Hyperuricemia as a Risk Factor for Cardiovascular Diseases

Serum uric acid level above 7 mg/dl is defined as hyperuricemia, which gives rise to the monosodium urate (MSU), causing gout and urolithiasis. Hyperuricemia is an independent risk factor as well as a marker for hypertension, heart failure, atherosclerosis, atrial fibrillation, and chronic kidney di...

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Autores principales:	Ichiro Hisatome, Peili Li, Fikri Taufiq, Nani Maharani, Masanari Kuwabara, Haruaki Ninomiya, Udin Bahrudin
Formato:	article
Lenguaje:	EN
Publicado:	Diponegoro University 2020
Materias:	hyperuricemia cardiovascular disease uric acid transporter xanthine oxidase inflammasome guideline Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/ad38a4b4ca0848da96e54b85fcf33d4e
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spelling	oai:doaj.org-article:ad38a4b4ca0848da96e54b85fcf33d4e2021-11-05T16:47:43ZHyperuricemia as a Risk Factor for Cardiovascular Diseases2503-217810.14710/jbtr.v6i3.9383https://doaj.org/article/ad38a4b4ca0848da96e54b85fcf33d4e2020-12-01T00:00:00Zhttps://ejournal2.undip.ac.id/index.php/jbtr/article/view/9383https://doaj.org/toc/2503-2178Serum uric acid level above 7 mg/dl is defined as hyperuricemia, which gives rise to the monosodium urate (MSU), causing gout and urolithiasis. Hyperuricemia is an independent risk factor as well as a marker for hypertension, heart failure, atherosclerosis, atrial fibrillation, and chronic kidney disease. MSU crystals, soluble uric acid (UA), or oxidative stress derived from xanthine oxidoreductase (XOR) might be plausible explanations for the association of cardio-renovascular diseases with hyperuricemia. In macrophages, MSU activates the Nod-like receptor family, pyrin　domain containing 3(NLRP3) inflammasome, and proteolytic processing mediated by caspase-1 with enhanced interleukin (IL)-1β and IL-18 secretion. Soluble UA accumulates intracellularly through UA transporters (UAT) in vascular and atrial myocytes, causing endothelial dysfunction ad atrial electrical remodeling. XOR generates reactive oxygen species (ROS) that lead to cardiovascular diseases. Since it remains unclear whether asymptomatic hyperuricemia could be a risk factor for cardiovascular and kidney diseases, European and American guidelines do not recommend pharmacological treatment for asymptomatic patients with cardio-renovascular diseases. The Japanese guideline, on the contrary, recommends pharmacological treatment for hyperuricemia with CKD to protect renal function, and it attaches importance of the cardio-renal interaction for the treatment of asymptomatic hyperuricemia patients with hypertension and heart failure.Ichiro HisatomePeili LiFikri TaufiqNani MaharaniMasanari KuwabaraHaruaki NinomiyaUdin BahrudinDiponegoro Universityarticlehyperuricemiacardiovascular diseaseuric acid transporterxanthine oxidaseinflammasomeguidelineMedicine (General)R5-920ENJournal of Biomedicine and Translational Research, Vol 6, Iss 3, Pp 101-109 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	hyperuricemia cardiovascular disease uric acid transporter xanthine oxidase inflammasome guideline Medicine (General) R5-920
spellingShingle	hyperuricemia cardiovascular disease uric acid transporter xanthine oxidase inflammasome guideline Medicine (General) R5-920 Ichiro Hisatome Peili Li Fikri Taufiq Nani Maharani Masanari Kuwabara Haruaki Ninomiya Udin Bahrudin Hyperuricemia as a Risk Factor for Cardiovascular Diseases
description	Serum uric acid level above 7 mg/dl is defined as hyperuricemia, which gives rise to the monosodium urate (MSU), causing gout and urolithiasis. Hyperuricemia is an independent risk factor as well as a marker for hypertension, heart failure, atherosclerosis, atrial fibrillation, and chronic kidney disease. MSU crystals, soluble uric acid (UA), or oxidative stress derived from xanthine oxidoreductase (XOR) might be plausible explanations for the association of cardio-renovascular diseases with hyperuricemia. In macrophages, MSU activates the Nod-like receptor family, pyrin　domain containing 3(NLRP3) inflammasome, and proteolytic processing mediated by caspase-1 with enhanced interleukin (IL)-1β and IL-18 secretion. Soluble UA accumulates intracellularly through UA transporters (UAT) in vascular and atrial myocytes, causing endothelial dysfunction ad atrial electrical remodeling. XOR generates reactive oxygen species (ROS) that lead to cardiovascular diseases. Since it remains unclear whether asymptomatic hyperuricemia could be a risk factor for cardiovascular and kidney diseases, European and American guidelines do not recommend pharmacological treatment for asymptomatic patients with cardio-renovascular diseases. The Japanese guideline, on the contrary, recommends pharmacological treatment for hyperuricemia with CKD to protect renal function, and it attaches importance of the cardio-renal interaction for the treatment of asymptomatic hyperuricemia patients with hypertension and heart failure.
format	article
author	Ichiro Hisatome Peili Li Fikri Taufiq Nani Maharani Masanari Kuwabara Haruaki Ninomiya Udin Bahrudin
author_facet	Ichiro Hisatome Peili Li Fikri Taufiq Nani Maharani Masanari Kuwabara Haruaki Ninomiya Udin Bahrudin
author_sort	Ichiro Hisatome
title	Hyperuricemia as a Risk Factor for Cardiovascular Diseases
title_short	Hyperuricemia as a Risk Factor for Cardiovascular Diseases
title_full	Hyperuricemia as a Risk Factor for Cardiovascular Diseases
title_fullStr	Hyperuricemia as a Risk Factor for Cardiovascular Diseases
title_full_unstemmed	Hyperuricemia as a Risk Factor for Cardiovascular Diseases
title_sort	hyperuricemia as a risk factor for cardiovascular diseases
publisher	Diponegoro University
publishDate	2020
url	https://doaj.org/article/ad38a4b4ca0848da96e54b85fcf33d4e
work_keys_str_mv	AT ichirohisatome hyperuricemiaasariskfactorforcardiovasculardiseases AT peilili hyperuricemiaasariskfactorforcardiovasculardiseases AT fikritaufiq hyperuricemiaasariskfactorforcardiovasculardiseases AT nanimaharani hyperuricemiaasariskfactorforcardiovasculardiseases AT masanarikuwabara hyperuricemiaasariskfactorforcardiovasculardiseases AT haruakininomiya hyperuricemiaasariskfactorforcardiovasculardiseases AT udinbahrudin hyperuricemiaasariskfactorforcardiovasculardiseases
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Hyperuricemia as a Risk Factor for Cardiovascular Diseases

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