AdipoR agonist increases insulin sensitivity and exercise endurance in AdipoR-humanized mice

Masato Iwabu and Miki Okada-Iwabu et al. investigate whether diabetic phenotypes associated with disruption of the adiponectin receptor (AdipoR1) can be reversed in diabetic mice by upregulation of the receptor. They show that overexpressing human AdipoR1 in the muscles of diabetic mice increased in...

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Autores principales:	Masato Iwabu, Miki Okada-Iwabu, Hiroaki Tanabe, Nozomi Ohuchi, Keiko Miyata, Toshiko Kobori, Sara Odawara, Yuri Kadowaki, Shigeyuki Yokoyama, Toshimasa Yamauchi, Takashi Kadowaki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/ad41c15cf5f34d4ca0ec35d04c2cab1e
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spelling	oai:doaj.org-article:ad41c15cf5f34d4ca0ec35d04c2cab1e2021-12-02T15:13:13ZAdipoR agonist increases insulin sensitivity and exercise endurance in AdipoR-humanized mice10.1038/s42003-020-01579-92399-3642https://doaj.org/article/ad41c15cf5f34d4ca0ec35d04c2cab1e2021-01-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01579-9https://doaj.org/toc/2399-3642Masato Iwabu and Miki Okada-Iwabu et al. investigate whether diabetic phenotypes associated with disruption of the adiponectin receptor (AdipoR1) can be reversed in diabetic mice by upregulation of the receptor. They show that overexpressing human AdipoR1 in the muscles of diabetic mice increased insulin sensitivity and exercise endurance, suggesting a possible route for future clinical therapies.Masato IwabuMiki Okada-IwabuHiroaki TanabeNozomi OhuchiKeiko MiyataToshiko KoboriSara OdawaraYuri KadowakiShigeyuki YokoyamaToshimasa YamauchiTakashi KadowakiNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Masato Iwabu Miki Okada-Iwabu Hiroaki Tanabe Nozomi Ohuchi Keiko Miyata Toshiko Kobori Sara Odawara Yuri Kadowaki Shigeyuki Yokoyama Toshimasa Yamauchi Takashi Kadowaki AdipoR agonist increases insulin sensitivity and exercise endurance in AdipoR-humanized mice
description	Masato Iwabu and Miki Okada-Iwabu et al. investigate whether diabetic phenotypes associated with disruption of the adiponectin receptor (AdipoR1) can be reversed in diabetic mice by upregulation of the receptor. They show that overexpressing human AdipoR1 in the muscles of diabetic mice increased insulin sensitivity and exercise endurance, suggesting a possible route for future clinical therapies.
format	article
author	Masato Iwabu Miki Okada-Iwabu Hiroaki Tanabe Nozomi Ohuchi Keiko Miyata Toshiko Kobori Sara Odawara Yuri Kadowaki Shigeyuki Yokoyama Toshimasa Yamauchi Takashi Kadowaki
author_facet	Masato Iwabu Miki Okada-Iwabu Hiroaki Tanabe Nozomi Ohuchi Keiko Miyata Toshiko Kobori Sara Odawara Yuri Kadowaki Shigeyuki Yokoyama Toshimasa Yamauchi Takashi Kadowaki
author_sort	Masato Iwabu
title	AdipoR agonist increases insulin sensitivity and exercise endurance in AdipoR-humanized mice
title_short	AdipoR agonist increases insulin sensitivity and exercise endurance in AdipoR-humanized mice
title_full	AdipoR agonist increases insulin sensitivity and exercise endurance in AdipoR-humanized mice
title_fullStr	AdipoR agonist increases insulin sensitivity and exercise endurance in AdipoR-humanized mice
title_full_unstemmed	AdipoR agonist increases insulin sensitivity and exercise endurance in AdipoR-humanized mice
title_sort	adipor agonist increases insulin sensitivity and exercise endurance in adipor-humanized mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ad41c15cf5f34d4ca0ec35d04c2cab1e
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AdipoR agonist increases insulin sensitivity and exercise endurance in AdipoR-humanized mice

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