The Potentially Therapeutic Role of EPAC in Curbing the Process of Idiopathic Pulmonary Fibrosis via Differential Cellular Pathways

Xinwei Cao,1 Yajun Li,1 Jianrong Shi,2 Huifang Tang1 1Department of Pharmacology, School of Basic Medical Sciences, Zhejiang University, Hangzhou, 310058, People’s Republic of China; 2Department of Clinical Laboratory, Children’s Hospital, Zhejiang University School of Medicine,...

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Autores principales:	Cao X, Li Y, Shi J, Tang H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	epac idiopathic pulmonary fibrosis fibroblasts cell types camp pka Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/ad5d3c3a9d8740859ab52884a897f59a
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spelling	oai:doaj.org-article:ad5d3c3a9d8740859ab52884a897f59a2021-12-02T10:35:46ZThe Potentially Therapeutic Role of EPAC in Curbing the Process of Idiopathic Pulmonary Fibrosis via Differential Cellular Pathways1178-7031https://doaj.org/article/ad5d3c3a9d8740859ab52884a897f59a2021-02-01T00:00:00Zhttps://www.dovepress.com/the-potentially-therapeutic-role-of-epac-in-curbing-the-process-of-idi-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Xinwei Cao,1 Yajun Li,1 Jianrong Shi,2 Huifang Tang1 1Department of Pharmacology, School of Basic Medical Sciences, Zhejiang University, Hangzhou, 310058, People’s Republic of China; 2Department of Clinical Laboratory, Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center For Child Health, Hangzhou, 310003, People’s Republic of ChinaCorrespondence: Jianrong ShiDepartment of Clinical Laboratory, Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center For Child Health, Hangzhou, People’s Republic of ChinaEmail shijr999@hotmail.comHuifang TangDepartment of Pharmacology, School of Basic Medical Sciences, Zhejiang University, Hangzhou, People’s Republic of ChinaEmail tanghuifang@zju.edu.cnAbstract: Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrosis disease caused by genetic susceptibility (causative) and other indirect risk factors such as smoking, micro-aspiration and air pollution. Repeated damage of lung epithelial cells can cause fibroblast activation and excessive collagen will lead the scar formation and severe fibrosis. It has been decades since drugs for the treatment of IPF were developed, but clinical choices were limited. Exchange Protein directly Activated by cAMP (EPAC), as a newly emerging cAMP (adenosine 3ʹ,5ʹ-cyclic monophosphate) downstream molecule, plays a vital role in the cellular pathways of IPF such as inhibiting fibroblast proliferation, stress fiber formation and epithelium cell adhesion, so it may be a novel target for drug development and treatment for curbing IPF. Here, we hypothesize that EPAC may participate in the signaling pathways related to IPF in different cell types (fibroblasts; airway smooth muscle cells; vascular endothelial cells; lung epithelial cells; macrophages; mesenchymal stem cells; T cells), thereby playing a potentially therapeutic role in resisting the process of fibrosis. We summarize the current correlation between EPAC and IPF in these different cell types, and further insights into EPAC will help to optimize the pharmacological treatment for IPF.Keywords: EPAC, idiopathic pulmonary fibrosis, fibroblasts, cell types, cAMP, PKACao XLi YShi JTang HDove Medical Pressarticleepacidiopathic pulmonary fibrosisfibroblastscell typescamppkaPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 14, Pp 611-619 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	epac idiopathic pulmonary fibrosis fibroblasts cell types camp pka Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	epac idiopathic pulmonary fibrosis fibroblasts cell types camp pka Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Cao X Li Y Shi J Tang H The Potentially Therapeutic Role of EPAC in Curbing the Process of Idiopathic Pulmonary Fibrosis via Differential Cellular Pathways
description	Xinwei Cao,1 Yajun Li,1 Jianrong Shi,2 Huifang Tang1 1Department of Pharmacology, School of Basic Medical Sciences, Zhejiang University, Hangzhou, 310058, People’s Republic of China; 2Department of Clinical Laboratory, Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center For Child Health, Hangzhou, 310003, People’s Republic of ChinaCorrespondence: Jianrong ShiDepartment of Clinical Laboratory, Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center For Child Health, Hangzhou, People’s Republic of ChinaEmail shijr999@hotmail.comHuifang TangDepartment of Pharmacology, School of Basic Medical Sciences, Zhejiang University, Hangzhou, People’s Republic of ChinaEmail tanghuifang@zju.edu.cnAbstract: Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrosis disease caused by genetic susceptibility (causative) and other indirect risk factors such as smoking, micro-aspiration and air pollution. Repeated damage of lung epithelial cells can cause fibroblast activation and excessive collagen will lead the scar formation and severe fibrosis. It has been decades since drugs for the treatment of IPF were developed, but clinical choices were limited. Exchange Protein directly Activated by cAMP (EPAC), as a newly emerging cAMP (adenosine 3ʹ,5ʹ-cyclic monophosphate) downstream molecule, plays a vital role in the cellular pathways of IPF such as inhibiting fibroblast proliferation, stress fiber formation and epithelium cell adhesion, so it may be a novel target for drug development and treatment for curbing IPF. Here, we hypothesize that EPAC may participate in the signaling pathways related to IPF in different cell types (fibroblasts; airway smooth muscle cells; vascular endothelial cells; lung epithelial cells; macrophages; mesenchymal stem cells; T cells), thereby playing a potentially therapeutic role in resisting the process of fibrosis. We summarize the current correlation between EPAC and IPF in these different cell types, and further insights into EPAC will help to optimize the pharmacological treatment for IPF.Keywords: EPAC, idiopathic pulmonary fibrosis, fibroblasts, cell types, cAMP, PKA
format	article
author	Cao X Li Y Shi J Tang H
author_facet	Cao X Li Y Shi J Tang H
author_sort	Cao X
title	The Potentially Therapeutic Role of EPAC in Curbing the Process of Idiopathic Pulmonary Fibrosis via Differential Cellular Pathways
title_short	The Potentially Therapeutic Role of EPAC in Curbing the Process of Idiopathic Pulmonary Fibrosis via Differential Cellular Pathways
title_full	The Potentially Therapeutic Role of EPAC in Curbing the Process of Idiopathic Pulmonary Fibrosis via Differential Cellular Pathways
title_fullStr	The Potentially Therapeutic Role of EPAC in Curbing the Process of Idiopathic Pulmonary Fibrosis via Differential Cellular Pathways
title_full_unstemmed	The Potentially Therapeutic Role of EPAC in Curbing the Process of Idiopathic Pulmonary Fibrosis via Differential Cellular Pathways
title_sort	potentially therapeutic role of epac in curbing the process of idiopathic pulmonary fibrosis via differential cellular pathways
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/ad5d3c3a9d8740859ab52884a897f59a
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The Potentially Therapeutic Role of EPAC in Curbing the Process of Idiopathic Pulmonary Fibrosis via Differential Cellular Pathways

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