Low vitamin D in narcolepsy with cataplexy.

<h4>Background</h4>Narcolepsy with cataplexy (NC) is currently thought to be an autoimmune-mediated disorder in which environmental risk factors make a significant contribution to its development. It was proposed that vitamin D deficiency plays a role in autoimmune diseases. Here we inve...

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Autores principales:	Bertrand Carlander, Anne Marie Puech-Cathala, Isabelle Jaussent, Sabine Scholz, Sophie Bayard, Valérie Cochen, Yves Dauvilliers
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ad78bb2f0f5a4105ac0c6bb931b30655
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spelling	oai:doaj.org-article:ad78bb2f0f5a4105ac0c6bb931b306552021-11-18T06:53:17ZLow vitamin D in narcolepsy with cataplexy.1932-620310.1371/journal.pone.0020433https://doaj.org/article/ad78bb2f0f5a4105ac0c6bb931b306552011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21633708/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Narcolepsy with cataplexy (NC) is currently thought to be an autoimmune-mediated disorder in which environmental risk factors make a significant contribution to its development. It was proposed that vitamin D deficiency plays a role in autoimmune diseases. Here we investigated whether NC can be associated with 25-hydroxyvitamin D (25(OH)D) level deficiency in patients with NC compared with gender- and age-matched normal controls.<h4>Methodology</h4>Serum level of 25 (OH)D was determined in 51 European patients with typical NC compared to 55 age-, gender-, and ethnicity-matched healthy controls. Demographic and clinical data (age at onset, duration and severity of disease at baseline, and treatment intake at time of study) and season of blood sampling were collected to control for confounding variables.<h4>Principal findings</h4>Serum 25(OH)D concentration was lower in NC compared to controls (median, 59.45 nmol/l [extreme values 24.05-124.03] vs. 74.73 nmol/l [26.88-167.48] p = 0.0039). Patients with NC had significantly greater vitamin D deficiency (<75 nmol/l) than controls (72.5% vs 50.9%, p = 0.0238). Division into quartiles of the whole sample revealed that the risk of being affected with NC increased with lower 25(OH)D level, with a 5.34 OR [1.65-17.27] for the lowest quartile (p = 0.0051). Further adjustment for BMI did not modify the strength of the association (OR: 3.63, 95% CI = 1.06-12.46, p = 0.0191). No between BMI and 25(OH)D interaction, and no correlation between 25(OH)D level and disease duration or severity or treatment intake were found in NC.<h4>Conclusion</h4>We found a higher frequency of vitamin D deficiency in NC. Further studies are needed to assess the contribution of hypovitaminosis D to the risk of developing narcolepsy, and to focus on the utility of assessing vitamin D status to correct potential deficiency.Bertrand CarlanderAnne Marie Puech-CathalaIsabelle JaussentSabine ScholzSophie BayardValérie CochenYves DauvilliersPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 5, p e20433 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bertrand Carlander Anne Marie Puech-Cathala Isabelle Jaussent Sabine Scholz Sophie Bayard Valérie Cochen Yves Dauvilliers Low vitamin D in narcolepsy with cataplexy.
description	<h4>Background</h4>Narcolepsy with cataplexy (NC) is currently thought to be an autoimmune-mediated disorder in which environmental risk factors make a significant contribution to its development. It was proposed that vitamin D deficiency plays a role in autoimmune diseases. Here we investigated whether NC can be associated with 25-hydroxyvitamin D (25(OH)D) level deficiency in patients with NC compared with gender- and age-matched normal controls.<h4>Methodology</h4>Serum level of 25 (OH)D was determined in 51 European patients with typical NC compared to 55 age-, gender-, and ethnicity-matched healthy controls. Demographic and clinical data (age at onset, duration and severity of disease at baseline, and treatment intake at time of study) and season of blood sampling were collected to control for confounding variables.<h4>Principal findings</h4>Serum 25(OH)D concentration was lower in NC compared to controls (median, 59.45 nmol/l [extreme values 24.05-124.03] vs. 74.73 nmol/l [26.88-167.48] p = 0.0039). Patients with NC had significantly greater vitamin D deficiency (<75 nmol/l) than controls (72.5% vs 50.9%, p = 0.0238). Division into quartiles of the whole sample revealed that the risk of being affected with NC increased with lower 25(OH)D level, with a 5.34 OR [1.65-17.27] for the lowest quartile (p = 0.0051). Further adjustment for BMI did not modify the strength of the association (OR: 3.63, 95% CI = 1.06-12.46, p = 0.0191). No between BMI and 25(OH)D interaction, and no correlation between 25(OH)D level and disease duration or severity or treatment intake were found in NC.<h4>Conclusion</h4>We found a higher frequency of vitamin D deficiency in NC. Further studies are needed to assess the contribution of hypovitaminosis D to the risk of developing narcolepsy, and to focus on the utility of assessing vitamin D status to correct potential deficiency.
format	article
author	Bertrand Carlander Anne Marie Puech-Cathala Isabelle Jaussent Sabine Scholz Sophie Bayard Valérie Cochen Yves Dauvilliers
author_facet	Bertrand Carlander Anne Marie Puech-Cathala Isabelle Jaussent Sabine Scholz Sophie Bayard Valérie Cochen Yves Dauvilliers
author_sort	Bertrand Carlander
title	Low vitamin D in narcolepsy with cataplexy.
title_short	Low vitamin D in narcolepsy with cataplexy.
title_full	Low vitamin D in narcolepsy with cataplexy.
title_fullStr	Low vitamin D in narcolepsy with cataplexy.
title_full_unstemmed	Low vitamin D in narcolepsy with cataplexy.
title_sort	low vitamin d in narcolepsy with cataplexy.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/ad78bb2f0f5a4105ac0c6bb931b30655
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Low vitamin D in narcolepsy with cataplexy.

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