Matrix metalloprotease 9 and remodeling after myocardial infarction

The objective of the work was to study the distribution of metalloprotease 9 (MMP9) in tissues after myocardial infarction. We studied anatomopathological material from 30 patients, the primary victims of acute transmural myocardial infarction. Average age - 63,7 years. There were 18 men and 12 wome...

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Autores principales:	M. G. Shurygin, I. A. Shurygina, N. N. Dremina, O. V. Kanya
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2013
Materias:	myocardial infarction metalloprotease diagnostic method Science Q
Acceso en línea:	https://doaj.org/article/ad667f0c353f49ad81027c08da02c4b1
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spelling	oai:doaj.org-article:ad667f0c353f49ad81027c08da02c4b12021-11-23T06:14:27ZMatrix metalloprotease 9 and remodeling after myocardial infarction2541-94202587-9596https://doaj.org/article/ad667f0c353f49ad81027c08da02c4b12013-04-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/1544https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The objective of the work was to study the distribution of metalloprotease 9 (MMP9) in tissues after myocardial infarction. We studied anatomopathological material from 30 patients, the primary victims of acute transmural myocardial infarction. Average age - 63,7 years. There were 18 men and 12 women. 16 patients died in the period up to 3 days, 14 patients - in a period from 3 days to 1 month. Samples were fixed in formalin and immunohistochemical staining for MMP9 was conducted. We used rabbit IgG monoclonal antibody to MMP9 (Epitomics, Clone 1D: EP1254, Cat. N 2551-1, Lot YG 113001P) in the working dilution of 1: 100 - 1: 250. At fatal outcomes that happened within a few hours after the onset of a heart attack a large number of MMP9 was detected in neutrophils in the blood vessels at near infarction zone. In the period from 1 to 2 hours MMP9 was detected in the extracellular matrix in the area of infarction. In the period from 3 to 30 days MMP9 was detected only in fibroclasts at forming cardiosclerosis zone. Thus, the use of staining for MMP9 is convenient for determination of the time elapsed after myocardial infarction in post mortem examination.M. G. ShuryginI. A. ShuryginaN. N. DreminaO. V. KanyaScientific Сentre for Family Health and Human Reproduction Problemsarticlemyocardial infarctionmetalloproteasediagnostic methodScienceQRUActa Biomedica Scientifica, Vol 0, Iss 2(1), Pp 138-141 (2013)
institution	DOAJ
collection	DOAJ
language	RU
topic	myocardial infarction metalloprotease diagnostic method Science Q
spellingShingle	myocardial infarction metalloprotease diagnostic method Science Q M. G. Shurygin I. A. Shurygina N. N. Dremina O. V. Kanya Matrix metalloprotease 9 and remodeling after myocardial infarction
description	The objective of the work was to study the distribution of metalloprotease 9 (MMP9) in tissues after myocardial infarction. We studied anatomopathological material from 30 patients, the primary victims of acute transmural myocardial infarction. Average age - 63,7 years. There were 18 men and 12 women. 16 patients died in the period up to 3 days, 14 patients - in a period from 3 days to 1 month. Samples were fixed in formalin and immunohistochemical staining for MMP9 was conducted. We used rabbit IgG monoclonal antibody to MMP9 (Epitomics, Clone 1D: EP1254, Cat. N 2551-1, Lot YG 113001P) in the working dilution of 1: 100 - 1: 250. At fatal outcomes that happened within a few hours after the onset of a heart attack a large number of MMP9 was detected in neutrophils in the blood vessels at near infarction zone. In the period from 1 to 2 hours MMP9 was detected in the extracellular matrix in the area of infarction. In the period from 3 to 30 days MMP9 was detected only in fibroclasts at forming cardiosclerosis zone. Thus, the use of staining for MMP9 is convenient for determination of the time elapsed after myocardial infarction in post mortem examination.
format	article
author	M. G. Shurygin I. A. Shurygina N. N. Dremina O. V. Kanya
author_facet	M. G. Shurygin I. A. Shurygina N. N. Dremina O. V. Kanya
author_sort	M. G. Shurygin
title	Matrix metalloprotease 9 and remodeling after myocardial infarction
title_short	Matrix metalloprotease 9 and remodeling after myocardial infarction
title_full	Matrix metalloprotease 9 and remodeling after myocardial infarction
title_fullStr	Matrix metalloprotease 9 and remodeling after myocardial infarction
title_full_unstemmed	Matrix metalloprotease 9 and remodeling after myocardial infarction
title_sort	matrix metalloprotease 9 and remodeling after myocardial infarction
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2013
url	https://doaj.org/article/ad667f0c353f49ad81027c08da02c4b1
work_keys_str_mv	AT mgshurygin matrixmetalloprotease9andremodelingaftermyocardialinfarction AT iashurygina matrixmetalloprotease9andremodelingaftermyocardialinfarction AT nndremina matrixmetalloprotease9andremodelingaftermyocardialinfarction AT ovkanya matrixmetalloprotease9andremodelingaftermyocardialinfarction
_version_	1718417153413087232

Matrix metalloprotease 9 and remodeling after myocardial infarction

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