Dissecting the sequence determinants for dephosphorylation by the catalytic subunits of phosphatases PP1 and PP2A

The substrate specificity of phosphoprotein phosphatases PP1 and PP2A depends on their catalytic and regulatory subunits. Using proteomics approaches, the authors here provide insights into the sequence specificity of the catalytic subunits and their distinct contributions to PP1 and PP2A selectivit...

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Autores principales:	Bernhard Hoermann, Thomas Kokot, Dominic Helm, Stephanie Heinzlmeir, Jeremy E. Chojnacki, Thomas Schubert, Christina Ludwig, Anna Berteotti, Nils Kurzawa, Bernhard Kuster, Mikhail M. Savitski, Maja Köhn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ad478d61be2b4e37af71927c9d84077e
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spelling	oai:doaj.org-article:ad478d61be2b4e37af71927c9d84077e2021-12-02T16:08:14ZDissecting the sequence determinants for dephosphorylation by the catalytic subunits of phosphatases PP1 and PP2A10.1038/s41467-020-17334-x2041-1723https://doaj.org/article/ad478d61be2b4e37af71927c9d84077e2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17334-xhttps://doaj.org/toc/2041-1723The substrate specificity of phosphoprotein phosphatases PP1 and PP2A depends on their catalytic and regulatory subunits. Using proteomics approaches, the authors here provide insights into the sequence specificity of the catalytic subunits and their distinct contributions to PP1 and PP2A selectivity.Bernhard HoermannThomas KokotDominic HelmStephanie HeinzlmeirJeremy E. ChojnackiThomas SchubertChristina LudwigAnna BerteottiNils KurzawaBernhard KusterMikhail M. SavitskiMaja KöhnNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bernhard Hoermann Thomas Kokot Dominic Helm Stephanie Heinzlmeir Jeremy E. Chojnacki Thomas Schubert Christina Ludwig Anna Berteotti Nils Kurzawa Bernhard Kuster Mikhail M. Savitski Maja Köhn Dissecting the sequence determinants for dephosphorylation by the catalytic subunits of phosphatases PP1 and PP2A
description	The substrate specificity of phosphoprotein phosphatases PP1 and PP2A depends on their catalytic and regulatory subunits. Using proteomics approaches, the authors here provide insights into the sequence specificity of the catalytic subunits and their distinct contributions to PP1 and PP2A selectivity.
format	article
author	Bernhard Hoermann Thomas Kokot Dominic Helm Stephanie Heinzlmeir Jeremy E. Chojnacki Thomas Schubert Christina Ludwig Anna Berteotti Nils Kurzawa Bernhard Kuster Mikhail M. Savitski Maja Köhn
author_facet	Bernhard Hoermann Thomas Kokot Dominic Helm Stephanie Heinzlmeir Jeremy E. Chojnacki Thomas Schubert Christina Ludwig Anna Berteotti Nils Kurzawa Bernhard Kuster Mikhail M. Savitski Maja Köhn
author_sort	Bernhard Hoermann
title	Dissecting the sequence determinants for dephosphorylation by the catalytic subunits of phosphatases PP1 and PP2A
title_short	Dissecting the sequence determinants for dephosphorylation by the catalytic subunits of phosphatases PP1 and PP2A
title_full	Dissecting the sequence determinants for dephosphorylation by the catalytic subunits of phosphatases PP1 and PP2A
title_fullStr	Dissecting the sequence determinants for dephosphorylation by the catalytic subunits of phosphatases PP1 and PP2A
title_full_unstemmed	Dissecting the sequence determinants for dephosphorylation by the catalytic subunits of phosphatases PP1 and PP2A
title_sort	dissecting the sequence determinants for dephosphorylation by the catalytic subunits of phosphatases pp1 and pp2a
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/ad478d61be2b4e37af71927c9d84077e
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Dissecting the sequence determinants for dephosphorylation by the catalytic subunits of phosphatases PP1 and PP2A

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