Sequence-encoded and composition-dependent protein-RNA interactions control multiphasic condensate morphologies

Liquid ribonucleoprotein condensates typically involve a dense network of multiple proteins and RNAs. Here, the authors employ a minimal system composed of Prion-like polypeptides (PLP), Arg-rich polypeptides (RRP), and RNA to form biphasic condensates with diverse morphologies tunable via mixture s...

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Autores principales:	Taranpreet Kaur, Muralikrishna Raju, Ibraheem Alshareedah, Richoo B. Davis, Davit A. Potoyan, Priya R. Banerjee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ad568833c0a0495887cb73f57905ddcf
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spelling	oai:doaj.org-article:ad568833c0a0495887cb73f57905ddcf2021-12-02T14:26:51ZSequence-encoded and composition-dependent protein-RNA interactions control multiphasic condensate morphologies10.1038/s41467-021-21089-42041-1723https://doaj.org/article/ad568833c0a0495887cb73f57905ddcf2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21089-4https://doaj.org/toc/2041-1723Liquid ribonucleoprotein condensates typically involve a dense network of multiple proteins and RNAs. Here, the authors employ a minimal system composed of Prion-like polypeptides (PLP), Arg-rich polypeptides (RRP), and RNA to form biphasic condensates with diverse morphologies tunable via mixture stoichiometry and hierarchy of intermolecular interactions.Taranpreet KaurMuralikrishna RajuIbraheem AlshareedahRichoo B. DavisDavit A. PotoyanPriya R. BanerjeeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Taranpreet Kaur Muralikrishna Raju Ibraheem Alshareedah Richoo B. Davis Davit A. Potoyan Priya R. Banerjee Sequence-encoded and composition-dependent protein-RNA interactions control multiphasic condensate morphologies
description	Liquid ribonucleoprotein condensates typically involve a dense network of multiple proteins and RNAs. Here, the authors employ a minimal system composed of Prion-like polypeptides (PLP), Arg-rich polypeptides (RRP), and RNA to form biphasic condensates with diverse morphologies tunable via mixture stoichiometry and hierarchy of intermolecular interactions.
format	article
author	Taranpreet Kaur Muralikrishna Raju Ibraheem Alshareedah Richoo B. Davis Davit A. Potoyan Priya R. Banerjee
author_facet	Taranpreet Kaur Muralikrishna Raju Ibraheem Alshareedah Richoo B. Davis Davit A. Potoyan Priya R. Banerjee
author_sort	Taranpreet Kaur
title	Sequence-encoded and composition-dependent protein-RNA interactions control multiphasic condensate morphologies
title_short	Sequence-encoded and composition-dependent protein-RNA interactions control multiphasic condensate morphologies
title_full	Sequence-encoded and composition-dependent protein-RNA interactions control multiphasic condensate morphologies
title_fullStr	Sequence-encoded and composition-dependent protein-RNA interactions control multiphasic condensate morphologies
title_full_unstemmed	Sequence-encoded and composition-dependent protein-RNA interactions control multiphasic condensate morphologies
title_sort	sequence-encoded and composition-dependent protein-rna interactions control multiphasic condensate morphologies
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ad568833c0a0495887cb73f57905ddcf
work_keys_str_mv	AT taranpreetkaur sequenceencodedandcompositiondependentproteinrnainteractionscontrolmultiphasiccondensatemorphologies AT muralikrishnaraju sequenceencodedandcompositiondependentproteinrnainteractionscontrolmultiphasiccondensatemorphologies AT ibraheemalshareedah sequenceencodedandcompositiondependentproteinrnainteractionscontrolmultiphasiccondensatemorphologies AT richoobdavis sequenceencodedandcompositiondependentproteinrnainteractionscontrolmultiphasiccondensatemorphologies AT davitapotoyan sequenceencodedandcompositiondependentproteinrnainteractionscontrolmultiphasiccondensatemorphologies AT priyarbanerjee sequenceencodedandcompositiondependentproteinrnainteractionscontrolmultiphasiccondensatemorphologies
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Sequence-encoded and composition-dependent protein-RNA interactions control multiphasic condensate morphologies

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