Early life neonicotinoid exposure results in proximal benefits and ultimate carryover effects

Abstract Neonicotinoids are insecticides widely used as seed treatments that appear to have multiple negative effects on birds at a diversity of biological scales. Adult birds exposed to a low dose of imidacloprid, one of the most commonly used neonicotinoids, presented reduced fat stores, delayed m...

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Autores principales:	Thomas Zgirski, Pierre Legagneux, Olivier Chastel, Lyette Regimbald, Louise Prouteau, Audrey Le Pogam, Hélène Budzinski, Oliver P. Love, François Vézina
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ad5ac47b80c0448f904bd7f63777a8e6
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spelling	oai:doaj.org-article:ad5ac47b80c0448f904bd7f63777a8e62021-12-02T16:23:42ZEarly life neonicotinoid exposure results in proximal benefits and ultimate carryover effects10.1038/s41598-021-93894-22045-2322https://doaj.org/article/ad5ac47b80c0448f904bd7f63777a8e62021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93894-2https://doaj.org/toc/2045-2322Abstract Neonicotinoids are insecticides widely used as seed treatments that appear to have multiple negative effects on birds at a diversity of biological scales. Adult birds exposed to a low dose of imidacloprid, one of the most commonly used neonicotinoids, presented reduced fat stores, delayed migration and potentially altered orientation. However, little is known on the effect of imidacloprid on birds growth rate despite studies that have documented disruptive effects of low imidacloprid doses on thyroid gland communication. We performed a $$2 \times 2$$ 2 × 2 factorial design experiment in Zebra finches, in which nestling birds were exposed to a very low dose (0.205 mg kg body $$\hbox {mass}^{-1}$$ mass - 1 ) of imidacloprid combined with food restriction during posthatch development. During the early developmental period, imidacloprid exposure resulted in an improvement of body condition index in treated nestlings relative to controls. Imidacloprid also led to compensatory growth in food restricted nestlings. This early life neonicotinoid exposure also carried over to adult age, with exposed birds showing higher lean mass and basal metabolic rate than controls at ages of 90–800 days. This study presents the first evidence that very low-dose neonicotinoid exposure during early life can permanently alter adult phenotype in birds.Thomas ZgirskiPierre LegagneuxOlivier ChastelLyette RegimbaldLouise ProuteauAudrey Le PogamHélène BudzinskiOliver P. LoveFrançois VézinaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Thomas Zgirski Pierre Legagneux Olivier Chastel Lyette Regimbald Louise Prouteau Audrey Le Pogam Hélène Budzinski Oliver P. Love François Vézina Early life neonicotinoid exposure results in proximal benefits and ultimate carryover effects
description	Abstract Neonicotinoids are insecticides widely used as seed treatments that appear to have multiple negative effects on birds at a diversity of biological scales. Adult birds exposed to a low dose of imidacloprid, one of the most commonly used neonicotinoids, presented reduced fat stores, delayed migration and potentially altered orientation. However, little is known on the effect of imidacloprid on birds growth rate despite studies that have documented disruptive effects of low imidacloprid doses on thyroid gland communication. We performed a $$2 \times 2$$ 2 × 2 factorial design experiment in Zebra finches, in which nestling birds were exposed to a very low dose (0.205 mg kg body $$\hbox {mass}^{-1}$$ mass - 1 ) of imidacloprid combined with food restriction during posthatch development. During the early developmental period, imidacloprid exposure resulted in an improvement of body condition index in treated nestlings relative to controls. Imidacloprid also led to compensatory growth in food restricted nestlings. This early life neonicotinoid exposure also carried over to adult age, with exposed birds showing higher lean mass and basal metabolic rate than controls at ages of 90–800 days. This study presents the first evidence that very low-dose neonicotinoid exposure during early life can permanently alter adult phenotype in birds.
format	article
author	Thomas Zgirski Pierre Legagneux Olivier Chastel Lyette Regimbald Louise Prouteau Audrey Le Pogam Hélène Budzinski Oliver P. Love François Vézina
author_facet	Thomas Zgirski Pierre Legagneux Olivier Chastel Lyette Regimbald Louise Prouteau Audrey Le Pogam Hélène Budzinski Oliver P. Love François Vézina
author_sort	Thomas Zgirski
title	Early life neonicotinoid exposure results in proximal benefits and ultimate carryover effects
title_short	Early life neonicotinoid exposure results in proximal benefits and ultimate carryover effects
title_full	Early life neonicotinoid exposure results in proximal benefits and ultimate carryover effects
title_fullStr	Early life neonicotinoid exposure results in proximal benefits and ultimate carryover effects
title_full_unstemmed	Early life neonicotinoid exposure results in proximal benefits and ultimate carryover effects
title_sort	early life neonicotinoid exposure results in proximal benefits and ultimate carryover effects
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ad5ac47b80c0448f904bd7f63777a8e6
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Early life neonicotinoid exposure results in proximal benefits and ultimate carryover effects

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