The pro-inflammatory signalling regulator Stat4 promotes vasculogenesis of great vessels derived from endothelial precursors

The pro-inflammatory signalling regulator Stat4 promotes vasculogenesis of great vessels derived from endothelial precursors

Stat4 is a transcription factor known to regulate pro-inflammatory signalling. Here, Menget al. show that Stat4 is not only regulating inflammation but it is also crucial for great vessels development and endothelial precursor proliferation in zebrafish, by inhibiting the expression of hdac3and coun...

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Autores principales: Zhao-Zheng Meng, Wei Liu, Yu Xia, Hui-Min Yin, Chi-Yuan Zhang, Dan Su, Li-Feng Yan, Ai-Hua Gu, Yong Zhou
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/ad3f37f9c1604e628d62948defa0eef0
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spelling oai:doaj.org-article:ad3f37f9c1604e628d62948defa0eef02021-12-02T14:42:07ZThe pro-inflammatory signalling regulator Stat4 promotes vasculogenesis of great vessels derived from endothelial precursors10.1038/ncomms146402041-1723https://doaj.org/article/ad3f37f9c1604e628d62948defa0eef02017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14640https://doaj.org/toc/2041-1723Stat4 is a transcription factor known to regulate pro-inflammatory signalling. Here, Menget al. show that Stat4 is not only regulating inflammation but it is also crucial for great vessels development and endothelial precursor proliferation in zebrafish, by inhibiting the expression of hdac3and counteracting the effect of Stat1a.Zhao-Zheng MengWei LiuYu XiaHui-Min YinChi-Yuan ZhangDan SuLi-Feng YanAi-Hua GuYong ZhouNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Zhao-Zheng Meng
Wei Liu
Yu Xia
Hui-Min Yin
Chi-Yuan Zhang
Dan Su
Li-Feng Yan
Ai-Hua Gu
Yong Zhou
The pro-inflammatory signalling regulator Stat4 promotes vasculogenesis of great vessels derived from endothelial precursors
description Stat4 is a transcription factor known to regulate pro-inflammatory signalling. Here, Menget al. show that Stat4 is not only regulating inflammation but it is also crucial for great vessels development and endothelial precursor proliferation in zebrafish, by inhibiting the expression of hdac3and counteracting the effect of Stat1a.
format article
author Zhao-Zheng Meng
Wei Liu
Yu Xia
Hui-Min Yin
Chi-Yuan Zhang
Dan Su
Li-Feng Yan
Ai-Hua Gu
Yong Zhou
author_facet Zhao-Zheng Meng
Wei Liu
Yu Xia
Hui-Min Yin
Chi-Yuan Zhang
Dan Su
Li-Feng Yan
Ai-Hua Gu
Yong Zhou
author_sort Zhao-Zheng Meng
title The pro-inflammatory signalling regulator Stat4 promotes vasculogenesis of great vessels derived from endothelial precursors
title_short The pro-inflammatory signalling regulator Stat4 promotes vasculogenesis of great vessels derived from endothelial precursors
title_full The pro-inflammatory signalling regulator Stat4 promotes vasculogenesis of great vessels derived from endothelial precursors
title_fullStr The pro-inflammatory signalling regulator Stat4 promotes vasculogenesis of great vessels derived from endothelial precursors
title_full_unstemmed The pro-inflammatory signalling regulator Stat4 promotes vasculogenesis of great vessels derived from endothelial precursors
title_sort pro-inflammatory signalling regulator stat4 promotes vasculogenesis of great vessels derived from endothelial precursors
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/ad3f37f9c1604e628d62948defa0eef0
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