Associations of Postoperative Complications Assessed by Clavien–Dindo Classification and Comprehensive Complication Index with Long-Term Overall Survival in Elderly Patients after Radical CRC Resection
Dong Wang,* Jinghui Zhang,* Zhigang Bai, Yingchi Yang, Tingting Wang, Lan Jin, Jin Wang, Guocong Wu, Tiankuo Kou, Zhongtao Zhang Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Cancer Invasion and Metastasis Research and National Clin...
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Dove Medical Press
2020
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oai:doaj.org-article:ad452b608a5c4820881dc1939fbe670c2021-12-02T12:22:51ZAssociations of Postoperative Complications Assessed by Clavien–Dindo Classification and Comprehensive Complication Index with Long-Term Overall Survival in Elderly Patients after Radical CRC Resection1178-1998https://doaj.org/article/ad452b608a5c4820881dc1939fbe670c2020-10-01T00:00:00Zhttps://www.dovepress.com/associations-of-postoperative-complications-assessed-by-clavienndashdi-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Dong Wang,* Jinghui Zhang,* Zhigang Bai, Yingchi Yang, Tingting Wang, Lan Jin, Jin Wang, Guocong Wu, Tiankuo Kou, Zhongtao Zhang Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Cancer Invasion and Metastasis Research and National Clinical Research Center of Digestive Diseases, Beijing 100050, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhongtao Zhang; Yingchi YangDepartment of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Cancer Invasion and Metastasis Research and National Clinical Research Center of Digestive Diseases, 95 Yongan Road, Xi-Cheng District, Beijing 100050, People’s Republic of ChinaTel +86-134-6668-0330; +86-158-1015-2032 Email zhangzht@ccmu.edu.cn; yangyingchi@ccmu.edu.cnBackground: Advancing age is associated with high incidence of colorectal cancer (CRC) and high rates of postoperative complications (POCs). However, the impact of of POC severity — evaluated by Clavien–Dindo classification (CDC) or comprehensive complication index (CCI) — on long-term overall survival (OS) in elderly patients after radical CRC resection is not clear.Methods: Elderly patients aged 65 years or more with CRC undergoing radical resection were retrospectively recruited. POC details were collected and evaluated using CDC grades and the CCI, blinded to patients’ other information. Risk factors for CDC grade ≥II POCs were analyzed by multivariate logistic regression. Effects of CDC grade II–IV POCs on long-term OS were analyzed via propensity-score matching (PSM) analysis followed by Kaplan–Meier curve plotting and multivariate Cox proportional-hazard regression adjusted for all potential confounders. The prognostic value of the CCI was also explored and compared with CDC grades.Results: A total of 614 elderly patients were identified, of which 20, 106, 25, 11, and 13 cases experienced CDC grade I, II, III, IV, and V POCs, respectively. Higher age, female sex, coronary heart diseases, family history of tumors, preoperative anemia, high amount of bleeding during operation, and high positive dissected lymph–node ratio were found to be risk factors for CDC grade II–V POCs. After PSM analyses, CDC grade II–IV POCs were identified to be associated with poor long-term OS, which was also verified in the entire cohort. The CCI was also found to be significantly associated with decreased long-term OS and showed prognostic values similar to CDC grades.Conclusion: Both CDC grades and the CCI can be used to evaluate POCs and are associated with long-term OS in elderly patients undergoing radical CRC resection.Keywords: elderly, colorectal cancer, postoperative complications, Clavien–Dindo classification, comprehensive complication index, overall survivalWang DZhang JBai ZYang YWang TJin LWang JWu GKou TZhang ZDove Medical Pressarticleelderlycolorectal cancerpostoperative complicationsclavien-dindo classificationcomprehensive complication indexoverall survivalGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 15, Pp 1939-1949 (2020) |
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DOAJ |
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DOAJ |
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EN |
| topic |
elderly colorectal cancer postoperative complications clavien-dindo classification comprehensive complication index overall survival Geriatrics RC952-954.6 |
| spellingShingle |
elderly colorectal cancer postoperative complications clavien-dindo classification comprehensive complication index overall survival Geriatrics RC952-954.6 Wang D Zhang J Bai Z Yang Y Wang T Jin L Wang J Wu G Kou T Zhang Z Associations of Postoperative Complications Assessed by Clavien–Dindo Classification and Comprehensive Complication Index with Long-Term Overall Survival in Elderly Patients after Radical CRC Resection |
| description |
Dong Wang,* Jinghui Zhang,* Zhigang Bai, Yingchi Yang, Tingting Wang, Lan Jin, Jin Wang, Guocong Wu, Tiankuo Kou, Zhongtao Zhang Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Cancer Invasion and Metastasis Research and National Clinical Research Center of Digestive Diseases, Beijing 100050, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhongtao Zhang; Yingchi YangDepartment of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Cancer Invasion and Metastasis Research and National Clinical Research Center of Digestive Diseases, 95 Yongan Road, Xi-Cheng District, Beijing 100050, People’s Republic of ChinaTel +86-134-6668-0330; +86-158-1015-2032 Email zhangzht@ccmu.edu.cn; yangyingchi@ccmu.edu.cnBackground: Advancing age is associated with high incidence of colorectal cancer (CRC) and high rates of postoperative complications (POCs). However, the impact of of POC severity — evaluated by Clavien–Dindo classification (CDC) or comprehensive complication index (CCI) — on long-term overall survival (OS) in elderly patients after radical CRC resection is not clear.Methods: Elderly patients aged 65 years or more with CRC undergoing radical resection were retrospectively recruited. POC details were collected and evaluated using CDC grades and the CCI, blinded to patients’ other information. Risk factors for CDC grade ≥II POCs were analyzed by multivariate logistic regression. Effects of CDC grade II–IV POCs on long-term OS were analyzed via propensity-score matching (PSM) analysis followed by Kaplan–Meier curve plotting and multivariate Cox proportional-hazard regression adjusted for all potential confounders. The prognostic value of the CCI was also explored and compared with CDC grades.Results: A total of 614 elderly patients were identified, of which 20, 106, 25, 11, and 13 cases experienced CDC grade I, II, III, IV, and V POCs, respectively. Higher age, female sex, coronary heart diseases, family history of tumors, preoperative anemia, high amount of bleeding during operation, and high positive dissected lymph–node ratio were found to be risk factors for CDC grade II–V POCs. After PSM analyses, CDC grade II–IV POCs were identified to be associated with poor long-term OS, which was also verified in the entire cohort. The CCI was also found to be significantly associated with decreased long-term OS and showed prognostic values similar to CDC grades.Conclusion: Both CDC grades and the CCI can be used to evaluate POCs and are associated with long-term OS in elderly patients undergoing radical CRC resection.Keywords: elderly, colorectal cancer, postoperative complications, Clavien–Dindo classification, comprehensive complication index, overall survival |
| format |
article |
| author |
Wang D Zhang J Bai Z Yang Y Wang T Jin L Wang J Wu G Kou T Zhang Z |
| author_facet |
Wang D Zhang J Bai Z Yang Y Wang T Jin L Wang J Wu G Kou T Zhang Z |
| author_sort |
Wang D |
| title |
Associations of Postoperative Complications Assessed by Clavien–Dindo Classification and Comprehensive Complication Index with Long-Term Overall Survival in Elderly Patients after Radical CRC Resection |
| title_short |
Associations of Postoperative Complications Assessed by Clavien–Dindo Classification and Comprehensive Complication Index with Long-Term Overall Survival in Elderly Patients after Radical CRC Resection |
| title_full |
Associations of Postoperative Complications Assessed by Clavien–Dindo Classification and Comprehensive Complication Index with Long-Term Overall Survival in Elderly Patients after Radical CRC Resection |
| title_fullStr |
Associations of Postoperative Complications Assessed by Clavien–Dindo Classification and Comprehensive Complication Index with Long-Term Overall Survival in Elderly Patients after Radical CRC Resection |
| title_full_unstemmed |
Associations of Postoperative Complications Assessed by Clavien–Dindo Classification and Comprehensive Complication Index with Long-Term Overall Survival in Elderly Patients after Radical CRC Resection |
| title_sort |
associations of postoperative complications assessed by clavien–dindo classification and comprehensive complication index with long-term overall survival in elderly patients after radical crc resection |
| publisher |
Dove Medical Press |
| publishDate |
2020 |
| url |
https://doaj.org/article/ad452b608a5c4820881dc1939fbe670c |
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