Evaluation of organ glucose metabolism by 18F-FDG accumulation with insulin loading in aged mice compared with young normal mice

Abstract It is important to determine the functional changes of organs that occur as a result of aging, the understanding of which may lead to the maintenance of a healthy life. Glucose metabolism in healthy bodies is one of the potential markers used to evaluate the changes of organ function. Thus,...

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Autores principales:	Jingmin Zhao, Chengbo Tan, Ryota Imai, Naoyuki Ukon, Saki Shimoyama, Yuko Maejima, Yuji Omiya, Kazuhiro Takahashi, Hiroshi Ito, Guangxian Nan, Songji Zhao, Kenju Shimomura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ad808f0989604a349872e588c551ada8
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spelling	oai:doaj.org-article:ad808f0989604a349872e588c551ada82021-12-02T18:17:41ZEvaluation of organ glucose metabolism by 18F-FDG accumulation with insulin loading in aged mice compared with young normal mice10.1038/s41598-021-86825-82045-2322https://doaj.org/article/ad808f0989604a349872e588c551ada82021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86825-8https://doaj.org/toc/2045-2322Abstract It is important to determine the functional changes of organs that occur as a result of aging, the understanding of which may lead to the maintenance of a healthy life. Glucose metabolism in healthy bodies is one of the potential markers used to evaluate the changes of organ function. Thus, information about normal organ glucose metabolism may help to understand the functional changes of organs. [18F]-Fluoro-2-deoxy-2-d-glucose (18F-FDG), a glucose analog, has been used to measure glucose metabolism in various fields, such as basic medical research and drug discovery. However, glucose metabolism changes in aged animals have not yet been fully clarified. The aim of this study is to evaluate changes in glucose metabolism in organs and brain regions by measuring 18F-FDG accumulation and 18F-FDG autoradiography with insulin loading in aged and young wild-type mice. In the untreated groups, the levels of 18F-FDG accumulation in the blood, plasma, muscle, lungs, spleen, pancreas, testes, stomach, small intestine, kidneys, liver, brain, and brain regions, namely, the cortex, striatum, thalamus, and hippocampus, were all significantly higher in the aged mice. The treated group showed lower 18F-FDG accumulation levels in the pancreas and kidneys, as well as in the cortex, striatum, thalamus, and hippocampus in the aged mice than the untreated groups, whereas higher 18F-FDG accumulation levels were observed in those in the young mice. These results demonstrate that insulin loading decreases effect on 18F-FDG accumulation levels in some organs of the aged mice. Therefore, aging can increase insulin resistance and lead to systemic glucose metabolism dysfunction.Jingmin ZhaoChengbo TanRyota ImaiNaoyuki UkonSaki ShimoyamaYuko MaejimaYuji OmiyaKazuhiro TakahashiHiroshi ItoGuangxian NanSongji ZhaoKenju ShimomuraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jingmin Zhao Chengbo Tan Ryota Imai Naoyuki Ukon Saki Shimoyama Yuko Maejima Yuji Omiya Kazuhiro Takahashi Hiroshi Ito Guangxian Nan Songji Zhao Kenju Shimomura Evaluation of organ glucose metabolism by 18F-FDG accumulation with insulin loading in aged mice compared with young normal mice
description	Abstract It is important to determine the functional changes of organs that occur as a result of aging, the understanding of which may lead to the maintenance of a healthy life. Glucose metabolism in healthy bodies is one of the potential markers used to evaluate the changes of organ function. Thus, information about normal organ glucose metabolism may help to understand the functional changes of organs. [18F]-Fluoro-2-deoxy-2-d-glucose (18F-FDG), a glucose analog, has been used to measure glucose metabolism in various fields, such as basic medical research and drug discovery. However, glucose metabolism changes in aged animals have not yet been fully clarified. The aim of this study is to evaluate changes in glucose metabolism in organs and brain regions by measuring 18F-FDG accumulation and 18F-FDG autoradiography with insulin loading in aged and young wild-type mice. In the untreated groups, the levels of 18F-FDG accumulation in the blood, plasma, muscle, lungs, spleen, pancreas, testes, stomach, small intestine, kidneys, liver, brain, and brain regions, namely, the cortex, striatum, thalamus, and hippocampus, were all significantly higher in the aged mice. The treated group showed lower 18F-FDG accumulation levels in the pancreas and kidneys, as well as in the cortex, striatum, thalamus, and hippocampus in the aged mice than the untreated groups, whereas higher 18F-FDG accumulation levels were observed in those in the young mice. These results demonstrate that insulin loading decreases effect on 18F-FDG accumulation levels in some organs of the aged mice. Therefore, aging can increase insulin resistance and lead to systemic glucose metabolism dysfunction.
format	article
author	Jingmin Zhao Chengbo Tan Ryota Imai Naoyuki Ukon Saki Shimoyama Yuko Maejima Yuji Omiya Kazuhiro Takahashi Hiroshi Ito Guangxian Nan Songji Zhao Kenju Shimomura
author_facet	Jingmin Zhao Chengbo Tan Ryota Imai Naoyuki Ukon Saki Shimoyama Yuko Maejima Yuji Omiya Kazuhiro Takahashi Hiroshi Ito Guangxian Nan Songji Zhao Kenju Shimomura
author_sort	Jingmin Zhao
title	Evaluation of organ glucose metabolism by 18F-FDG accumulation with insulin loading in aged mice compared with young normal mice
title_short	Evaluation of organ glucose metabolism by 18F-FDG accumulation with insulin loading in aged mice compared with young normal mice
title_full	Evaluation of organ glucose metabolism by 18F-FDG accumulation with insulin loading in aged mice compared with young normal mice
title_fullStr	Evaluation of organ glucose metabolism by 18F-FDG accumulation with insulin loading in aged mice compared with young normal mice
title_full_unstemmed	Evaluation of organ glucose metabolism by 18F-FDG accumulation with insulin loading in aged mice compared with young normal mice
title_sort	evaluation of organ glucose metabolism by 18f-fdg accumulation with insulin loading in aged mice compared with young normal mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ad808f0989604a349872e588c551ada8
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Evaluation of organ glucose metabolism by 18F-FDG accumulation with insulin loading in aged mice compared with young normal mice

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