Chronic nicotine increases midbrain dopamine neuron activity and biases individual strategies towards reduced exploration in mice

Chronic nicotine increases midbrain dopamine neuron activity and biases individual strategies towards reduced exploration in mice

Chronic nicotine exposure impacts various components of decision-making processes, such as exploratory behaviors. Here, the authors identify the cellular mechanism and show that chronic nicotine exposure increases the tonic activity of VTA dopaminergic neurons and reduces exploration in mice.

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Detalles Bibliográficos
Autores principales: Malou Dongelmans, Romain Durand-de Cuttoli, Claire Nguyen, Maxime Come, Etienne K. Duranté, Damien Lemoine, Raphaël Brito, Tarek Ahmed Yahia, Sarah Mondoloni, Steve Didienne, Elise Bousseyrol, Bernadette Hannesse, Lauren M. Reynolds, Nicolas Torquet, Deniz Dalkara, Fabio Marti, Alexandre Mourot, Jérémie Naudé, Philippe Faure
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/ad5caf779392407fa4039e76c1116fb7
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Descripción
Sumario:Chronic nicotine exposure impacts various components of decision-making processes, such as exploratory behaviors. Here, the authors identify the cellular mechanism and show that chronic nicotine exposure increases the tonic activity of VTA dopaminergic neurons and reduces exploration in mice.

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