A digital single-molecule nanopillar SERS platform for predicting and monitoring immune toxicities in immunotherapy

There is a clinical need to monitor immune-related toxicities of immune checkpoint blockade therapy. Here, the authors develop a digital SERS platform for multiplexed single cytokine counting to track immune-toxicities and demonstrate the ability to use pre-screening to identify patients at higher r...

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Autores principales: Junrong Li, Alain Wuethrich, Abu A. I. Sina, Han-Hao Cheng, Yuling Wang, Andreas Behren, Paul N. Mainwaring, Matt Trau
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/ad3a6c015bda45c3bc4d1c2fcc075fea
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Sumario:There is a clinical need to monitor immune-related toxicities of immune checkpoint blockade therapy. Here, the authors develop a digital SERS platform for multiplexed single cytokine counting to track immune-toxicities and demonstrate the ability to use pre-screening to identify patients at higher risk.