Chronic nicotine increases midbrain dopamine neuron activity and biases individual strategies towards reduced exploration in mice
Chronic nicotine exposure impacts various components of decision-making processes, such as exploratory behaviors. Here, the authors identify the cellular mechanism and show that chronic nicotine exposure increases the tonic activity of VTA dopaminergic neurons and reduces exploration in mice.
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Nature Portfolio
2021
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oai:doaj.org-article:ad5caf779392407fa4039e76c1116fb72021-11-28T12:35:35ZChronic nicotine increases midbrain dopamine neuron activity and biases individual strategies towards reduced exploration in mice10.1038/s41467-021-27268-72041-1723https://doaj.org/article/ad5caf779392407fa4039e76c1116fb72021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27268-7https://doaj.org/toc/2041-1723Chronic nicotine exposure impacts various components of decision-making processes, such as exploratory behaviors. Here, the authors identify the cellular mechanism and show that chronic nicotine exposure increases the tonic activity of VTA dopaminergic neurons and reduces exploration in mice.Malou DongelmansRomain Durand-de CuttoliClaire NguyenMaxime ComeEtienne K. DurantéDamien LemoineRaphaël BritoTarek Ahmed YahiaSarah MondoloniSteve DidienneElise BousseyrolBernadette HannesseLauren M. ReynoldsNicolas TorquetDeniz DalkaraFabio MartiAlexandre MourotJérémie NaudéPhilippe FaureNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Science Q |
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Science Q Malou Dongelmans Romain Durand-de Cuttoli Claire Nguyen Maxime Come Etienne K. Duranté Damien Lemoine Raphaël Brito Tarek Ahmed Yahia Sarah Mondoloni Steve Didienne Elise Bousseyrol Bernadette Hannesse Lauren M. Reynolds Nicolas Torquet Deniz Dalkara Fabio Marti Alexandre Mourot Jérémie Naudé Philippe Faure Chronic nicotine increases midbrain dopamine neuron activity and biases individual strategies towards reduced exploration in mice |
| description |
Chronic nicotine exposure impacts various components of decision-making processes, such as exploratory behaviors. Here, the authors identify the cellular mechanism and show that chronic nicotine exposure increases the tonic activity of VTA dopaminergic neurons and reduces exploration in mice. |
| format |
article |
| author |
Malou Dongelmans Romain Durand-de Cuttoli Claire Nguyen Maxime Come Etienne K. Duranté Damien Lemoine Raphaël Brito Tarek Ahmed Yahia Sarah Mondoloni Steve Didienne Elise Bousseyrol Bernadette Hannesse Lauren M. Reynolds Nicolas Torquet Deniz Dalkara Fabio Marti Alexandre Mourot Jérémie Naudé Philippe Faure |
| author_facet |
Malou Dongelmans Romain Durand-de Cuttoli Claire Nguyen Maxime Come Etienne K. Duranté Damien Lemoine Raphaël Brito Tarek Ahmed Yahia Sarah Mondoloni Steve Didienne Elise Bousseyrol Bernadette Hannesse Lauren M. Reynolds Nicolas Torquet Deniz Dalkara Fabio Marti Alexandre Mourot Jérémie Naudé Philippe Faure |
| author_sort |
Malou Dongelmans |
| title |
Chronic nicotine increases midbrain dopamine neuron activity and biases individual strategies towards reduced exploration in mice |
| title_short |
Chronic nicotine increases midbrain dopamine neuron activity and biases individual strategies towards reduced exploration in mice |
| title_full |
Chronic nicotine increases midbrain dopamine neuron activity and biases individual strategies towards reduced exploration in mice |
| title_fullStr |
Chronic nicotine increases midbrain dopamine neuron activity and biases individual strategies towards reduced exploration in mice |
| title_full_unstemmed |
Chronic nicotine increases midbrain dopamine neuron activity and biases individual strategies towards reduced exploration in mice |
| title_sort |
chronic nicotine increases midbrain dopamine neuron activity and biases individual strategies towards reduced exploration in mice |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/ad5caf779392407fa4039e76c1116fb7 |
| work_keys_str_mv |
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