Sarcopenia increases the risk of post-operative recurrence in patients with non-small cell lung cancer.

<h4>Background</h4>Sarcopenia is among the most prevalent and serious cancer-related symptom, and is strongly correlated with a poor prognosis. Moreover, it reportedly predicts poor prognosis after surgery in patients with lung cancer. However, it is unclear whether sarcopenia directly a...

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Autores principales:	Yo Kawaguchi, Jun Hanaoka, Yasuhiko Ohshio, Keigo Okamoto, Ryosuke Kaku, Kazuki Hayashi, Takuya Shiratori, Akira Akazawa
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ad54791e9b7e4efa8b1381cc5b65ed48
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spelling	oai:doaj.org-article:ad54791e9b7e4efa8b1381cc5b65ed482021-12-02T20:14:16ZSarcopenia increases the risk of post-operative recurrence in patients with non-small cell lung cancer.1932-620310.1371/journal.pone.0257594https://doaj.org/article/ad54791e9b7e4efa8b1381cc5b65ed482021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0257594https://doaj.org/toc/1932-6203<h4>Background</h4>Sarcopenia is among the most prevalent and serious cancer-related symptom, and is strongly correlated with a poor prognosis. Moreover, it reportedly predicts poor prognosis after surgery in patients with lung cancer. However, it is unclear whether sarcopenia directly affects post-operative recurrence. The purpose of this study was to evaluate whether sarcopenia can be a risk indicator for post-operative recurrence, and whether it suppresses anti-tumor immunity, in a cohort of patients with resected non-small cell lung cancer.<h4>Methods</h4>This study retrospectively reviewed the data of 256 consecutive patients who underwent curative lobectomy and lymph node dissection for non-small cell lung cancer at our institution. The psoas muscle mass index was calculated as the total psoas muscle area at the third lumbar vertebral level/height2 (cm2/m2). Sarcopenia was defined by a psoas muscle mass index of under 5.03 cm2/m2 and 3.17 cm2/m2 in male and female patients, respectively. Post-operative prognosis and cumulative incidence of recurrence rates were calculated.<h4>Results</h4>The 5-year overall survival and disease-free survival rates post-surgery were 59.5% and 38.6%, respectively, in patients with sarcopenia versus 81.1% and 72.1%, respectively, in patients without sarcopenia (p < 0.001). The 5-year cumulative incidence of recurrence rate in patients with sarcopenia was significantly higher than those without sarcopenia (49.9% versus 22.4%, respectively) in every pathological stage. Pathological stages II and III (hazard ratio, 3.36; p = 0.004), histological type (hazard ratio, 2.31; p = 0.025), and sarcopenia (hazard ratio, 2.52; p = 0.001) were independent risk factors for post-operative recurrence according to multivariate analysis.<h4>Conclusion</h4>Sarcopenia is a risk indicator for post-operative recurrence in patients with non-small cell lung cancer.Yo KawaguchiJun HanaokaYasuhiko OhshioKeigo OkamotoRyosuke KakuKazuki HayashiTakuya ShiratoriAkira AkazawaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0257594 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yo Kawaguchi Jun Hanaoka Yasuhiko Ohshio Keigo Okamoto Ryosuke Kaku Kazuki Hayashi Takuya Shiratori Akira Akazawa Sarcopenia increases the risk of post-operative recurrence in patients with non-small cell lung cancer.
description	<h4>Background</h4>Sarcopenia is among the most prevalent and serious cancer-related symptom, and is strongly correlated with a poor prognosis. Moreover, it reportedly predicts poor prognosis after surgery in patients with lung cancer. However, it is unclear whether sarcopenia directly affects post-operative recurrence. The purpose of this study was to evaluate whether sarcopenia can be a risk indicator for post-operative recurrence, and whether it suppresses anti-tumor immunity, in a cohort of patients with resected non-small cell lung cancer.<h4>Methods</h4>This study retrospectively reviewed the data of 256 consecutive patients who underwent curative lobectomy and lymph node dissection for non-small cell lung cancer at our institution. The psoas muscle mass index was calculated as the total psoas muscle area at the third lumbar vertebral level/height2 (cm2/m2). Sarcopenia was defined by a psoas muscle mass index of under 5.03 cm2/m2 and 3.17 cm2/m2 in male and female patients, respectively. Post-operative prognosis and cumulative incidence of recurrence rates were calculated.<h4>Results</h4>The 5-year overall survival and disease-free survival rates post-surgery were 59.5% and 38.6%, respectively, in patients with sarcopenia versus 81.1% and 72.1%, respectively, in patients without sarcopenia (p < 0.001). The 5-year cumulative incidence of recurrence rate in patients with sarcopenia was significantly higher than those without sarcopenia (49.9% versus 22.4%, respectively) in every pathological stage. Pathological stages II and III (hazard ratio, 3.36; p = 0.004), histological type (hazard ratio, 2.31; p = 0.025), and sarcopenia (hazard ratio, 2.52; p = 0.001) were independent risk factors for post-operative recurrence according to multivariate analysis.<h4>Conclusion</h4>Sarcopenia is a risk indicator for post-operative recurrence in patients with non-small cell lung cancer.
format	article
author	Yo Kawaguchi Jun Hanaoka Yasuhiko Ohshio Keigo Okamoto Ryosuke Kaku Kazuki Hayashi Takuya Shiratori Akira Akazawa
author_facet	Yo Kawaguchi Jun Hanaoka Yasuhiko Ohshio Keigo Okamoto Ryosuke Kaku Kazuki Hayashi Takuya Shiratori Akira Akazawa
author_sort	Yo Kawaguchi
title	Sarcopenia increases the risk of post-operative recurrence in patients with non-small cell lung cancer.
title_short	Sarcopenia increases the risk of post-operative recurrence in patients with non-small cell lung cancer.
title_full	Sarcopenia increases the risk of post-operative recurrence in patients with non-small cell lung cancer.
title_fullStr	Sarcopenia increases the risk of post-operative recurrence in patients with non-small cell lung cancer.
title_full_unstemmed	Sarcopenia increases the risk of post-operative recurrence in patients with non-small cell lung cancer.
title_sort	sarcopenia increases the risk of post-operative recurrence in patients with non-small cell lung cancer.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/ad54791e9b7e4efa8b1381cc5b65ed48
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Sarcopenia increases the risk of post-operative recurrence in patients with non-small cell lung cancer.

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