The MDR1/ABCB1 gene rs1045642 polymorphism in colorectal cancer
Introduction Colorectal cancer (CRC) is one of the most frequently diagnosed tumors in Western countries. CRC is a heterogeneous group of tumors with regards to its molecular pathogenesis and genetic factors. Both genetic variations and anthropometric factors may affect morbidity in CRC patients. Th...
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2019
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oai:doaj.org-article:ad47bfa791514e9c90a4f632d30178552021-12-02T16:59:25ZThe MDR1/ABCB1 gene rs1045642 polymorphism in colorectal cancer1734-19221896-915110.5114/aoms.2017.70329https://doaj.org/article/ad47bfa791514e9c90a4f632d30178552019-12-01T00:00:00Zhttps://www.archivesofmedicalscience.com/The-MDR1-ABCB1-gene-rs1045642-polymorphism-in-colorectal-cancer,75586,0,2.htmlhttps://doaj.org/toc/1734-1922https://doaj.org/toc/1896-9151Introduction Colorectal cancer (CRC) is one of the most frequently diagnosed tumors in Western countries. CRC is a heterogeneous group of tumors with regards to its molecular pathogenesis and genetic factors. Both genetic variations and anthropometric factors may affect morbidity in CRC patients. The aim of this study was to assess the impact of multidrug resistance 1/ATP-binding cassette sub-family B member 1 gene (MDR1/ABCB1) polymorphism rs1045642 and general anthropometric factors on the CRC risk. Material and methods The study included 250 patients who underwent colonoscopy and polypectomy between 2006 and 2013 in a single endoscopy unit in Warsaw, Poland. Results The CRC was diagnosed in 50 individuals, and 200 patients were included in the control group. Cases and controls were matched for mean age and sex (p > 0.05). Factors that were found to significantly increase the risk of CRC were ulcerative colitis (8/35 in the CRC group vs. 8/181 in the control group; p = 0.001), family history of CRC (11/33 vs. 26/172; p = 0.05), and diabetes mellitus (12/34 vs. 28/170; p = 0.04). Allele T of the rs 1045642 polymorphism was more frequently present in CRC cases (in both a co-dominant and recessive model) and in males (in a co-dominant model), although these associations were not statistically significant (p > 0.05). Conclusions The MDR1/ABCB1 gene polymorphism rs 1045642 may be involved in the pathogenesis of CRC and this relationship may be sex-specific for males. However, further population studies are necessary to assess this relationship.Beata Mrozikiewicz-RakowskaMarian MalinowskiPiotr NehringJoanna Bartkowiak-WieczorekAnna BogaczEwa Żurawińska-GrzelkaPrzemysław KrasnodębskiJacek MuszyńskiTomasz GrzelaAdam PrzybyłkowskiLeszek CzupryniakTermedia Publishing Housearticlecolorectal cancerrisk factorsrs 10456642polymorphismrs 1045642MedicineRENArchives of Medical Science, Vol 16, Iss 1, Pp 112-117 (2019) |
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| topic |
colorectal cancer risk factors rs 10456642 polymorphism rs 1045642 Medicine R |
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colorectal cancer risk factors rs 10456642 polymorphism rs 1045642 Medicine R Beata Mrozikiewicz-Rakowska Marian Malinowski Piotr Nehring Joanna Bartkowiak-Wieczorek Anna Bogacz Ewa Żurawińska-Grzelka Przemysław Krasnodębski Jacek Muszyński Tomasz Grzela Adam Przybyłkowski Leszek Czupryniak The MDR1/ABCB1 gene rs1045642 polymorphism in colorectal cancer |
| description |
Introduction
Colorectal cancer (CRC) is one of the most frequently diagnosed tumors in Western countries. CRC is a heterogeneous group of tumors with regards to its molecular pathogenesis and genetic factors. Both genetic variations and anthropometric factors may affect morbidity in CRC patients. The aim of this study was to assess the impact of multidrug resistance 1/ATP-binding cassette sub-family B member 1 gene (MDR1/ABCB1) polymorphism rs1045642 and general anthropometric factors on the CRC risk.
Material and methods
The study included 250 patients who underwent colonoscopy and polypectomy between 2006 and 2013 in a single endoscopy unit in Warsaw, Poland.
Results
The CRC was diagnosed in 50 individuals, and 200 patients were included in the control group. Cases and controls were matched for mean age and sex (p > 0.05). Factors that were found to significantly increase the risk of CRC were ulcerative colitis (8/35 in the CRC group vs. 8/181 in the control group; p = 0.001), family history of CRC (11/33 vs. 26/172; p = 0.05), and diabetes mellitus (12/34 vs. 28/170; p = 0.04). Allele T of the rs 1045642 polymorphism was more frequently present in CRC cases (in both a co-dominant and recessive model) and in males (in a co-dominant model), although these associations were not statistically significant (p > 0.05).
Conclusions
The MDR1/ABCB1 gene polymorphism rs 1045642 may be involved in the pathogenesis of CRC and this relationship may be sex-specific for males. However, further population studies are necessary to assess this relationship. |
| format |
article |
| author |
Beata Mrozikiewicz-Rakowska Marian Malinowski Piotr Nehring Joanna Bartkowiak-Wieczorek Anna Bogacz Ewa Żurawińska-Grzelka Przemysław Krasnodębski Jacek Muszyński Tomasz Grzela Adam Przybyłkowski Leszek Czupryniak |
| author_facet |
Beata Mrozikiewicz-Rakowska Marian Malinowski Piotr Nehring Joanna Bartkowiak-Wieczorek Anna Bogacz Ewa Żurawińska-Grzelka Przemysław Krasnodębski Jacek Muszyński Tomasz Grzela Adam Przybyłkowski Leszek Czupryniak |
| author_sort |
Beata Mrozikiewicz-Rakowska |
| title |
The MDR1/ABCB1 gene rs1045642 polymorphism in colorectal cancer |
| title_short |
The MDR1/ABCB1 gene rs1045642 polymorphism in colorectal cancer |
| title_full |
The MDR1/ABCB1 gene rs1045642 polymorphism in colorectal cancer |
| title_fullStr |
The MDR1/ABCB1 gene rs1045642 polymorphism in colorectal cancer |
| title_full_unstemmed |
The MDR1/ABCB1 gene rs1045642 polymorphism in colorectal cancer |
| title_sort |
mdr1/abcb1 gene rs1045642 polymorphism in colorectal cancer |
| publisher |
Termedia Publishing House |
| publishDate |
2019 |
| url |
https://doaj.org/article/ad47bfa791514e9c90a4f632d3017855 |
| work_keys_str_mv |
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