Long-term effect of continuous positive airway pressure therapy on blood pressure in patients with obstructive sleep apnea

Abstract Obstructive sleep apnea (OSA) is a common cause of hypertension. Previous studies have demonstrated beneficial short-term effects of continuous positive airway pressure (CPAP) therapy on blood pressure. However, long-term antihypertensive effects of CPAP have not been properly verified. Thi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ryutaro Shirahama, Takeshi Tanigawa, Yoshifumi Ida, Kento Fukuhisa, Rika Tanaka, Kiyohide Tomooka, Fan-Yun Lan, Ai Ikeda, Hiroo Wada, Stefanos N. Kales
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ad57be5f6f1c483e83bf18ba39776e98
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ad57be5f6f1c483e83bf18ba39776e98
record_format	dspace
spelling	oai:doaj.org-article:ad57be5f6f1c483e83bf18ba39776e982021-12-02T19:16:46ZLong-term effect of continuous positive airway pressure therapy on blood pressure in patients with obstructive sleep apnea10.1038/s41598-021-98553-02045-2322https://doaj.org/article/ad57be5f6f1c483e83bf18ba39776e982021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98553-0https://doaj.org/toc/2045-2322Abstract Obstructive sleep apnea (OSA) is a common cause of hypertension. Previous studies have demonstrated beneficial short-term effects of continuous positive airway pressure (CPAP) therapy on blood pressure. However, long-term antihypertensive effects of CPAP have not been properly verified. This study examined the longitudinal effect of CPAP therapy adherence on blood pressure among OSA patients. All patients diagnosed with OSA and undergoing subsequent CPAP therapy at a Kanagawa-area sleep clinic were clinically followed for 24 months to examine CPAP adherence, as well as longitudinal changes in blood pressure and body weight because it may become a confound factor for changes in blood pressure. The hours of CPAP usage were collected over the course of 30 nights prior to each follow-up visit (1st, 3rd, 6th, 12th, and 24th month). The relationship between CPAP adherence and blood pressure was analyzed using mixed-effect logistic regression models. A total of 918 OSA patients were enrolled in the study. We found a significant reduction in diastolic blood pressure among patients with good CPAP adherence during the 24-month follow-up period (β = − 0.13, p = 0.03), when compared to the group with poor CPAP adherence. No significant association was found between CPAP adherence and weight loss (β = − 0.02, p = 0.59). Long-term, good CPAP therapy adherence was associated with lower diastolic blood pressure without significant weight loss.Ryutaro ShirahamaTakeshi TanigawaYoshifumi IdaKento FukuhisaRika TanakaKiyohide TomookaFan-Yun LanAi IkedaHiroo WadaStefanos N. KalesNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ryutaro Shirahama Takeshi Tanigawa Yoshifumi Ida Kento Fukuhisa Rika Tanaka Kiyohide Tomooka Fan-Yun Lan Ai Ikeda Hiroo Wada Stefanos N. Kales Long-term effect of continuous positive airway pressure therapy on blood pressure in patients with obstructive sleep apnea
description	Abstract Obstructive sleep apnea (OSA) is a common cause of hypertension. Previous studies have demonstrated beneficial short-term effects of continuous positive airway pressure (CPAP) therapy on blood pressure. However, long-term antihypertensive effects of CPAP have not been properly verified. This study examined the longitudinal effect of CPAP therapy adherence on blood pressure among OSA patients. All patients diagnosed with OSA and undergoing subsequent CPAP therapy at a Kanagawa-area sleep clinic were clinically followed for 24 months to examine CPAP adherence, as well as longitudinal changes in blood pressure and body weight because it may become a confound factor for changes in blood pressure. The hours of CPAP usage were collected over the course of 30 nights prior to each follow-up visit (1st, 3rd, 6th, 12th, and 24th month). The relationship between CPAP adherence and blood pressure was analyzed using mixed-effect logistic regression models. A total of 918 OSA patients were enrolled in the study. We found a significant reduction in diastolic blood pressure among patients with good CPAP adherence during the 24-month follow-up period (β = − 0.13, p = 0.03), when compared to the group with poor CPAP adherence. No significant association was found between CPAP adherence and weight loss (β = − 0.02, p = 0.59). Long-term, good CPAP therapy adherence was associated with lower diastolic blood pressure without significant weight loss.
format	article
author	Ryutaro Shirahama Takeshi Tanigawa Yoshifumi Ida Kento Fukuhisa Rika Tanaka Kiyohide Tomooka Fan-Yun Lan Ai Ikeda Hiroo Wada Stefanos N. Kales
author_facet	Ryutaro Shirahama Takeshi Tanigawa Yoshifumi Ida Kento Fukuhisa Rika Tanaka Kiyohide Tomooka Fan-Yun Lan Ai Ikeda Hiroo Wada Stefanos N. Kales
author_sort	Ryutaro Shirahama
title	Long-term effect of continuous positive airway pressure therapy on blood pressure in patients with obstructive sleep apnea
title_short	Long-term effect of continuous positive airway pressure therapy on blood pressure in patients with obstructive sleep apnea
title_full	Long-term effect of continuous positive airway pressure therapy on blood pressure in patients with obstructive sleep apnea
title_fullStr	Long-term effect of continuous positive airway pressure therapy on blood pressure in patients with obstructive sleep apnea
title_full_unstemmed	Long-term effect of continuous positive airway pressure therapy on blood pressure in patients with obstructive sleep apnea
title_sort	long-term effect of continuous positive airway pressure therapy on blood pressure in patients with obstructive sleep apnea
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ad57be5f6f1c483e83bf18ba39776e98
work_keys_str_mv	AT ryutaroshirahama longtermeffectofcontinuouspositiveairwaypressuretherapyonbloodpressureinpatientswithobstructivesleepapnea AT takeshitanigawa longtermeffectofcontinuouspositiveairwaypressuretherapyonbloodpressureinpatientswithobstructivesleepapnea AT yoshifumiida longtermeffectofcontinuouspositiveairwaypressuretherapyonbloodpressureinpatientswithobstructivesleepapnea AT kentofukuhisa longtermeffectofcontinuouspositiveairwaypressuretherapyonbloodpressureinpatientswithobstructivesleepapnea AT rikatanaka longtermeffectofcontinuouspositiveairwaypressuretherapyonbloodpressureinpatientswithobstructivesleepapnea AT kiyohidetomooka longtermeffectofcontinuouspositiveairwaypressuretherapyonbloodpressureinpatientswithobstructivesleepapnea AT fanyunlan longtermeffectofcontinuouspositiveairwaypressuretherapyonbloodpressureinpatientswithobstructivesleepapnea AT aiikeda longtermeffectofcontinuouspositiveairwaypressuretherapyonbloodpressureinpatientswithobstructivesleepapnea AT hiroowada longtermeffectofcontinuouspositiveairwaypressuretherapyonbloodpressureinpatientswithobstructivesleepapnea AT stefanosnkales longtermeffectofcontinuouspositiveairwaypressuretherapyonbloodpressureinpatientswithobstructivesleepapnea
_version_	1718376931013951488

Long-term effect of continuous positive airway pressure therapy on blood pressure in patients with obstructive sleep apnea

Ejemplares similares