kinome profiling and by this identify that DYRK1A phosphorylates TOM70 and promotes import.

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Autores principales: Corvin Walter, Adinarayana Marada, Tamara Suhm, Ralf Ernsberger, Vera Muders, Cansu Kücükköse, Pablo Sánchez-Martín, Zehan Hu, Abhishek Aich, Stefan Loroch, Fiorella Andrea Solari, Daniel Poveda-Huertes, Alexandra Schwierzok, Henrike Pommerening, Stanka Matic, Jan Brix, Albert Sickmann, Claudine Kraft, Jörn Dengjel, Sven Dennerlein, Tilman Brummer, F.-Nora Vögtle, Chris Meisinger
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Q
Acceso en línea:https://doaj.org/article/ad335a0ad991411586d01fad9f3c40e2
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spelling oai:doaj.org-article:ad335a0ad991411586d01fad9f3c40e22021-12-02T18:31:30ZGlobal kinome profiling reveals DYRK1A as critical activator of the human mitochondrial import machinery10.1038/s41467-021-24426-92041-1723https://doaj.org/article/ad335a0ad991411586d01fad9f3c40e22021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24426-9https://doaj.org/toc/2041-1723Mitochondrial protein import is mediated by the translocase of the outer membrane (TOM), through which nearly all precursors traverse. Here, the authors perform global in vitro kinome profiling and by this identify that DYRK1A phosphorylates TOM70 and promotes import.Corvin WalterAdinarayana MaradaTamara SuhmRalf ErnsbergerVera MudersCansu KücükkösePablo Sánchez-MartínZehan HuAbhishek AichStefan LorochFiorella Andrea SolariDaniel Poveda-HuertesAlexandra SchwierzokHenrike PommereningStanka MaticJan BrixAlbert SickmannClaudine KraftJörn DengjelSven DennerleinTilman BrummerF.-Nora VögtleChris MeisingerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Corvin Walter
Adinarayana Marada
Tamara Suhm
Ralf Ernsberger
Vera Muders
Cansu Kücükköse
Pablo Sánchez-Martín
Zehan Hu
Abhishek Aich
Stefan Loroch
Fiorella Andrea Solari
Daniel Poveda-Huertes
Alexandra Schwierzok
Henrike Pommerening
Stanka Matic
Jan Brix
Albert Sickmann
Claudine Kraft
Jörn Dengjel
Sven Dennerlein
Tilman Brummer
F.-Nora Vögtle
Chris Meisinger
Global kinome profiling reveals DYRK1A as critical activator of the human mitochondrial import machinery
description Mitochondrial protein import is mediated by the translocase of the outer membrane (TOM), through which nearly all precursors traverse. Here, the authors perform global in vitro kinome profiling and by this identify that DYRK1A phosphorylates TOM70 and promotes import.
format article
author Corvin Walter
Adinarayana Marada
Tamara Suhm
Ralf Ernsberger
Vera Muders
Cansu Kücükköse
Pablo Sánchez-Martín
Zehan Hu
Abhishek Aich
Stefan Loroch
Fiorella Andrea Solari
Daniel Poveda-Huertes
Alexandra Schwierzok
Henrike Pommerening
Stanka Matic
Jan Brix
Albert Sickmann
Claudine Kraft
Jörn Dengjel
Sven Dennerlein
Tilman Brummer
F.-Nora Vögtle
Chris Meisinger
author_facet Corvin Walter
Adinarayana Marada
Tamara Suhm
Ralf Ernsberger
Vera Muders
Cansu Kücükköse
Pablo Sánchez-Martín
Zehan Hu
Abhishek Aich
Stefan Loroch
Fiorella Andrea Solari
Daniel Poveda-Huertes
Alexandra Schwierzok
Henrike Pommerening
Stanka Matic
Jan Brix
Albert Sickmann
Claudine Kraft
Jörn Dengjel
Sven Dennerlein
Tilman Brummer
F.-Nora Vögtle
Chris Meisinger
author_sort Corvin Walter
title Global kinome profiling reveals DYRK1A as critical activator of the human mitochondrial import machinery
title_short Global kinome profiling reveals DYRK1A as critical activator of the human mitochondrial import machinery
title_full Global kinome profiling reveals DYRK1A as critical activator of the human mitochondrial import machinery
title_fullStr Global kinome profiling reveals DYRK1A as critical activator of the human mitochondrial import machinery
title_full_unstemmed Global kinome profiling reveals DYRK1A as critical activator of the human mitochondrial import machinery
title_sort global kinome profiling reveals dyrk1a as critical activator of the human mitochondrial import machinery
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/ad335a0ad991411586d01fad9f3c40e2
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