Fullerene-Filtered Light Spectrum and Fullerenes Modulate Emotional and Pain Processing in Mice

The most symmetric molecule, Buckminster fullerene C<sub>60</sub>, due to its unique properties, has been intensively studied for various medical and technological advances. Minimally invasive and minimally toxic treatments hold great promise for future applications. With this in mind, t...

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Autores principales:	Jelena Lazovic, Lydia M. Zopf, Jernej Hren, Martin Gajdoš, Marija Slavkovic, Zorana Jovic, Ivana Stankovic, Valentina Matovic, Djuro Koruga
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	fullerene fullerenol fullerenol water complex emotional processing anxiety light spectrum Mathematics QA1-939
Acceso en línea:	https://doaj.org/article/ad4411404b574977814c8c51de38b317
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spelling	oai:doaj.org-article:ad4411404b574977814c8c51de38b3172021-11-25T19:05:56ZFullerene-Filtered Light Spectrum and Fullerenes Modulate Emotional and Pain Processing in Mice10.3390/sym131120042073-8994https://doaj.org/article/ad4411404b574977814c8c51de38b3172021-10-01T00:00:00Zhttps://www.mdpi.com/2073-8994/13/11/2004https://doaj.org/toc/2073-8994The most symmetric molecule, Buckminster fullerene C<sub>60</sub>, due to its unique properties, has been intensively studied for various medical and technological advances. Minimally invasive and minimally toxic treatments hold great promise for future applications. With this in mind, this research exploited the physical properties of fullerene molecules for potential therapeutic effects. Pristine fullerenes have peak absorbance in the 380–500 nm range, making them an attractive violet-blue light filter. Since spectral quality of light can affect behavior, this research used resting state functional magnetic resonance imaging (rs fMRI) and behavioral testing to directly evaluate the effects of fullerene-filtered light on brain processing and behavior in mice. The same method was used to study if hydroxyl fullerene water complexes (3HFWC), with or without fullerene-filtered light, modulated brain processing. A month-long, daily exposure to fullerene-filtered light led to decreased activation of the brain area involved in emotional processing (amygdala). Water supplemented with 3HFWC resulted in an activation of brain areas involved in pain modulation and processing (periaqueductal gray), and decreased latency to first reaction when tested with a hot plate. The combination of fullerene-filtered light with 3HFWC in drinking water led to restored sensitivity to a hot plate and activation of brain areas involved in cognitive functions (prelimbic, anterior cingulate and retrosplenial cortex). These results uncovered the potential of fullerene-filtered light to impact emotional processing and modulate pain perception, indicating its further use in stress and pain management.Jelena LazovicLydia M. ZopfJernej HrenMartin GajdošMarija SlavkovicZorana JovicIvana StankovicValentina MatovicDjuro KorugaMDPI AGarticlefullerenefullerenolfullerenol water complexemotional processinganxietylight spectrumMathematicsQA1-939ENSymmetry, Vol 13, Iss 2004, p 2004 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	fullerene fullerenol fullerenol water complex emotional processing anxiety light spectrum Mathematics QA1-939
spellingShingle	fullerene fullerenol fullerenol water complex emotional processing anxiety light spectrum Mathematics QA1-939 Jelena Lazovic Lydia M. Zopf Jernej Hren Martin Gajdoš Marija Slavkovic Zorana Jovic Ivana Stankovic Valentina Matovic Djuro Koruga Fullerene-Filtered Light Spectrum and Fullerenes Modulate Emotional and Pain Processing in Mice
description	The most symmetric molecule, Buckminster fullerene C<sub>60</sub>, due to its unique properties, has been intensively studied for various medical and technological advances. Minimally invasive and minimally toxic treatments hold great promise for future applications. With this in mind, this research exploited the physical properties of fullerene molecules for potential therapeutic effects. Pristine fullerenes have peak absorbance in the 380–500 nm range, making them an attractive violet-blue light filter. Since spectral quality of light can affect behavior, this research used resting state functional magnetic resonance imaging (rs fMRI) and behavioral testing to directly evaluate the effects of fullerene-filtered light on brain processing and behavior in mice. The same method was used to study if hydroxyl fullerene water complexes (3HFWC), with or without fullerene-filtered light, modulated brain processing. A month-long, daily exposure to fullerene-filtered light led to decreased activation of the brain area involved in emotional processing (amygdala). Water supplemented with 3HFWC resulted in an activation of brain areas involved in pain modulation and processing (periaqueductal gray), and decreased latency to first reaction when tested with a hot plate. The combination of fullerene-filtered light with 3HFWC in drinking water led to restored sensitivity to a hot plate and activation of brain areas involved in cognitive functions (prelimbic, anterior cingulate and retrosplenial cortex). These results uncovered the potential of fullerene-filtered light to impact emotional processing and modulate pain perception, indicating its further use in stress and pain management.
format	article
author	Jelena Lazovic Lydia M. Zopf Jernej Hren Martin Gajdoš Marija Slavkovic Zorana Jovic Ivana Stankovic Valentina Matovic Djuro Koruga
author_facet	Jelena Lazovic Lydia M. Zopf Jernej Hren Martin Gajdoš Marija Slavkovic Zorana Jovic Ivana Stankovic Valentina Matovic Djuro Koruga
author_sort	Jelena Lazovic
title	Fullerene-Filtered Light Spectrum and Fullerenes Modulate Emotional and Pain Processing in Mice
title_short	Fullerene-Filtered Light Spectrum and Fullerenes Modulate Emotional and Pain Processing in Mice
title_full	Fullerene-Filtered Light Spectrum and Fullerenes Modulate Emotional and Pain Processing in Mice
title_fullStr	Fullerene-Filtered Light Spectrum and Fullerenes Modulate Emotional and Pain Processing in Mice
title_full_unstemmed	Fullerene-Filtered Light Spectrum and Fullerenes Modulate Emotional and Pain Processing in Mice
title_sort	fullerene-filtered light spectrum and fullerenes modulate emotional and pain processing in mice
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ad4411404b574977814c8c51de38b317
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Fullerene-Filtered Light Spectrum and Fullerenes Modulate Emotional and Pain Processing in Mice

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