The metabolic signaling of the nucleoredoxin-like 2 gene supports brain function

The metabolic signaling of the nucleoredoxin-like 2 gene supports brain function

The nucleoredoxin gene NXNL2 encodes for two products through alternative splicing, rod-derived cone viability factor-2 (RdCVF2) that mediates neuronal survival and the thioredoxin-related protein (RdCVF2L), an enzyme that regulates the phosphorylation of TAU. To investigate the link between NXNL2 a...

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Bibliographic Details
Main Authors: Céline Jaillard, Farah Ouechtati, Emmanuelle Clérin, Géraldine Millet-Puel, Mariangela Corsi, Najate Aït-Ali, Frédéric Blond, Quentin Chevy, Lara Gales, Mélissa Farinelli, Deniz Dalkara, José-Alain Sahel, Jean-Charles Portais, Jean-Christophe Poncer, Thierry Léveillard
Format: article
Language:EN
Published: Elsevier 2021
Subjects:
Glucose metabolism
Thioredoxin
Tauopathy
Long-term potentiation
Metabolomics
Hippocampus
Medicine (General)
R5-920
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/ad3fc9da614f44d681064fa163f7b7dd
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