Dairy Consumption, Lactase Persistence, and Mortality Risk in a Cohort From Southern Sweden

Background: Whether high dairy consumption is related to longevity is still unclear, and additional studies of prospective cohorts with high-quality dietary data from populations with wide consumption ranges are needed.Objective: To examine the association between dairy consumption and mortality in...

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Autores principales:	Emily Sonestedt, Yan Borné, Elisabet Wirfält, Ulrika Ericson
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	dairy milk cheese butter mortality LCT-13910C/T polymorphism Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/ad350d4d4a2244fcb4be88a7e758052c
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spelling	oai:doaj.org-article:ad350d4d4a2244fcb4be88a7e758052c2021-11-30T18:12:20ZDairy Consumption, Lactase Persistence, and Mortality Risk in a Cohort From Southern Sweden2296-861X10.3389/fnut.2021.779034https://doaj.org/article/ad350d4d4a2244fcb4be88a7e758052c2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnut.2021.779034/fullhttps://doaj.org/toc/2296-861XBackground: Whether high dairy consumption is related to longevity is still unclear, and additional studies of prospective cohorts with high-quality dietary data from populations with wide consumption ranges are needed.Objective: To examine the association between dairy consumption and mortality in a Swedish cohort.Design: Among 26,190 participants (62% females, 45–73 years old) without diabetes and cardiovascular disease from the population-based Malmö Diet and Cancer cohort, 7,156 individuals died during a mean follow-up time of 19 years. Data on intake of dairy (non-fermented milk, fermented milk, cheese, cream and butter) were collected from 7 day food records and food questionnaires. A genetic marker (rs4988235) associated with lactase persistence was detected among 22,234 individuals born in Sweden.Results: Higher intakes up to 1,000 g/day of non-fermented milk were associated with only marginal higher mortality rates after adjusting for potential confounders. However, intakes above 1,000 g/day (1.5% of the population) were associated with 34% (95% CI: 14, 59%, p-trend=0.002) higher mortality compared to that with < 200 g/day. Fermented milk and cheese intake were inversely associated with mortality. Cream showed a protective association only among men. Butter was not associated with mortality. CT/TT genotype carriers (i.e., individuals with lactase persistence) had a 27% higher reported consumption of non-fermented milk, and non-significant higher mortality risk (HR = 1.08; 95% CI = 0.96, 1.23; p = 0.20) than CC genotype carriers.Conclusions: Higher mortality rates were mainly observed among participants consuming more than 1,000 g of non-fermented milk per day. In contrast, fermented milk and cheese were associated with lower mortality. Because dairy products differ in composition, it is important to examine them separately in their relation to health and disease. The use of a genetic variant as an objective marker of lactose-containing milk intake should be examined in relation to mortality in a larger population.Emily SonestedtYan BornéElisabet WirfältUlrika EricsonFrontiers Media S.A.articledairymilkcheesebuttermortalityLCT-13910C/T polymorphismNutrition. Foods and food supplyTX341-641ENFrontiers in Nutrition, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	dairy milk cheese butter mortality LCT-13910C/T polymorphism Nutrition. Foods and food supply TX341-641
spellingShingle	dairy milk cheese butter mortality LCT-13910C/T polymorphism Nutrition. Foods and food supply TX341-641 Emily Sonestedt Yan Borné Elisabet Wirfält Ulrika Ericson Dairy Consumption, Lactase Persistence, and Mortality Risk in a Cohort From Southern Sweden
description	Background: Whether high dairy consumption is related to longevity is still unclear, and additional studies of prospective cohorts with high-quality dietary data from populations with wide consumption ranges are needed.Objective: To examine the association between dairy consumption and mortality in a Swedish cohort.Design: Among 26,190 participants (62% females, 45–73 years old) without diabetes and cardiovascular disease from the population-based Malmö Diet and Cancer cohort, 7,156 individuals died during a mean follow-up time of 19 years. Data on intake of dairy (non-fermented milk, fermented milk, cheese, cream and butter) were collected from 7 day food records and food questionnaires. A genetic marker (rs4988235) associated with lactase persistence was detected among 22,234 individuals born in Sweden.Results: Higher intakes up to 1,000 g/day of non-fermented milk were associated with only marginal higher mortality rates after adjusting for potential confounders. However, intakes above 1,000 g/day (1.5% of the population) were associated with 34% (95% CI: 14, 59%, p-trend=0.002) higher mortality compared to that with < 200 g/day. Fermented milk and cheese intake were inversely associated with mortality. Cream showed a protective association only among men. Butter was not associated with mortality. CT/TT genotype carriers (i.e., individuals with lactase persistence) had a 27% higher reported consumption of non-fermented milk, and non-significant higher mortality risk (HR = 1.08; 95% CI = 0.96, 1.23; p = 0.20) than CC genotype carriers.Conclusions: Higher mortality rates were mainly observed among participants consuming more than 1,000 g of non-fermented milk per day. In contrast, fermented milk and cheese were associated with lower mortality. Because dairy products differ in composition, it is important to examine them separately in their relation to health and disease. The use of a genetic variant as an objective marker of lactose-containing milk intake should be examined in relation to mortality in a larger population.
format	article
author	Emily Sonestedt Yan Borné Elisabet Wirfält Ulrika Ericson
author_facet	Emily Sonestedt Yan Borné Elisabet Wirfält Ulrika Ericson
author_sort	Emily Sonestedt
title	Dairy Consumption, Lactase Persistence, and Mortality Risk in a Cohort From Southern Sweden
title_short	Dairy Consumption, Lactase Persistence, and Mortality Risk in a Cohort From Southern Sweden
title_full	Dairy Consumption, Lactase Persistence, and Mortality Risk in a Cohort From Southern Sweden
title_fullStr	Dairy Consumption, Lactase Persistence, and Mortality Risk in a Cohort From Southern Sweden
title_full_unstemmed	Dairy Consumption, Lactase Persistence, and Mortality Risk in a Cohort From Southern Sweden
title_sort	dairy consumption, lactase persistence, and mortality risk in a cohort from southern sweden
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/ad350d4d4a2244fcb4be88a7e758052c
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Dairy Consumption, Lactase Persistence, and Mortality Risk in a Cohort From Southern Sweden

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