Microfluidic on-chip production of microgels using combined geometries

Abstract Microfluidic on-chip production of microgels using external gelation can serve numerous applications that involve encapsulation of sensitive cargos. Nevertheless, on-chip production of microgels in microfluidic devices can be challenging due to problems induced by the rapid increase in prec...

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Autores principales:	Hamed Shieh, Maryam Saadatmand, Mahnaz Eskandari, Dariush Bastani
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ad6eee67226e480dbb118d2cbaaa3c6a
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spelling	oai:doaj.org-article:ad6eee67226e480dbb118d2cbaaa3c6a2021-12-02T15:23:00ZMicrofluidic on-chip production of microgels using combined geometries10.1038/s41598-021-81214-72045-2322https://doaj.org/article/ad6eee67226e480dbb118d2cbaaa3c6a2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81214-7https://doaj.org/toc/2045-2322Abstract Microfluidic on-chip production of microgels using external gelation can serve numerous applications that involve encapsulation of sensitive cargos. Nevertheless, on-chip production of microgels in microfluidic devices can be challenging due to problems induced by the rapid increase in precursor solution viscosity like clogging. Here, a novel design incorporating a step, which includes a sudden increase in cross-sectional area, before a flow-focusing nozzle was proposed for microfluidic droplet generators. Besides, a shielding oil phase was utilized to avoid the occurrence of emulsification and gelation stages simultaneously. The step which was located before the flow-focusing nozzle facilitated the full shielding of the dispersed phase due to 3-dimensional fluid flow in this geometry. The results showed that the microfluidic device was capable of generating highly monodispersed spherical droplets (CV < 2% for step and CV < 5% for flow-focusing nozzle) with an average diameter in the range of 90–190 μm, both in step and flow-focusing nozzle. Moreover, it was proved that the device could adequately create a shelter for the dispersed phase regardless of the droplet formation locus. The ability of this microfluidic device in the production of microgels was validated by creating alginate microgels (with an average diameter of ~ 100 μm) through an external gelation process with on-chip calcium chloride emulsion in mineral oil.Hamed ShiehMaryam SaadatmandMahnaz EskandariDariush BastaniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hamed Shieh Maryam Saadatmand Mahnaz Eskandari Dariush Bastani Microfluidic on-chip production of microgels using combined geometries
description	Abstract Microfluidic on-chip production of microgels using external gelation can serve numerous applications that involve encapsulation of sensitive cargos. Nevertheless, on-chip production of microgels in microfluidic devices can be challenging due to problems induced by the rapid increase in precursor solution viscosity like clogging. Here, a novel design incorporating a step, which includes a sudden increase in cross-sectional area, before a flow-focusing nozzle was proposed for microfluidic droplet generators. Besides, a shielding oil phase was utilized to avoid the occurrence of emulsification and gelation stages simultaneously. The step which was located before the flow-focusing nozzle facilitated the full shielding of the dispersed phase due to 3-dimensional fluid flow in this geometry. The results showed that the microfluidic device was capable of generating highly monodispersed spherical droplets (CV < 2% for step and CV < 5% for flow-focusing nozzle) with an average diameter in the range of 90–190 μm, both in step and flow-focusing nozzle. Moreover, it was proved that the device could adequately create a shelter for the dispersed phase regardless of the droplet formation locus. The ability of this microfluidic device in the production of microgels was validated by creating alginate microgels (with an average diameter of ~ 100 μm) through an external gelation process with on-chip calcium chloride emulsion in mineral oil.
format	article
author	Hamed Shieh Maryam Saadatmand Mahnaz Eskandari Dariush Bastani
author_facet	Hamed Shieh Maryam Saadatmand Mahnaz Eskandari Dariush Bastani
author_sort	Hamed Shieh
title	Microfluidic on-chip production of microgels using combined geometries
title_short	Microfluidic on-chip production of microgels using combined geometries
title_full	Microfluidic on-chip production of microgels using combined geometries
title_fullStr	Microfluidic on-chip production of microgels using combined geometries
title_full_unstemmed	Microfluidic on-chip production of microgels using combined geometries
title_sort	microfluidic on-chip production of microgels using combined geometries
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ad6eee67226e480dbb118d2cbaaa3c6a
work_keys_str_mv	AT hamedshieh microfluidiconchipproductionofmicrogelsusingcombinedgeometries AT maryamsaadatmand microfluidiconchipproductionofmicrogelsusingcombinedgeometries AT mahnazeskandari microfluidiconchipproductionofmicrogelsusingcombinedgeometries AT dariushbastani microfluidiconchipproductionofmicrogelsusingcombinedgeometries
_version_	1718387347784990720

Microfluidic on-chip production of microgels using combined geometries

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