Comparison of Residual Depressive Symptoms, Functioning, and Quality of Life Between Patients with Recurrent Depression and First Episode Depression After Acute Treatment in China

Si Zu,1 Dong Wang,1 Jiexin Fang,1 Le Xiao,2 Xuequan Zhu,2 Wenyuan Wu,3 Gang Wang,2,4 Yongdong Hu1 1Department of Psychiatry, Beijing Chaoyang Hospital, Capital Medical University, Beijing, People’s Republic of China; 2The National Clinical Research Center for Mental Disorders & Beijing Key Labor...

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Autores principales:	Zu S, Wang D, Fang J, Xiao L, Zhu X, Wu W, Wang G, Hu Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	depression first-episode recurrent patient prognosis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/ad463978c1d94c60894ffe236a54f244
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id	oai:doaj.org-article:ad463978c1d94c60894ffe236a54f244
record_format	dspace
institution	DOAJ
collection	DOAJ
language	EN
topic	depression first-episode recurrent patient prognosis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	depression first-episode recurrent patient prognosis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Zu S Wang D Fang J Xiao L Zhu X Wu W Wang G Hu Y Comparison of Residual Depressive Symptoms, Functioning, and Quality of Life Between Patients with Recurrent Depression and First Episode Depression After Acute Treatment in China
description	Si Zu,1 Dong Wang,1 Jiexin Fang,1 Le Xiao,2 Xuequan Zhu,2 Wenyuan Wu,3 Gang Wang,2,4 Yongdong Hu1 1Department of Psychiatry, Beijing Chaoyang Hospital, Capital Medical University, Beijing, People’s Republic of China; 2The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, People’s Republic of China; 3Department of Psychiatry, Tongji Hospital of Tongji University, Shanghai, People’s Republic of China; 4Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, People’s Republic of ChinaCorrespondence: Gang WangThe National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, No. 5 Ankang Lane, Xicheng District, Beijing Anding Hospital, Beijing, 100088, People’s Republic of ChinaEmail gangwangdoc@ccmu.edu.cnYongdong HuDepartment of Psychiatry, Beijing Chaoyang Hospital, Capital Medical University, No. 8 Gongtinanlu, Chaoyang District, Beijing Chaoyang Hospital, Beijing, 100020, People’s Republic of ChinaTel +86-10-85231754Email haiyong.xie@ustc.eduObjective: This prospective study aimed to investigate the prognosis and rehabilitation of patients with recurrent depression and first episode depression after acute treatment in China.Methods: A total of 434 patients with first-episode or recurrent depression who received acute treatment respectively from sixteen hospitals in thirteen cities in China were enrolled in this prospective study. All patients were followed up for 6 months after acute treatment. The following data were collected at baseline period and 1, 3, and 6 months after acute treatment: general information of patients, medication information and patient’s condition changes, brief 16-item quick inventory of depressive symptomatology self-report (QIDS-SR16), patient health questionnaire-15 (PHQ-15), quality of life enjoyment and satisfaction questionnaire-short form (Q-LES-Q-SF), Sheehan disability scale (SDS) and digit symbol substitution test (DSST).Results: During the baseline period, there was a significant difference in QIDS-SR16 between recurrent patients and first-episode patients (p < 0.05), and there was no significant difference in other indicators (p > 0.05). At one month after acute treatment, there were significant differences in the total QIDS-SR16 score, the total Q-LES-SF score, the social life score, and the family life/home responsibilities score of SDS in patients with recurrent depression and first-episode depression (p < 0.05). At three months after acute treatment, there were significant differences in the total Q-LES-SF score and social life score of SDS in patients with recurrent depression and first-episode depression (p < 0.05). At six months after acute treatment, there were significant differences in the total QIDS-SR16 score, the social life score, and the total Q-LES-SF score in patients with recurrent depression and first-episode depression (p < 0.05). Compared with that data during the baseline period, the QIDS-SR16 scores and the SDS scores of all patients decreased, and the Q-LES-SF scores of all patients gradually increased as time went on during the consolidation period.Conclusion: The recurrent patients have more severe social function impairment, depressive symptoms, and lower life quality than that of the first-episode depressed patients. Given the negative impact of depressed symptom on recurrent patient, more attention should be paid to the treatment of recurrent patient and recurrence prevention of first episode patient.Keywords: depression, first-episode, recurrent patient, prognosis
format	article
author	Zu S Wang D Fang J Xiao L Zhu X Wu W Wang G Hu Y
author_facet	Zu S Wang D Fang J Xiao L Zhu X Wu W Wang G Hu Y
author_sort	Zu S
title	Comparison of Residual Depressive Symptoms, Functioning, and Quality of Life Between Patients with Recurrent Depression and First Episode Depression After Acute Treatment in China
title_short	Comparison of Residual Depressive Symptoms, Functioning, and Quality of Life Between Patients with Recurrent Depression and First Episode Depression After Acute Treatment in China
title_full	Comparison of Residual Depressive Symptoms, Functioning, and Quality of Life Between Patients with Recurrent Depression and First Episode Depression After Acute Treatment in China
title_fullStr	Comparison of Residual Depressive Symptoms, Functioning, and Quality of Life Between Patients with Recurrent Depression and First Episode Depression After Acute Treatment in China
title_full_unstemmed	Comparison of Residual Depressive Symptoms, Functioning, and Quality of Life Between Patients with Recurrent Depression and First Episode Depression After Acute Treatment in China
title_sort	comparison of residual depressive symptoms, functioning, and quality of life between patients with recurrent depression and first episode depression after acute treatment in china
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/ad463978c1d94c60894ffe236a54f244
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spelling	oai:doaj.org-article:ad463978c1d94c60894ffe236a54f2442021-12-02T19:16:13ZComparison of Residual Depressive Symptoms, Functioning, and Quality of Life Between Patients with Recurrent Depression and First Episode Depression After Acute Treatment in China1178-2021https://doaj.org/article/ad463978c1d94c60894ffe236a54f2442021-10-01T00:00:00Zhttps://www.dovepress.com/comparison-of-residual-depressive-symptoms-functioning-and-quality-of--peer-reviewed-fulltext-article-NDThttps://doaj.org/toc/1178-2021Si Zu,1 Dong Wang,1 Jiexin Fang,1 Le Xiao,2 Xuequan Zhu,2 Wenyuan Wu,3 Gang Wang,2,4 Yongdong Hu1 1Department of Psychiatry, Beijing Chaoyang Hospital, Capital Medical University, Beijing, People’s Republic of China; 2The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, People’s Republic of China; 3Department of Psychiatry, Tongji Hospital of Tongji University, Shanghai, People’s Republic of China; 4Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, People’s Republic of ChinaCorrespondence: Gang WangThe National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, No. 5 Ankang Lane, Xicheng District, Beijing Anding Hospital, Beijing, 100088, People’s Republic of ChinaEmail gangwangdoc@ccmu.edu.cnYongdong HuDepartment of Psychiatry, Beijing Chaoyang Hospital, Capital Medical University, No. 8 Gongtinanlu, Chaoyang District, Beijing Chaoyang Hospital, Beijing, 100020, People’s Republic of ChinaTel +86-10-85231754Email haiyong.xie@ustc.eduObjective: This prospective study aimed to investigate the prognosis and rehabilitation of patients with recurrent depression and first episode depression after acute treatment in China.Methods: A total of 434 patients with first-episode or recurrent depression who received acute treatment respectively from sixteen hospitals in thirteen cities in China were enrolled in this prospective study. All patients were followed up for 6 months after acute treatment. The following data were collected at baseline period and 1, 3, and 6 months after acute treatment: general information of patients, medication information and patient’s condition changes, brief 16-item quick inventory of depressive symptomatology self-report (QIDS-SR16), patient health questionnaire-15 (PHQ-15), quality of life enjoyment and satisfaction questionnaire-short form (Q-LES-Q-SF), Sheehan disability scale (SDS) and digit symbol substitution test (DSST).Results: During the baseline period, there was a significant difference in QIDS-SR16 between recurrent patients and first-episode patients (p < 0.05), and there was no significant difference in other indicators (p > 0.05). At one month after acute treatment, there were significant differences in the total QIDS-SR16 score, the total Q-LES-SF score, the social life score, and the family life/home responsibilities score of SDS in patients with recurrent depression and first-episode depression (p < 0.05). At three months after acute treatment, there were significant differences in the total Q-LES-SF score and social life score of SDS in patients with recurrent depression and first-episode depression (p < 0.05). At six months after acute treatment, there were significant differences in the total QIDS-SR16 score, the social life score, and the total Q-LES-SF score in patients with recurrent depression and first-episode depression (p < 0.05). Compared with that data during the baseline period, the QIDS-SR16 scores and the SDS scores of all patients decreased, and the Q-LES-SF scores of all patients gradually increased as time went on during the consolidation period.Conclusion: The recurrent patients have more severe social function impairment, depressive symptoms, and lower life quality than that of the first-episode depressed patients. Given the negative impact of depressed symptom on recurrent patient, more attention should be paid to the treatment of recurrent patient and recurrence prevention of first episode patient.Keywords: depression, first-episode, recurrent patient, prognosisZu SWang DFang JXiao LZhu XWu WWang GHu YDove Medical Pressarticledepressionfirst-episoderecurrent patientprognosisNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 17, Pp 3039-3051 (2021)

Comparison of Residual Depressive Symptoms, Functioning, and Quality of Life Between Patients with Recurrent Depression and First Episode Depression After Acute Treatment in China

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