A digital single-molecule nanopillar SERS platform for predicting and monitoring immune toxicities in immunotherapy

A digital single-molecule nanopillar SERS platform for predicting and monitoring immune toxicities in immunotherapy

There is a clinical need to monitor immune-related toxicities of immune checkpoint blockade therapy. Here, the authors develop a digital SERS platform for multiplexed single cytokine counting to track immune-toxicities and demonstrate the ability to use pre-screening to identify patients at higher r...

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Autores principales: Junrong Li, Alain Wuethrich, Abu A. I. Sina, Han-Hao Cheng, Yuling Wang, Andreas Behren, Paul N. Mainwaring, Matt Trau
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/ad3a6c015bda45c3bc4d1c2fcc075fea
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spelling oai:doaj.org-article:ad3a6c015bda45c3bc4d1c2fcc075fea2021-12-02T10:52:30ZA digital single-molecule nanopillar SERS platform for predicting and monitoring immune toxicities in immunotherapy10.1038/s41467-021-21431-w2041-1723https://doaj.org/article/ad3a6c015bda45c3bc4d1c2fcc075fea2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21431-whttps://doaj.org/toc/2041-1723There is a clinical need to monitor immune-related toxicities of immune checkpoint blockade therapy. Here, the authors develop a digital SERS platform for multiplexed single cytokine counting to track immune-toxicities and demonstrate the ability to use pre-screening to identify patients at higher risk.Junrong LiAlain WuethrichAbu A. I. SinaHan-Hao ChengYuling WangAndreas BehrenPaul N. MainwaringMatt TrauNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Junrong Li
Alain Wuethrich
Abu A. I. Sina
Han-Hao Cheng
Yuling Wang
Andreas Behren
Paul N. Mainwaring
Matt Trau
A digital single-molecule nanopillar SERS platform for predicting and monitoring immune toxicities in immunotherapy
description There is a clinical need to monitor immune-related toxicities of immune checkpoint blockade therapy. Here, the authors develop a digital SERS platform for multiplexed single cytokine counting to track immune-toxicities and demonstrate the ability to use pre-screening to identify patients at higher risk.
format article
author Junrong Li
Alain Wuethrich
Abu A. I. Sina
Han-Hao Cheng
Yuling Wang
Andreas Behren
Paul N. Mainwaring
Matt Trau
author_facet Junrong Li
Alain Wuethrich
Abu A. I. Sina
Han-Hao Cheng
Yuling Wang
Andreas Behren
Paul N. Mainwaring
Matt Trau
author_sort Junrong Li
title A digital single-molecule nanopillar SERS platform for predicting and monitoring immune toxicities in immunotherapy
title_short A digital single-molecule nanopillar SERS platform for predicting and monitoring immune toxicities in immunotherapy
title_full A digital single-molecule nanopillar SERS platform for predicting and monitoring immune toxicities in immunotherapy
title_fullStr A digital single-molecule nanopillar SERS platform for predicting and monitoring immune toxicities in immunotherapy
title_full_unstemmed A digital single-molecule nanopillar SERS platform for predicting and monitoring immune toxicities in immunotherapy
title_sort digital single-molecule nanopillar sers platform for predicting and monitoring immune toxicities in immunotherapy
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/ad3a6c015bda45c3bc4d1c2fcc075fea
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