JUVENILE ARTHRITIS DISEASE ACTIVITY SCORE IN CHILDREN WITH JUVENILE IDIOPATHIC ARTHRITIS AND ITS ASSOCIATION WITH CLINICAL DISEASE ACTIVITY IN LAHORE

Objective: To determine Juvenile Arthritis Disease Activity Score in children with juvenile idiopathic arthritis and its association with disease activity. Study Design: Cross sectional analytical. Place and Duration of Study: The study was conducted in the department of Immunology & Serology...

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Autores principales:	Zanera Nawaz, Farhana Shahzad, Saba Aziz
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2018
Materias:	crp esr juvenile arthritis disease Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/ad3aa8eee46d4360a5365530f860a366
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spelling	oai:doaj.org-article:ad3aa8eee46d4360a5365530f860a3662021-12-02T06:29:29ZJUVENILE ARTHRITIS DISEASE ACTIVITY SCORE IN CHILDREN WITH JUVENILE IDIOPATHIC ARTHRITIS AND ITS ASSOCIATION WITH CLINICAL DISEASE ACTIVITY IN LAHORE0030-96482411-8842https://doaj.org/article/ad3aa8eee46d4360a5365530f860a3662018-10-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/2302/1997https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To determine Juvenile Arthritis Disease Activity Score in children with juvenile idiopathic arthritis and its association with disease activity. Study Design: Cross sectional analytical. Place and Duration of Study: The study was conducted in the department of Immunology & Serology, the Children Hospital and the Institute of Child Health Lahore, from Jun 2015 to Jun 2016. Material and Methods: All consecutive patients in a period of three months from Jun to Aug who fulfilled the inclusion criteria were enrolled from Out Patient Department and Medical Unit 1. Demographic profile including age and gender were recorded. Type of arthritis was assigned according to ILAR. The severity of the disease of patients was assessed by using the JADAS-27 score at the time of presentation. Statical analysis of data was done on SPSS version 17.0 for obtaining statistical results. Results: Out of 45 patients, 44% (n=20) were males and 56% (n=25) were females between the age of 3-17 years. polyarthritis was found in 51.1% (n=23) followed by oligoarthritis 37.7% (n=17) and systemic onset disease 11.1% (n=5). Morning stiffness (97.8%) and fever (86.7%) were the most common clinical presentations. All patients with systemic onset disease had fever (n=5) followed by skin rash, hepatosplenomegaly and lymphadenopathy. Creactive protein was positive in 30 (66.67%) patients. Erythrocyte sedimentation rate was raised in 41 (91.11%) patients. Rheumatoid factor (RF) positivity was observed in 12 (26.67%) cases. Anti-nuclear antibodies were found positive in 3 (6.66%) patients. Out of 45 patients 5 were in clinical remission, 11 were in minimal disease activity and 29 had severe clinical disease activity. Maximum 11 cases of severe disease activity lie between 30-40 JADAS-27 score each for CRP and ESR. Conclusion: There was significant association between Juvenile Arthritis Disease Activity Score and Clinical Disease Activity. CRP and ESR were proved to be good inflammatory markers in JIA.Zanera NawazFarhana ShahzadSaba AzizArmy Medical College Rawalpindiarticlecrpesrjuvenile arthritis diseaseMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 68, Iss 5, Pp 1249-1255 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	crp esr juvenile arthritis disease Medicine R Medicine (General) R5-920
spellingShingle	crp esr juvenile arthritis disease Medicine R Medicine (General) R5-920 Zanera Nawaz Farhana Shahzad Saba Aziz JUVENILE ARTHRITIS DISEASE ACTIVITY SCORE IN CHILDREN WITH JUVENILE IDIOPATHIC ARTHRITIS AND ITS ASSOCIATION WITH CLINICAL DISEASE ACTIVITY IN LAHORE
description	Objective: To determine Juvenile Arthritis Disease Activity Score in children with juvenile idiopathic arthritis and its association with disease activity. Study Design: Cross sectional analytical. Place and Duration of Study: The study was conducted in the department of Immunology & Serology, the Children Hospital and the Institute of Child Health Lahore, from Jun 2015 to Jun 2016. Material and Methods: All consecutive patients in a period of three months from Jun to Aug who fulfilled the inclusion criteria were enrolled from Out Patient Department and Medical Unit 1. Demographic profile including age and gender were recorded. Type of arthritis was assigned according to ILAR. The severity of the disease of patients was assessed by using the JADAS-27 score at the time of presentation. Statical analysis of data was done on SPSS version 17.0 for obtaining statistical results. Results: Out of 45 patients, 44% (n=20) were males and 56% (n=25) were females between the age of 3-17 years. polyarthritis was found in 51.1% (n=23) followed by oligoarthritis 37.7% (n=17) and systemic onset disease 11.1% (n=5). Morning stiffness (97.8%) and fever (86.7%) were the most common clinical presentations. All patients with systemic onset disease had fever (n=5) followed by skin rash, hepatosplenomegaly and lymphadenopathy. Creactive protein was positive in 30 (66.67%) patients. Erythrocyte sedimentation rate was raised in 41 (91.11%) patients. Rheumatoid factor (RF) positivity was observed in 12 (26.67%) cases. Anti-nuclear antibodies were found positive in 3 (6.66%) patients. Out of 45 patients 5 were in clinical remission, 11 were in minimal disease activity and 29 had severe clinical disease activity. Maximum 11 cases of severe disease activity lie between 30-40 JADAS-27 score each for CRP and ESR. Conclusion: There was significant association between Juvenile Arthritis Disease Activity Score and Clinical Disease Activity. CRP and ESR were proved to be good inflammatory markers in JIA.
format	article
author	Zanera Nawaz Farhana Shahzad Saba Aziz
author_facet	Zanera Nawaz Farhana Shahzad Saba Aziz
author_sort	Zanera Nawaz
title	JUVENILE ARTHRITIS DISEASE ACTIVITY SCORE IN CHILDREN WITH JUVENILE IDIOPATHIC ARTHRITIS AND ITS ASSOCIATION WITH CLINICAL DISEASE ACTIVITY IN LAHORE
title_short	JUVENILE ARTHRITIS DISEASE ACTIVITY SCORE IN CHILDREN WITH JUVENILE IDIOPATHIC ARTHRITIS AND ITS ASSOCIATION WITH CLINICAL DISEASE ACTIVITY IN LAHORE
title_full	JUVENILE ARTHRITIS DISEASE ACTIVITY SCORE IN CHILDREN WITH JUVENILE IDIOPATHIC ARTHRITIS AND ITS ASSOCIATION WITH CLINICAL DISEASE ACTIVITY IN LAHORE
title_fullStr	JUVENILE ARTHRITIS DISEASE ACTIVITY SCORE IN CHILDREN WITH JUVENILE IDIOPATHIC ARTHRITIS AND ITS ASSOCIATION WITH CLINICAL DISEASE ACTIVITY IN LAHORE
title_full_unstemmed	JUVENILE ARTHRITIS DISEASE ACTIVITY SCORE IN CHILDREN WITH JUVENILE IDIOPATHIC ARTHRITIS AND ITS ASSOCIATION WITH CLINICAL DISEASE ACTIVITY IN LAHORE
title_sort	juvenile arthritis disease activity score in children with juvenile idiopathic arthritis and its association with clinical disease activity in lahore
publisher	Army Medical College Rawalpindi
publishDate	2018
url	https://doaj.org/article/ad3aa8eee46d4360a5365530f860a366
work_keys_str_mv	AT zaneranawaz juvenilearthritisdiseaseactivityscoreinchildrenwithjuvenileidiopathicarthritisanditsassociationwithclinicaldiseaseactivityinlahore AT farhanashahzad juvenilearthritisdiseaseactivityscoreinchildrenwithjuvenileidiopathicarthritisanditsassociationwithclinicaldiseaseactivityinlahore AT sabaaziz juvenilearthritisdiseaseactivityscoreinchildrenwithjuvenileidiopathicarthritisanditsassociationwithclinicaldiseaseactivityinlahore
_version_	1718399894368026624

JUVENILE ARTHRITIS DISEASE ACTIVITY SCORE IN CHILDREN WITH JUVENILE IDIOPATHIC ARTHRITIS AND ITS ASSOCIATION WITH CLINICAL DISEASE ACTIVITY IN LAHORE

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