Structure of the exportin Xpo4 in complex with RanGTP and the hypusine-containing translation factor eIF5A

Xpo4 imports Sox2 and other proteins into the cell nucleus, while exporting eIF5A or Smad3; how it recognizes these proteins has been unclear. Here, the authors solved the crystal structure of the RanGTP, Xpo4 and eIF5A complex and investigate how Xpo4 identifies its major export cargo.

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Autores principales:	Metin Aksu, Sergei Trakhanov, Dirk Görlich
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ad45bd8ded734dd38c60e2c2891bb795
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spelling	oai:doaj.org-article:ad45bd8ded734dd38c60e2c2891bb7952021-12-02T15:35:41ZStructure of the exportin Xpo4 in complex with RanGTP and the hypusine-containing translation factor eIF5A10.1038/ncomms119522041-1723https://doaj.org/article/ad45bd8ded734dd38c60e2c2891bb7952016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11952https://doaj.org/toc/2041-1723Xpo4 imports Sox2 and other proteins into the cell nucleus, while exporting eIF5A or Smad3; how it recognizes these proteins has been unclear. Here, the authors solved the crystal structure of the RanGTP, Xpo4 and eIF5A complex and investigate how Xpo4 identifies its major export cargo.Metin AksuSergei TrakhanovDirk GörlichNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Metin Aksu Sergei Trakhanov Dirk Görlich Structure of the exportin Xpo4 in complex with RanGTP and the hypusine-containing translation factor eIF5A
description	Xpo4 imports Sox2 and other proteins into the cell nucleus, while exporting eIF5A or Smad3; how it recognizes these proteins has been unclear. Here, the authors solved the crystal structure of the RanGTP, Xpo4 and eIF5A complex and investigate how Xpo4 identifies its major export cargo.
format	article
author	Metin Aksu Sergei Trakhanov Dirk Görlich
author_facet	Metin Aksu Sergei Trakhanov Dirk Görlich
author_sort	Metin Aksu
title	Structure of the exportin Xpo4 in complex with RanGTP and the hypusine-containing translation factor eIF5A
title_short	Structure of the exportin Xpo4 in complex with RanGTP and the hypusine-containing translation factor eIF5A
title_full	Structure of the exportin Xpo4 in complex with RanGTP and the hypusine-containing translation factor eIF5A
title_fullStr	Structure of the exportin Xpo4 in complex with RanGTP and the hypusine-containing translation factor eIF5A
title_full_unstemmed	Structure of the exportin Xpo4 in complex with RanGTP and the hypusine-containing translation factor eIF5A
title_sort	structure of the exportin xpo4 in complex with rangtp and the hypusine-containing translation factor eif5a
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/ad45bd8ded734dd38c60e2c2891bb795
work_keys_str_mv	AT metinaksu structureoftheexportinxpo4incomplexwithrangtpandthehypusinecontainingtranslationfactoreif5a AT sergeitrakhanov structureoftheexportinxpo4incomplexwithrangtpandthehypusinecontainingtranslationfactoreif5a AT dirkgorlich structureoftheexportinxpo4incomplexwithrangtpandthehypusinecontainingtranslationfactoreif5a
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Structure of the exportin Xpo4 in complex with RanGTP and the hypusine-containing translation factor eIF5A

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