Evaluation of myocardial injury patterns and ST changes among critical and non-critical patients with coronavirus-19 disease

Abstract Novel coronavirus disease (COVID-19) has led to a major public health crisis globally. Currently, myocardial damage is speculated to be associated with COVID-19, which can be seen as one of the main causes of death of patients with COVID-19. We therefore, aim to investigate the effects of C...

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Autores principales:	Anam Liaqat, Rao Saad Ali-Khan, Muhammad Asad, Zakia Rafique
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ad7c10e0a94e416d96aabda9ff386f67
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spelling	oai:doaj.org-article:ad7c10e0a94e416d96aabda9ff386f672021-12-02T11:37:23ZEvaluation of myocardial injury patterns and ST changes among critical and non-critical patients with coronavirus-19 disease10.1038/s41598-021-84467-42045-2322https://doaj.org/article/ad7c10e0a94e416d96aabda9ff386f672021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84467-4https://doaj.org/toc/2045-2322Abstract Novel coronavirus disease (COVID-19) has led to a major public health crisis globally. Currently, myocardial damage is speculated to be associated with COVID-19, which can be seen as one of the main causes of death of patients with COVID-19. We therefore, aim to investigate the effects of COVID-19 disease on myocardial injury in hospitalized patients who have been tested positive for COVID-19 pneumonia in this study. A prospective study was conducted among 201 patients with COVID-19 in the Pakistan Military Hospital from April 1 to August 31, 2020, including non-critical cases and critical cases. COVID-19 patients were stratified as critical and non-critical according to the signs and symptoms severity; with those requiring intensive care and invasive mechanical ventilation as critical, and those did not requiring invasive mechanical ventilation as non-critical. A total of 201 COVID-19 patients with critical and non-critical categories presented with myocardial injury. All patients with myocardial injury had an elevation in CKMB and Troponin-I levels. Of these patients, 43.7% presented with new electrocardiography (ECG) changes, and ST depression was typically observed in 36.3% patients. In addition, 18.7% patients presented with abnormal echocardiography findings, with right ventricular dilatation and dysfunction commonly seen among critical group patients. Results analyzed by a logistic regression model showing COVID-19 direct contribution to myocardial injury in these patients. COVID-19 disease directly leads to cardiovascular damage among critical and non-critical patients. Myocardial injury is associated not only with abnormal ECG changes but also with myocardial dysfunction on echocardiography and more commonly observed among critical patients.Anam LiaqatRao Saad Ali-KhanMuhammad AsadZakia RafiqueNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anam Liaqat Rao Saad Ali-Khan Muhammad Asad Zakia Rafique Evaluation of myocardial injury patterns and ST changes among critical and non-critical patients with coronavirus-19 disease
description	Abstract Novel coronavirus disease (COVID-19) has led to a major public health crisis globally. Currently, myocardial damage is speculated to be associated with COVID-19, which can be seen as one of the main causes of death of patients with COVID-19. We therefore, aim to investigate the effects of COVID-19 disease on myocardial injury in hospitalized patients who have been tested positive for COVID-19 pneumonia in this study. A prospective study was conducted among 201 patients with COVID-19 in the Pakistan Military Hospital from April 1 to August 31, 2020, including non-critical cases and critical cases. COVID-19 patients were stratified as critical and non-critical according to the signs and symptoms severity; with those requiring intensive care and invasive mechanical ventilation as critical, and those did not requiring invasive mechanical ventilation as non-critical. A total of 201 COVID-19 patients with critical and non-critical categories presented with myocardial injury. All patients with myocardial injury had an elevation in CKMB and Troponin-I levels. Of these patients, 43.7% presented with new electrocardiography (ECG) changes, and ST depression was typically observed in 36.3% patients. In addition, 18.7% patients presented with abnormal echocardiography findings, with right ventricular dilatation and dysfunction commonly seen among critical group patients. Results analyzed by a logistic regression model showing COVID-19 direct contribution to myocardial injury in these patients. COVID-19 disease directly leads to cardiovascular damage among critical and non-critical patients. Myocardial injury is associated not only with abnormal ECG changes but also with myocardial dysfunction on echocardiography and more commonly observed among critical patients.
format	article
author	Anam Liaqat Rao Saad Ali-Khan Muhammad Asad Zakia Rafique
author_facet	Anam Liaqat Rao Saad Ali-Khan Muhammad Asad Zakia Rafique
author_sort	Anam Liaqat
title	Evaluation of myocardial injury patterns and ST changes among critical and non-critical patients with coronavirus-19 disease
title_short	Evaluation of myocardial injury patterns and ST changes among critical and non-critical patients with coronavirus-19 disease
title_full	Evaluation of myocardial injury patterns and ST changes among critical and non-critical patients with coronavirus-19 disease
title_fullStr	Evaluation of myocardial injury patterns and ST changes among critical and non-critical patients with coronavirus-19 disease
title_full_unstemmed	Evaluation of myocardial injury patterns and ST changes among critical and non-critical patients with coronavirus-19 disease
title_sort	evaluation of myocardial injury patterns and st changes among critical and non-critical patients with coronavirus-19 disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ad7c10e0a94e416d96aabda9ff386f67
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Evaluation of myocardial injury patterns and ST changes among critical and non-critical patients with coronavirus-19 disease

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