Crystal structure of the catalytic domain of HIV-1 restriction factor APOBEC3G in complex with ssDNA

APOBEC3G (A3G) is a single-stranded DNA (ssDNA) cytidine deaminase that restricts HIV-1. Here the authors provide molecular insights into A3G substrate recognition by determining the 1.86 Å resolution crystal structure of its catalytic domain bound to ssDNA.

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Autores principales:	Atanu Maiti, Wazo Myint, Tapan Kanai, Krista Delviks-Frankenberry, Christina Sierra Rodriguez, Vinay K. Pathak, Celia A. Schiffer, Hiroshi Matsuo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ad6fc6963a274de1870dee1e6dd27792
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spelling	oai:doaj.org-article:ad6fc6963a274de1870dee1e6dd277922021-12-02T15:34:27ZCrystal structure of the catalytic domain of HIV-1 restriction factor APOBEC3G in complex with ssDNA10.1038/s41467-018-04872-82041-1723https://doaj.org/article/ad6fc6963a274de1870dee1e6dd277922018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04872-8https://doaj.org/toc/2041-1723APOBEC3G (A3G) is a single-stranded DNA (ssDNA) cytidine deaminase that restricts HIV-1. Here the authors provide molecular insights into A3G substrate recognition by determining the 1.86 Å resolution crystal structure of its catalytic domain bound to ssDNA.Atanu MaitiWazo MyintTapan KanaiKrista Delviks-FrankenberryChristina Sierra RodriguezVinay K. PathakCelia A. SchifferHiroshi MatsuoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Atanu Maiti Wazo Myint Tapan Kanai Krista Delviks-Frankenberry Christina Sierra Rodriguez Vinay K. Pathak Celia A. Schiffer Hiroshi Matsuo Crystal structure of the catalytic domain of HIV-1 restriction factor APOBEC3G in complex with ssDNA
description	APOBEC3G (A3G) is a single-stranded DNA (ssDNA) cytidine deaminase that restricts HIV-1. Here the authors provide molecular insights into A3G substrate recognition by determining the 1.86 Å resolution crystal structure of its catalytic domain bound to ssDNA.
format	article
author	Atanu Maiti Wazo Myint Tapan Kanai Krista Delviks-Frankenberry Christina Sierra Rodriguez Vinay K. Pathak Celia A. Schiffer Hiroshi Matsuo
author_facet	Atanu Maiti Wazo Myint Tapan Kanai Krista Delviks-Frankenberry Christina Sierra Rodriguez Vinay K. Pathak Celia A. Schiffer Hiroshi Matsuo
author_sort	Atanu Maiti
title	Crystal structure of the catalytic domain of HIV-1 restriction factor APOBEC3G in complex with ssDNA
title_short	Crystal structure of the catalytic domain of HIV-1 restriction factor APOBEC3G in complex with ssDNA
title_full	Crystal structure of the catalytic domain of HIV-1 restriction factor APOBEC3G in complex with ssDNA
title_fullStr	Crystal structure of the catalytic domain of HIV-1 restriction factor APOBEC3G in complex with ssDNA
title_full_unstemmed	Crystal structure of the catalytic domain of HIV-1 restriction factor APOBEC3G in complex with ssDNA
title_sort	crystal structure of the catalytic domain of hiv-1 restriction factor apobec3g in complex with ssdna
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ad6fc6963a274de1870dee1e6dd27792
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Crystal structure of the catalytic domain of HIV-1 restriction factor APOBEC3G in complex with ssDNA

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