New nonlinear multivariable model shows the relationship between central corneal thickness and HRTII topographic parameters in glaucoma patients

Dimitrios Kourkoutas1,2, Gerasimos Georgopoulos1, Antonios Maragos1, et al1Department of Ophthalmology, Medical School, Athens University, Athens, Greece; 2Department of Ophthalmology, 417 Hellenic Army Shared Fund Hospital, Athens, GreecePurpose: In this paper a new nonlinear multivariable regressi...

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Autores principales:	Dimitrios Kourkoutas, Gerasimos Georgopoulos, Antonios Maragos, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2009
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/ad7d05ae2aa741789961ca3cd415256c
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spelling	oai:doaj.org-article:ad7d05ae2aa741789961ca3cd415256c2021-12-02T00:35:42ZNew nonlinear multivariable model shows the relationship between central corneal thickness and HRTII topographic parameters in glaucoma patients1177-54671177-5483https://doaj.org/article/ad7d05ae2aa741789961ca3cd415256c2009-04-01T00:00:00Zhttp://www.dovepress.com/new-nonlinear-multivariable-model-shows-the-relationship-between-centr-a3025https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Dimitrios Kourkoutas1,2, Gerasimos Georgopoulos1, Antonios Maragos1, et al1Department of Ophthalmology, Medical School, Athens University, Athens, Greece; 2Department of Ophthalmology, 417 Hellenic Army Shared Fund Hospital, Athens, GreecePurpose: In this paper a new nonlinear multivariable regression method is presented in order to investigate the relationship between the central corneal thickness (CCT) and the Heidelberg Retina Tomograph (HRTII) optic nerve head (ONH) topographic measurements, in patients with established glaucoma.Methods: Forty nine eyes of 49 patients with glaucoma were included in this study. Inclusion criteria were patients with (a) HRT II ONH imaging of good quality (SD 30&nbsp;&lt; &mu;m), (b) reliable Humphrey visual field tests (30-2 program), and (c) bilateral CCT measurements with ultrasonic contact pachymetry. Patients were classified as glaucomatous based on visual field and/or ONH damage. The relationship between CCT and topographic parameters was analyzed by using the new nonlinear multivariable regression model.Results: In the entire group, CCT was 549.78 &plusmn; 33.08 &mu;m (range: 484&ndash;636 &mu;m); intraocular pressure (IOP) was 16.4 &plusmn; 2.67 mmHg (range: 11&ndash;23 mmHg); MD was &minus;3.80 &plusmn; 4.97 dB (range: 4.04 &ndash; [&minus;20.4] dB); refraction was &minus;0.78 &plusmn; 2.46 D (range: &minus;6.0 D to +3.0 D). The new nonlinear multivariable regression model we used indicated that CCT was significantly related (R2 = 0.227, p&nbsp;&lt; 0.01) with rim volume nasally and type of diagnosis.Conclusions: By using the new nonlinear multivariable regression model, in patients with established glaucoma, our data showed that there is a statistically significant correlation between CCT and HRTII ONH structural measurements, in glaucoma patients.Keywords: central corneal thickness, glaucoma, optic nerve head, HRT&nbsp; Dimitrios KourkoutasGerasimos GeorgopoulosAntonios Maragoset alDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2009, Iss default, Pp 313-323 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Dimitrios Kourkoutas Gerasimos Georgopoulos Antonios Maragos et al New nonlinear multivariable model shows the relationship between central corneal thickness and HRTII topographic parameters in glaucoma patients
description	Dimitrios Kourkoutas1,2, Gerasimos Georgopoulos1, Antonios Maragos1, et al1Department of Ophthalmology, Medical School, Athens University, Athens, Greece; 2Department of Ophthalmology, 417 Hellenic Army Shared Fund Hospital, Athens, GreecePurpose: In this paper a new nonlinear multivariable regression method is presented in order to investigate the relationship between the central corneal thickness (CCT) and the Heidelberg Retina Tomograph (HRTII) optic nerve head (ONH) topographic measurements, in patients with established glaucoma.Methods: Forty nine eyes of 49 patients with glaucoma were included in this study. Inclusion criteria were patients with (a) HRT II ONH imaging of good quality (SD 30&nbsp;&lt; &mu;m), (b) reliable Humphrey visual field tests (30-2 program), and (c) bilateral CCT measurements with ultrasonic contact pachymetry. Patients were classified as glaucomatous based on visual field and/or ONH damage. The relationship between CCT and topographic parameters was analyzed by using the new nonlinear multivariable regression model.Results: In the entire group, CCT was 549.78 &plusmn; 33.08 &mu;m (range: 484&ndash;636 &mu;m); intraocular pressure (IOP) was 16.4 &plusmn; 2.67 mmHg (range: 11&ndash;23 mmHg); MD was &minus;3.80 &plusmn; 4.97 dB (range: 4.04 &ndash; [&minus;20.4] dB); refraction was &minus;0.78 &plusmn; 2.46 D (range: &minus;6.0 D to +3.0 D). The new nonlinear multivariable regression model we used indicated that CCT was significantly related (R2 = 0.227, p&nbsp;&lt; 0.01) with rim volume nasally and type of diagnosis.Conclusions: By using the new nonlinear multivariable regression model, in patients with established glaucoma, our data showed that there is a statistically significant correlation between CCT and HRTII ONH structural measurements, in glaucoma patients.Keywords: central corneal thickness, glaucoma, optic nerve head, HRT&nbsp;
format	article
author	Dimitrios Kourkoutas Gerasimos Georgopoulos Antonios Maragos et al
author_facet	Dimitrios Kourkoutas Gerasimos Georgopoulos Antonios Maragos et al
author_sort	Dimitrios Kourkoutas
title	New nonlinear multivariable model shows the relationship between central corneal thickness and HRTII topographic parameters in glaucoma patients
title_short	New nonlinear multivariable model shows the relationship between central corneal thickness and HRTII topographic parameters in glaucoma patients
title_full	New nonlinear multivariable model shows the relationship between central corneal thickness and HRTII topographic parameters in glaucoma patients
title_fullStr	New nonlinear multivariable model shows the relationship between central corneal thickness and HRTII topographic parameters in glaucoma patients
title_full_unstemmed	New nonlinear multivariable model shows the relationship between central corneal thickness and HRTII topographic parameters in glaucoma patients
title_sort	new nonlinear multivariable model shows the relationship between central corneal thickness and hrtii topographic parameters in glaucoma patients
publisher	Dove Medical Press
publishDate	2009
url	https://doaj.org/article/ad7d05ae2aa741789961ca3cd415256c
work_keys_str_mv	AT dimitrioskourkoutas newnonlinearmultivariablemodelshowstherelationshipbetweencentralcornealthicknessandhrtiitopographicparametersinglaucomapatients AT gerasimosgeorgopoulos newnonlinearmultivariablemodelshowstherelationshipbetweencentralcornealthicknessandhrtiitopographicparametersinglaucomapatients AT antoniosmaragos newnonlinearmultivariablemodelshowstherelationshipbetweencentralcornealthicknessandhrtiitopographicparametersinglaucomapatients AT etal newnonlinearmultivariablemodelshowstherelationshipbetweencentralcornealthicknessandhrtiitopographicparametersinglaucomapatients
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New nonlinear multivariable model shows the relationship between central corneal thickness and HRTII topographic parameters in glaucoma patients

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