Contact sensitization in patients with chronic venous insufficiency and the impact of the disease duration on the risk of occurrence of contact sensitization

Background/Aim. Development of allergic contact der-matitis as a complication of treatment of chronic venous insufficiency (CVI) is well known. The aim of this study was to determine the incidence and risk of eczematous contact sensitization in patients with CVI, as well as the correlation between d...

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Autores principales:	Vujanović Ljuba, Jovanović Marina, Matić Milan, Jakovljević Sanja, Golušin Zoran
Formato:	article
Lenguaje:	EN SR
Publicado:	Military Health Department, Ministry of Defance, Serbia 2021
Materias:	dermatitis, contact incidence risk assessment venous insufficiency Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/ad5162088b4646bbbe190c037376a83c
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spelling	oai:doaj.org-article:ad5162088b4646bbbe190c037376a83c2021-12-01T13:00:25ZContact sensitization in patients with chronic venous insufficiency and the impact of the disease duration on the risk of occurrence of contact sensitization0042-84502406-072010.2298/VSP190821023Vhttps://doaj.org/article/ad5162088b4646bbbe190c037376a83c2021-01-01T00:00:00Zhttp://www.doiserbia.nb.rs/img/doi/0042-8450/2021/0042-84502000023V.pdfhttps://doaj.org/toc/0042-8450https://doaj.org/toc/2406-0720Background/Aim. Development of allergic contact der-matitis as a complication of treatment of chronic venous insufficiency (CVI) is well known. The aim of this study was to determine the incidence and risk of eczematous contact sensitization in patients with CVI, as well as the correlation between disease duration and contact sensitization. Methods. The study involved 266 subjects examined during three-year-period who were divided into two groups: the study group included patients with CVI referred for allergy testing due to suspected contact dermatitis, and the control group included the ones without CVI patch tested for suspected contact dermatitis. The severity of CVI was assessed by Clinical Etiology-Anatomy-Pathophysiology (CEAP) classification. Thereafter, each patient underwent patch testing. Results. The incidence of contact sensitization among patients with CVI was 49.3%. In these patients, the incidence of contact sensitization to the European standard battery of allergens was 31.55%; to the battery specific for CVI it was 28.45%. Patients with CVI had a 2.45-fold higher risk for developing contact sensitization to two or more allergens, and a 3.69-fold higher risk for developing contact sensitization to five or more allergens compared to those without CVI. The prevalence of contact sensitization in patients with CVI was not significantly different from those without CVI. There was a positive correlation between the incidence of contact sensitization and the duration of the disease. Conclusion. Patients with CVI had no statistically significantly distinct contact sensitization prevalence and had 2.45 and 3.69 times higher risk to manifest contact sensitization to two and more allergens and five and more allergens, respectively, than patients with no CVI. The positive correlation between frequency of contact sensitization and disease duration was found.Vujanović LjubaJovanović MarinaMatić MilanJakovljević SanjaGolušin ZoranMilitary Health Department, Ministry of Defance, Serbiaarticledermatitis, contactincidencerisk assessmentvenous insufficiencyMedicine (General)R5-920ENSRVojnosanitetski Pregled, Vol 78, Iss 11, Pp 1125-1132 (2021)
institution	DOAJ
collection	DOAJ
language	EN SR
topic	dermatitis, contact incidence risk assessment venous insufficiency Medicine (General) R5-920
spellingShingle	dermatitis, contact incidence risk assessment venous insufficiency Medicine (General) R5-920 Vujanović Ljuba Jovanović Marina Matić Milan Jakovljević Sanja Golušin Zoran Contact sensitization in patients with chronic venous insufficiency and the impact of the disease duration on the risk of occurrence of contact sensitization
description	Background/Aim. Development of allergic contact der-matitis as a complication of treatment of chronic venous insufficiency (CVI) is well known. The aim of this study was to determine the incidence and risk of eczematous contact sensitization in patients with CVI, as well as the correlation between disease duration and contact sensitization. Methods. The study involved 266 subjects examined during three-year-period who were divided into two groups: the study group included patients with CVI referred for allergy testing due to suspected contact dermatitis, and the control group included the ones without CVI patch tested for suspected contact dermatitis. The severity of CVI was assessed by Clinical Etiology-Anatomy-Pathophysiology (CEAP) classification. Thereafter, each patient underwent patch testing. Results. The incidence of contact sensitization among patients with CVI was 49.3%. In these patients, the incidence of contact sensitization to the European standard battery of allergens was 31.55%; to the battery specific for CVI it was 28.45%. Patients with CVI had a 2.45-fold higher risk for developing contact sensitization to two or more allergens, and a 3.69-fold higher risk for developing contact sensitization to five or more allergens compared to those without CVI. The prevalence of contact sensitization in patients with CVI was not significantly different from those without CVI. There was a positive correlation between the incidence of contact sensitization and the duration of the disease. Conclusion. Patients with CVI had no statistically significantly distinct contact sensitization prevalence and had 2.45 and 3.69 times higher risk to manifest contact sensitization to two and more allergens and five and more allergens, respectively, than patients with no CVI. The positive correlation between frequency of contact sensitization and disease duration was found.
format	article
author	Vujanović Ljuba Jovanović Marina Matić Milan Jakovljević Sanja Golušin Zoran
author_facet	Vujanović Ljuba Jovanović Marina Matić Milan Jakovljević Sanja Golušin Zoran
author_sort	Vujanović Ljuba
title	Contact sensitization in patients with chronic venous insufficiency and the impact of the disease duration on the risk of occurrence of contact sensitization
title_short	Contact sensitization in patients with chronic venous insufficiency and the impact of the disease duration on the risk of occurrence of contact sensitization
title_full	Contact sensitization in patients with chronic venous insufficiency and the impact of the disease duration on the risk of occurrence of contact sensitization
title_fullStr	Contact sensitization in patients with chronic venous insufficiency and the impact of the disease duration on the risk of occurrence of contact sensitization
title_full_unstemmed	Contact sensitization in patients with chronic venous insufficiency and the impact of the disease duration on the risk of occurrence of contact sensitization
title_sort	contact sensitization in patients with chronic venous insufficiency and the impact of the disease duration on the risk of occurrence of contact sensitization
publisher	Military Health Department, Ministry of Defance, Serbia
publishDate	2021
url	https://doaj.org/article/ad5162088b4646bbbe190c037376a83c
work_keys_str_mv	AT vujanovicljuba contactsensitizationinpatientswithchronicvenousinsufficiencyandtheimpactofthediseasedurationontheriskofoccurrenceofcontactsensitization AT jovanovicmarina contactsensitizationinpatientswithchronicvenousinsufficiencyandtheimpactofthediseasedurationontheriskofoccurrenceofcontactsensitization AT maticmilan contactsensitizationinpatientswithchronicvenousinsufficiencyandtheimpactofthediseasedurationontheriskofoccurrenceofcontactsensitization AT jakovljevicsanja contactsensitizationinpatientswithchronicvenousinsufficiencyandtheimpactofthediseasedurationontheriskofoccurrenceofcontactsensitization AT golusinzoran contactsensitizationinpatientswithchronicvenousinsufficiencyandtheimpactofthediseasedurationontheriskofoccurrenceofcontactsensitization
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Contact sensitization in patients with chronic venous insufficiency and the impact of the disease duration on the risk of occurrence of contact sensitization

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