Human U90926 orthologous long non-coding RNA as a novel biomarker for visual prognosis in herpes simplex virus type-1 induced acute retinal necrosis

Abstract Acute retinal necrosis (ARN) is a form of infectious uveitis caused by alpha herpesviruses, including herpes simplex virus type 1 (HSV-1). We previously found that the long non-coding RNA (lncRNA) U90926 is upregulated in murine retinal photoreceptor cells following HSV-1 infection, leading...

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Autores principales:	Shintaro Shirahama, Kenzui Taniue, Shuhei Mitsutomi, Rie Tanaka, Toshikatsu Kaburaki, Tomohito Sato, Masaru Takeuchi, Hidetoshi Kawashima, Yoshihiro Urade, Makoto Aihara, Nobuyoshi Akimitsu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ad60a8f25b2c41328ab7650da450b5fd
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spelling	oai:doaj.org-article:ad60a8f25b2c41328ab7650da450b5fd2021-12-02T15:02:52ZHuman U90926 orthologous long non-coding RNA as a novel biomarker for visual prognosis in herpes simplex virus type-1 induced acute retinal necrosis10.1038/s41598-021-91340-x2045-2322https://doaj.org/article/ad60a8f25b2c41328ab7650da450b5fd2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91340-xhttps://doaj.org/toc/2045-2322Abstract Acute retinal necrosis (ARN) is a form of infectious uveitis caused by alpha herpesviruses, including herpes simplex virus type 1 (HSV-1). We previously found that the long non-coding RNA (lncRNA) U90926 is upregulated in murine retinal photoreceptor cells following HSV-1 infection, leading to host cell death. However, to date, an orthologous transcript has not been identified in humans. We investigated U90926 orthologous transcript in humans and examined its utility as a prognostic marker for visual acuity in patients with ARN. We identified two human orthologous transcripts (1955 and 592 bases) of lncRNA U90926. The amount of the longer human U90926 transcript was approximately 30- and 40-fold higher in the vitreous fluid of patients with ARN than in those with sarcoidosis and intraocular lymphoma, respectively. Furthermore, the expression of the longer human U90926 transcript in the vitreous fluid was highly correlated with the final best-corrected logarithm of the minimum angle of resolution visual acuity in patients with ARN (r = 0.7671, p = 0.0079). This suggests higher expression of the longer human U90926 transcript in the vitreous fluid results in worse visual prognosis; therefore, expression of the longer human U90926 transcript is a potential negative prognostic marker for visual acuity in patients with ARN.Shintaro ShirahamaKenzui TaniueShuhei MitsutomiRie TanakaToshikatsu KaburakiTomohito SatoMasaru TakeuchiHidetoshi KawashimaYoshihiro UradeMakoto AiharaNobuyoshi AkimitsuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shintaro Shirahama Kenzui Taniue Shuhei Mitsutomi Rie Tanaka Toshikatsu Kaburaki Tomohito Sato Masaru Takeuchi Hidetoshi Kawashima Yoshihiro Urade Makoto Aihara Nobuyoshi Akimitsu Human U90926 orthologous long non-coding RNA as a novel biomarker for visual prognosis in herpes simplex virus type-1 induced acute retinal necrosis
description	Abstract Acute retinal necrosis (ARN) is a form of infectious uveitis caused by alpha herpesviruses, including herpes simplex virus type 1 (HSV-1). We previously found that the long non-coding RNA (lncRNA) U90926 is upregulated in murine retinal photoreceptor cells following HSV-1 infection, leading to host cell death. However, to date, an orthologous transcript has not been identified in humans. We investigated U90926 orthologous transcript in humans and examined its utility as a prognostic marker for visual acuity in patients with ARN. We identified two human orthologous transcripts (1955 and 592 bases) of lncRNA U90926. The amount of the longer human U90926 transcript was approximately 30- and 40-fold higher in the vitreous fluid of patients with ARN than in those with sarcoidosis and intraocular lymphoma, respectively. Furthermore, the expression of the longer human U90926 transcript in the vitreous fluid was highly correlated with the final best-corrected logarithm of the minimum angle of resolution visual acuity in patients with ARN (r = 0.7671, p = 0.0079). This suggests higher expression of the longer human U90926 transcript in the vitreous fluid results in worse visual prognosis; therefore, expression of the longer human U90926 transcript is a potential negative prognostic marker for visual acuity in patients with ARN.
format	article
author	Shintaro Shirahama Kenzui Taniue Shuhei Mitsutomi Rie Tanaka Toshikatsu Kaburaki Tomohito Sato Masaru Takeuchi Hidetoshi Kawashima Yoshihiro Urade Makoto Aihara Nobuyoshi Akimitsu
author_facet	Shintaro Shirahama Kenzui Taniue Shuhei Mitsutomi Rie Tanaka Toshikatsu Kaburaki Tomohito Sato Masaru Takeuchi Hidetoshi Kawashima Yoshihiro Urade Makoto Aihara Nobuyoshi Akimitsu
author_sort	Shintaro Shirahama
title	Human U90926 orthologous long non-coding RNA as a novel biomarker for visual prognosis in herpes simplex virus type-1 induced acute retinal necrosis
title_short	Human U90926 orthologous long non-coding RNA as a novel biomarker for visual prognosis in herpes simplex virus type-1 induced acute retinal necrosis
title_full	Human U90926 orthologous long non-coding RNA as a novel biomarker for visual prognosis in herpes simplex virus type-1 induced acute retinal necrosis
title_fullStr	Human U90926 orthologous long non-coding RNA as a novel biomarker for visual prognosis in herpes simplex virus type-1 induced acute retinal necrosis
title_full_unstemmed	Human U90926 orthologous long non-coding RNA as a novel biomarker for visual prognosis in herpes simplex virus type-1 induced acute retinal necrosis
title_sort	human u90926 orthologous long non-coding rna as a novel biomarker for visual prognosis in herpes simplex virus type-1 induced acute retinal necrosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ad60a8f25b2c41328ab7650da450b5fd
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Human U90926 orthologous long non-coding RNA as a novel biomarker for visual prognosis in herpes simplex virus type-1 induced acute retinal necrosis

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