On wakefulness fluctuations as a source of BOLD functional connectivity dynamics

Abstract Human brain dynamics and functional connectivity fluctuate over a range of temporal scales in coordination with internal states and environmental demands. However, the neurobiological significance and consequences of functional connectivity dynamics during rest have not yet been established...

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Autores principales:	Ariel Haimovici, Enzo Tagliazucchi, Pablo Balenzuela, Helmut Laufs
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ad7d17f2df9d4026a6c59a37e03227eb
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spelling	oai:doaj.org-article:ad7d17f2df9d4026a6c59a37e03227eb2021-12-02T12:31:47ZOn wakefulness fluctuations as a source of BOLD functional connectivity dynamics10.1038/s41598-017-06389-42045-2322https://doaj.org/article/ad7d17f2df9d4026a6c59a37e03227eb2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06389-4https://doaj.org/toc/2045-2322Abstract Human brain dynamics and functional connectivity fluctuate over a range of temporal scales in coordination with internal states and environmental demands. However, the neurobiological significance and consequences of functional connectivity dynamics during rest have not yet been established. We show that the coarse-grained clustering of whole-brain dynamic connectivity measured with magnetic resonance imaging reveals discrete patterns (dynamic connectivity states) associated with wakefulness and sleep. We validate this using EEG in healthy subjects and patients with narcolepsy and by matching our results with previous findings in a large collaborative database. We also show that drowsiness may account for previous reports of metastable connectivity states associated with different levels of functional integration. This implies that future studies of transient functional connectivity must independently monitor wakefulness. We conclude that a possible neurobiological significance of dynamic connectivity states, computed at a sufficiently coarse temporal scale, is that of fluctuations in wakefulness.Ariel HaimoviciEnzo TagliazucchiPablo BalenzuelaHelmut LaufsNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ariel Haimovici Enzo Tagliazucchi Pablo Balenzuela Helmut Laufs On wakefulness fluctuations as a source of BOLD functional connectivity dynamics
description	Abstract Human brain dynamics and functional connectivity fluctuate over a range of temporal scales in coordination with internal states and environmental demands. However, the neurobiological significance and consequences of functional connectivity dynamics during rest have not yet been established. We show that the coarse-grained clustering of whole-brain dynamic connectivity measured with magnetic resonance imaging reveals discrete patterns (dynamic connectivity states) associated with wakefulness and sleep. We validate this using EEG in healthy subjects and patients with narcolepsy and by matching our results with previous findings in a large collaborative database. We also show that drowsiness may account for previous reports of metastable connectivity states associated with different levels of functional integration. This implies that future studies of transient functional connectivity must independently monitor wakefulness. We conclude that a possible neurobiological significance of dynamic connectivity states, computed at a sufficiently coarse temporal scale, is that of fluctuations in wakefulness.
format	article
author	Ariel Haimovici Enzo Tagliazucchi Pablo Balenzuela Helmut Laufs
author_facet	Ariel Haimovici Enzo Tagliazucchi Pablo Balenzuela Helmut Laufs
author_sort	Ariel Haimovici
title	On wakefulness fluctuations as a source of BOLD functional connectivity dynamics
title_short	On wakefulness fluctuations as a source of BOLD functional connectivity dynamics
title_full	On wakefulness fluctuations as a source of BOLD functional connectivity dynamics
title_fullStr	On wakefulness fluctuations as a source of BOLD functional connectivity dynamics
title_full_unstemmed	On wakefulness fluctuations as a source of BOLD functional connectivity dynamics
title_sort	on wakefulness fluctuations as a source of bold functional connectivity dynamics
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ad7d17f2df9d4026a6c59a37e03227eb
work_keys_str_mv	AT arielhaimovici onwakefulnessfluctuationsasasourceofboldfunctionalconnectivitydynamics AT enzotagliazucchi onwakefulnessfluctuationsasasourceofboldfunctionalconnectivitydynamics AT pablobalenzuela onwakefulnessfluctuationsasasourceofboldfunctionalconnectivitydynamics AT helmutlaufs onwakefulnessfluctuationsasasourceofboldfunctionalconnectivitydynamics
_version_	1718394298839334912

On wakefulness fluctuations as a source of BOLD functional connectivity dynamics

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