Paradoxical increase in TAG and DAG content parallel the insulin sensitizing effect of unilateral DGAT1 overexpression in rat skeletal muscle.

Paradoxical increase in TAG and DAG content parallel the insulin sensitizing effect of unilateral DGAT1 overexpression in rat skeletal muscle.

<h4>Background</h4>The involvement of muscle triacylglycerol (TAG) storage in the onset of insulin resistance is questioned and the attention has shifted towards inhibition of insulin signalling by the lipid intermediate diacylglycerol (DAG). The enzyme 1,2-acylCoA:diacylglyceroltransfer...

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Autores principales: Silvie Timmers, Johan de Vogel-van den Bosch, Matthijs K C Hesselink, Denis van Beurden, Gert Schaart, Maria Joao Ferraz, Mario Losen, Pilar Martinez-Martinez, Marc H De Baets, Johannes M F G Aerts, Patrick Schrauwen
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/ad75f3a726a74f138354472eda7e5d3b
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